Stilbenoid-Mediated Epigenetic Activation of Semaphorin 3A in Breast Cancer Cells Involves Changes in Dynamic Interactions of DNA with DNMT3A and NF1C Transcription Factor.
Breast Neoplasms
/ metabolism
Cell Line
Cell Line, Tumor
Cell Proliferation
/ drug effects
DNA
/ metabolism
DNA (Cytosine-5-)-Methyltransferases
/ genetics
DNA Methylation
/ drug effects
DNA Methyltransferase 3A
Epigenesis, Genetic
/ drug effects
Female
Gene Expression
Gene Knockdown Techniques
Gene Silencing
/ drug effects
Homeodomain Proteins
/ genetics
Humans
NFI Transcription Factors
/ metabolism
Neoplasm Invasiveness
/ prevention & control
Promoter Regions, Genetic
/ genetics
Resveratrol
/ pharmacology
Semaphorin-3A
/ genetics
Stilbenes
/ pharmacology
Transcription Factors
/ genetics
DNA methylation
DNMT3A
NF1C
breast cancer
stilbenoids
tumor suppression
Journal
Molecular nutrition & food research
ISSN: 1613-4133
Titre abrégé: Mol Nutr Food Res
Pays: Germany
ID NLM: 101231818
Informations de publication
Date de publication:
10 2019
10 2019
Historique:
received:
18
12
2018
revised:
13
06
2019
pubmed:
22
7
2019
medline:
23
6
2020
entrez:
22
7
2019
Statut:
ppublish
Résumé
Loci-specific increase in DNA methylation occurs in cancer and may underlie gene silencing. It is investigated whether dietary stilbenoids, resveratrol, and pterostilbene exert time-dependent effects on DNA methylation patterns and specifically methylation-silenced tumor suppressor genes in breast cancer cells. Following genome-wide DNA methylation analysis with Illumina-450K, changes characteristic of early and late response to stilbenoids are identified. Interestingly, often the same genes but at different CpG loci, the same gene families, or the same functional gene categories are affected. CpG loci that lose methylation in exposed cells correspond to genes functionally associated with cancer suppression. There is a group of genes, including SEMA3A, at which the magnitude of hypomethylation in response to stilbenoids rises with increasing invasive potential of cancer cells. Decreased DNA methylation at SEMA3A promoter and concomitant gene upregulation coincide with increased occupancy of active histone marks. Open chromatin upon exposure to stilbenoids may be linked to decreased DNMT3A binding followed by increased NF1C transcription factor occupancy. Sequestration of DNMT3A is possibly a result of stilbenoid-mediated increase in SALL3 expression, which was previously shown to bind and inhibit DNMT3A activity. The findings define mechanistic players in stilbenoid-mediated epigenetic reactivation of genes suppressing cancer.
Identifiants
pubmed: 31327173
doi: 10.1002/mnfr.201801386
doi:
Substances chimiques
DNMT3A protein, human
0
Homeodomain Proteins
0
NFI Transcription Factors
0
SALL3 protein, human
0
Semaphorin-3A
0
Stilbenes
0
Transcription Factors
0
transcription factor nuclear factor 1
0
pterostilbene
26R60S6A5I
DNA
9007-49-2
DNA (Cytosine-5-)-Methyltransferases
EC 2.1.1.37
DNA Methyltransferase 3A
EC 2.1.1.37
Resveratrol
Q369O8926L
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e1801386Informations de copyright
© 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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