Short RNA regulators: the past, the present, the future, and implications for precision medicine and health disparities.
Journal
Current opinion in biotechnology
ISSN: 1879-0429
Titre abrégé: Curr Opin Biotechnol
Pays: England
ID NLM: 9100492
Informations de publication
Date de publication:
08 2019
08 2019
Historique:
received:
01
03
2019
revised:
09
05
2019
accepted:
27
05
2019
pubmed:
20
7
2019
medline:
8
2
2020
entrez:
20
7
2019
Statut:
ppublish
Résumé
We herein provide a brief review of the trajectory that the field of short RNA research followed in the last 25 years. We place emphasis on the unexpected discoveries and the ramifications of these discoveries for the field, as well as offer some thoughts about what the next 25 years may bring. Arguably, the uncovered dependence of different types of short RNAs on individual attributes such as a person's sex, population origin, race, and on tissue type, tissue state, and disease was most unexpected. This dependence has important ramifications in that it will provide a boost to our understanding of the molecular mechanisms of health disparities as well as pave the way for novel approaches to designing improved and personalized diagnostics and therapeutics.
Identifiants
pubmed: 31323485
pii: S0958-1669(18)30237-4
doi: 10.1016/j.copbio.2019.05.014
pmc: PMC7181343
mid: NIHMS1558568
pii:
doi:
Substances chimiques
RNA
63231-63-0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
202-210Subventions
Organisme : NIGMS NIH HHS
ID : R01 GM106047
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL141424
Pays : United States
Informations de copyright
Copyright © 2019 The Authors. Published by Elsevier Ltd.. All rights reserved.
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