Deletion of a Csf1r enhancer selectively impacts CSF1R expression and development of tissue macrophage populations.
Animals
Base Sequence
Cell Differentiation
Cell Proliferation
Disease Models, Animal
Embryonic Stem Cells
/ pathology
Epidermal Growth Factor
Female
Gene Expression Regulation
Genes, fms
/ genetics
Macrophage Colony-Stimulating Factor
/ genetics
Macrophages
/ metabolism
Male
Mice
Mice, Inbred C57BL
Mice, Knockout
Microglia
/ metabolism
Monocytes
/ metabolism
Phagocytosis
RAW 264.7 Cells
Receptors, Granulocyte-Macrophage Colony-Stimulating Factor
/ genetics
Regulatory Sequences, Nucleic Acid
/ genetics
Sequence Deletion
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
19 07 2019
19 07 2019
Historique:
received:
29
01
2019
accepted:
15
06
2019
entrez:
21
7
2019
pubmed:
22
7
2019
medline:
18
12
2019
Statut:
epublish
Résumé
The proliferation, differentiation and survival of mononuclear phagocytes depend on signals from the receptor for macrophage colony-stimulating factor, CSF1R. The mammalian Csf1r locus contains a highly conserved super-enhancer, the fms-intronic regulatory element (FIRE). Here we show that genomic deletion of FIRE in mice selectively impacts CSF1R expression and tissue macrophage development in specific tissues. Deletion of FIRE ablates macrophage development from murine embryonic stem cells. Csf1r
Identifiants
pubmed: 31324781
doi: 10.1038/s41467-019-11053-8
pii: 10.1038/s41467-019-11053-8
pmc: PMC6642117
doi:
Substances chimiques
Csf1r protein, mouse
0
Emr4 protein, mouse
0
Receptors, Granulocyte-Macrophage Colony-Stimulating Factor
0
Epidermal Growth Factor
62229-50-9
Macrophage Colony-Stimulating Factor
81627-83-0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
3215Subventions
Organisme : Medical Research Council
ID : MR/M010341/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_PC_16031
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/S000763/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/M020827/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/M019969/1
Pays : United Kingdom
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