Heavy drinking in adolescents is associated with change in brainstem microstructure and reward sensitivity.
Adolescent
Alcohol Abstinence
/ psychology
Alcoholism
/ diagnostic imaging
Anisotropy
Brain Stem
/ diagnostic imaging
Diffusion Tensor Imaging
Female
Humans
Male
Motivation
Nucleus Accumbens
/ diagnostic imaging
Pons
/ diagnostic imaging
Reward
Underage Drinking
/ psychology
Ventral Tegmental Area
/ diagnostic imaging
White Matter
/ diagnostic imaging
adolescent
alcohol use disorder
brainstem
diffusion MRI
Journal
Addiction biology
ISSN: 1369-1600
Titre abrégé: Addict Biol
Pays: United States
ID NLM: 9604935
Informations de publication
Date de publication:
05 2020
05 2020
Historique:
received:
03
10
2018
revised:
31
03
2019
accepted:
02
05
2019
pubmed:
23
7
2019
medline:
25
6
2021
entrez:
23
7
2019
Statut:
ppublish
Résumé
Heavy drinker adolescents: altered brainstem microstructure. The cortical-cerebellar circuit is vulnerable to heavy drinking (HD) in adults. We hypothesized early microstructural modifications of the pons/midbrain region, containing core structures of the reward system, in HD adolescents. Thirty-two otherwise symptom-free HDs at age 14 (HD14) and 24 abstainers becoming HDs at age 16 (HD16) were identified in the community with the Alcohol Use Disorders Identification Test (AUDIT) and compared with abstainers. The monetary incentive delay (MID) task assessed reward-sensitive performance. Voxelwise statistics of diffusion tensor imaging (DTI) values in the thalamo-ponto-mesencephalic region were obtained using tract-based spatial statistics. Projections between the ventral tegmental area (VTA) and the nucleus accumbens (NAcc) were identified by probabilistic tractography. Lower fraction of anisotropy and higher radial diffusivity (RD) values were detected in the upper dorsal pons of HD14 adolescents, and a trend for higher RD in HD16, compared with abstainers. When expecting reward, HD14 had higher MID task success scores than abstainers, and success scores were higher with a lower number of tracts in all adolescents. In symptom-free community adolescents, a region of lower white matter (WM) integrity in the pons at age 14 was associated with current HD and predicted HD at age 16. HD was related to reward sensitivity.
Autres résumés
Type: Publisher
(fre)
The cortical-cerebellar circuit is vulnerable to heavy drinking (HD) in adults. We hypothesized early microstructural modifications of the pons/midbrain region, containing core structures of the reward system, in HD adolescents. Thirty-two otherwise symptom-free HDs at age 14 (HD14) and 24 abstainers becoming HDs at age 16 (HD16) were identified in the community with the Alcohol Use Disorders Identification Test (AUDIT) and compared with abstainers. The monetary incentive delay (MID) task assessed reward-sensitive performance. Voxelwise statistics of diffusion tensor imaging (DTI) values in the thalamo-ponto-mesencephalic region were obtained using tract-based spatial statistics. Projections between the ventral tegmental area (VTA) and the nucleus accumbens (NAcc) were identified by probabilistic tractography. Lower fraction of anisotropy and higher radial diffusivity (RD) values were detected in the upper dorsal pons of HD14 adolescents, and a trend for higher RD in HD16, compared with abstainers. When expecting reward, HD14 had higher MID task success scores than abstainers, and success scores were higher with a lower number of tracts in all adolescents. In symptom-free community adolescents, a region of lower white matter (WM) integrity in the pons at age 14 was associated with current HD and predicted HD at age 16. HD was related to reward sensitivity.
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e12781Subventions
Organisme : NIBIB NIH HHS
ID : U54 EB020403
Pays : United States
Organisme : Medical Research Council
ID : MR/N000390/1
Pays : United Kingdom
Organisme : NIMH NIH HHS
ID : R01 MH085772
Pays : United States
Informations de copyright
© 2019 Society for the Study of Addiction.
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