Sulfonic nucleic acids (SNAs): a new class of substrate mimics for ribonuclease A inhibition.

Enzyme Inhibitors / chemical synthesis Molecular Docking Simulation Nucleic Acid Conformation Nucleic Acids / chemical synthesis Ribonuclease, Pancreatic / antagonists & inhibitors Sulfonic Acids / chemical synthesis

Journal

Organic & biomolecular chemistry
ISSN: 1477-0539
Titre abrégé: Org Biomol Chem
Pays: England
ID NLM: 101154995

Informations de publication

Date de publication:
14 08 2019
Historique:
pubmed: 20 7 2019
medline: 23 1 2020
entrez: 20 7 2019
Statut: ppublish

Résumé

Sulfonic nucleic acids were identified as inhibitors of ribonuclease A (RNase A). The incorporation of a strongly acidic group (sulfonic, -SO

Identifiants

DOI: 10.1039/c9ob01250h PMID: 31322157
pubmed: 31322157
doi: 10.1039/c9ob01250h
doi:

Substances chimiques

Enzyme Inhibitors 0
Nucleic Acids 0
Sulfonic Acids 0
Ribonuclease, Pancreatic EC 3.1.27.5

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

7215-7221

Auteurs

Dhrubajyoti Datta (D)

Department of Chemistry, Indian Institute of Technology Kharagpur, Kharagpur 721302, India. swagata@chem.iitkgp.ac.in tpathak@chem.iitkgp.ac.in.
ORCID: 0000-0003-2077-1294

Swagata Dasgupta (S)

Department of Chemistry, Indian Institute of Technology Kharagpur, Kharagpur 721302, India. swagata@chem.iitkgp.ac.in tpathak@chem.iitkgp.ac.in.
ORCID: 0000-0003-2074-1247

Tanmaya Pathak (T)

Department of Chemistry, Indian Institute of Technology Kharagpur, Kharagpur 721302, India. swagata@chem.iitkgp.ac.in tpathak@chem.iitkgp.ac.in.
ORCID: 0000-0001-9645-7555

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Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Mécanismes moléculaires de l'action pharmacologique › Antienzymes › Sulfonic nucleic acids (SNAs): a new class of...
questionsmedicales.fr › Sciences de l'information › Méthodologies informatiques › Simulation numérique › Simulation de docking moléculaire › Sulfonic nucleic acids (SNAs): a new class of...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Conformation d'acide nucléique › Sulfonic nucleic acids (SNAs): a new class of...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › Sulfonic nucleic acids (SNAs): a new class of...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Esterases › Ribonucléases › Endoribonucleases › Pancreatic ribonuclease › Sulfonic nucleic acids (SNAs): a new class of...
questionsmedicales.fr › Composés chimiques organiques › Composés du soufre › Acides du soufre › Acides sulfoniques › Sulfonic nucleic acids (SNAs): a new class of...