The Lateral Hypothalamic and BNST GABAergic Projections to the Anterior Ventrolateral Periaqueductal Gray Regulate Feeding.
Animals
Antipsychotic Agents
/ pharmacology
Body Weight
/ drug effects
Central Amygdaloid Nucleus
/ drug effects
Clozapine
/ analogs & derivatives
Feeding Behavior
/ physiology
GABA-A Receptor Agonists
/ pharmacology
GABAergic Neurons
/ cytology
Hypothalamic Area, Lateral
/ cytology
Mice
Muscimol
/ pharmacology
Neural Pathways
/ physiology
Optogenetics
Periaqueductal Gray
/ cytology
Septal Nuclei
/ cytology
GABAergic pathway
feeding
lateral hypothalamus
mice
vlPAG
Journal
Cell reports
ISSN: 2211-1247
Titre abrégé: Cell Rep
Pays: United States
ID NLM: 101573691
Informations de publication
Date de publication:
16 07 2019
16 07 2019
Historique:
received:
14
08
2017
revised:
18
03
2019
accepted:
14
06
2019
entrez:
18
7
2019
pubmed:
18
7
2019
medline:
28
8
2020
Statut:
ppublish
Résumé
Overeating is a serious issue in modern society, causing many health problems, including obesity. Although the hypothalamus has been previously identified as the key brain structure that regulates body weight homeostasis, the downstream pathways and non-canonical neural circuitry involved in feeding behavior remain largely uncharacterized. Here, we discover that suppressing the activity of GABAergic cells in the anterior ventrolateral periaqueductal gray (vlPAG), whether directly or through long-projection GABAergic inputs from either the bed nucleus of the stria terminalis (BNST) or the lateral hypothalamus (LH), is sufficient to promptly induce feeding behavior in well-fed mice. In contrast, optogenetic activation of these cells interrupts food intake in starved mice. Long-term chemogenetic manipulation of vlPAG GABAergic cell activity elicits a corresponding change in mouse body weight. Our studies reveal distinct midbrain GABAergic pathways and highlight an important role of GABAergic cells in the anterior vlPAG in feeding behavior.
Identifiants
pubmed: 31315042
pii: S2211-1247(19)30824-1
doi: 10.1016/j.celrep.2019.06.051
pii:
doi:
Substances chimiques
Antipsychotic Agents
0
GABA-A Receptor Agonists
0
Muscimol
2763-96-4
Clozapine
J60AR2IKIC
clozapine N-oxide
MZA8BK588J
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
616-624.e5Informations de copyright
Copyright © 2019 The Author(s). Published by Elsevier Inc. All rights reserved.