Glutaminase activity in GLS1 Het mouse brain compared to putative pharmacological inhibition by ebselen using ex vivo MRS.

Amino Acids / analysis Animals Azoles / pharmacology Brain / enzymology Brain Chemistry / drug effects Female Glutaminase / analysis Heterozygote Hippocampus / drug effects Isoindoles Male Mice Nerve Tissue Proteins / analysis Nuclear Magnetic Resonance, Biomolecular Organoselenium Compounds / pharmacology Sequence Deletion gamma-Aminobutyric Acid / analysis
Focused beam microwave irradiation GABA Glutamate-glutamine cycling Magnetic resonance spectroscopy Schizophrenia pharmacotherapy

Journal

Neurochemistry international
ISSN: 1872-9754
Titre abrégé: Neurochem Int
Pays: England
ID NLM: 8006959

Informations de publication

Date de publication:
10 2019
Historique:
received: 17 05 2019
revised: 28 06 2019
accepted: 18 07 2019
pubmed: 22 7 2019
medline: 12 5 2020
entrez: 22 7 2019
Statut: ppublish

Résumé

Glutaminase mediates the recycling of neurotransmitter glutamate, supporting most excitatory neurotransmission in the mammalian central nervous system. A constitutive heterozygous reduction in GLS1 engenders in mice a model of schizophrenia resilience and associated increases in Gln, reductions in Glu and activity-dependent attenuation of excitatory synaptic transmission. Hippocampal brain slices from GLS1 heterozygous mice metabolize less Gln to Glu. Whether glutaminase activity is diminished in the intact brain in GLS1 heterozygous mice has not been assessed, nor the regional impact. Moreover, it is not known whether pharmacological inhibition would mimic the genetic reduction. We addressed this using magnetic resonance spectroscopy to assess amino acid content and

Identifiants

DOI: 10.1016/j.neuint.2019.104508 PMID: 31326460 PMC: PMC6941670
pubmed: 31326460
pii: S0197-0186(19)30263-3
doi: 10.1016/j.neuint.2019.104508
pmc: PMC6941670
mid: NIHMS1064162
pii:
doi:

Substances chimiques

Amino Acids 0
Azoles 0
Isoindoles 0
Nerve Tissue Proteins 0
Organoselenium Compounds 0
ebselen 40X2P7DPGH
gamma-Aminobutyric Acid 56-12-2
GLS1 protein, mouse EC 3.5.1.2
Glutaminase EC 3.5.1.2

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

104508

Subventions

Organisme : NIMH NIH HHS
ID : R01 MH087758
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH109159
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH117128
Pays : United States

Informations de copyright

Copyright © 2019 Elsevier Ltd. All rights reserved.

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Auteurs

Lauren Kosten (L)

Molecular Imaging Center Antwerp, University of Antwerp, Antwerp, Belgium.

Golam M I Chowdhury (GMI)

Department of Psychiatry, Magnetic Resonance Research Center, Yale University School of Medicine, USA.

Susana Mingote (S)

Department of Psychiatry, Columbia University, USA; Department of Molecular Therapeutics, NYS Psychiatric Institute, USA; Neuroscience, Advanced Science Research Center at the Graduate Center of the City University of New York, USA.

Steven Staelens (S)

Molecular Imaging Center Antwerp, University of Antwerp, Antwerp, Belgium.

Douglas L Rothman (DL)

Department of Radiology & Biomedical Imaging, Magnetic Resonance Research Center, Yale University School of Medicine, USA.

Kevin L Behar (KL)

Department of Psychiatry, Magnetic Resonance Research Center, Yale University School of Medicine, USA. Electronic address: Kevin.behar@yale.edu.

Stephen Rayport (S)

Department of Psychiatry, Columbia University, USA; Department of Molecular Therapeutics, NYS Psychiatric Institute, USA. Electronic address: stephen.rayport@nyspi.columbia.edu.

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Acides aminés › Glutaminase activity in GLS1 Het mouse brain...
questionsmedicales.fr › Eucaryotes › Animaux › Glutaminase activity in GLS1 Het mouse brain...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Azoles › Glutaminase activity in GLS1 Het mouse brain...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Glutaminase activity in GLS1 Het mouse brain...
questionsmedicales.fr › Métabolisme › Chimie du cerveau › Glutaminase activity in GLS1 Het mouse brain...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Amidohydrolases › Glutaminase › Glutaminase activity in GLS1 Het mouse brain...
questionsmedicales.fr › Phénomènes génétiques › Génotype › Hétérozygote › Glutaminase activity in GLS1 Het mouse brain...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Prosencéphale › Télencéphale › Cerveau › Cortex cérébral › Hippocampe › Glutaminase activity in GLS1 Het mouse brain...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Isoindoles › Glutaminase activity in GLS1 Het mouse brain...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Glutaminase activity in GLS1 Het mouse brain...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de tissu nerveux › Glutaminase activity in GLS1 Het mouse brain...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Analyse spectrale › Spectroscopie par résonance magnétique › Résonance magnétique nucléaire biomoléculaire › Glutaminase activity in GLS1 Het mouse brain...
questionsmedicales.fr › Composés chimiques organiques › Composés organiques du sélénium › Glutaminase activity in GLS1 Het mouse brain...
questionsmedicales.fr › Phénomènes génétiques › Mutagenèse › Délétion de séquence › Glutaminase activity in GLS1 Het mouse brain...
questionsmedicales.fr › Acides aminés, peptides et protéines › Acides aminés › Amino-butyrates › Acide gamma-amino-butyrique › Glutaminase activity in GLS1 Het mouse brain...