Manganese-enhanced MRI of the myocardium.
Animals
Calcium Signaling
Cardiomyopathies
/ diagnostic imaging
Contrast Media
/ administration & dosage
Edetic Acid
/ administration & dosage
Humans
Magnetic Resonance Imaging
Manganese
/ administration & dosage
Myocardium
/ metabolism
Predictive Value of Tests
Prognosis
Pyridoxal Phosphate
/ administration & dosage
Tissue Survival
MEMRI
manganese-enhanced MRI
viability
Journal
Heart (British Cardiac Society)
ISSN: 1468-201X
Titre abrégé: Heart
Pays: England
ID NLM: 9602087
Informations de publication
Date de publication:
11 2019
11 2019
Historique:
received:
11
04
2019
revised:
20
06
2019
accepted:
24
06
2019
pubmed:
25
7
2019
medline:
17
6
2020
entrez:
25
7
2019
Statut:
ppublish
Résumé
Gadolinium-based contrast media are widely used in cardiovascular MRI to identify and to highlight the intravascular and extracellular space. After gadolinium, manganese has the second highest paramagnetic moment and was one of the first MRI contrast agents assessed in humans. Over the last 50 years, manganese-enhanced MRI (MEMRI) has emerged as a complementary approach enabling intracellular myocardial contrast imaging that can identify functional myocardium through its ability to act as a calcium analogue. Early progress was limited by its potential to cause myocardial depression. To overcome this problem, two clinical formulations of manganese were developed using either chelation (manganese dipyridoxyl diphosphate) or coadministration with a calcium compound (EVP1001-1, Eagle Vision Pharmaceuticals). Preclinical studies have demonstrated the efficacy of MEMRI in quantifying myocardial infarction and detecting myocardial viability as well as tracking altered contractility and calcium handling in cardiomyopathy. Recent clinical data suggest that MEMRI has exciting potential in the quantification of myocardial viability in ischaemic cardiomyopathy, the early detection of abnormalities in myocardial calcium handling, and ultimately, in the development of novel therapies for myocardial infarction or heart failure by actively quantifying viable myocardium. The stage is now set for wider clinical translational study of this novel and promising non-invasive imaging modality.
Identifiants
pubmed: 31337670
pii: heartjnl-2019-315227
doi: 10.1136/heartjnl-2019-315227
pmc: PMC6855794
doi:
Substances chimiques
Contrast Media
0
EVP 1001-1
0
Manganese
42Z2K6ZL8P
Pyridoxal Phosphate
5V5IOJ8338
Edetic Acid
9G34HU7RV0
N,N'-bis(pyridoxal-5-phosphate)ethylenediamine-N,N'-diacetic acid
P28BIW0UTB
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1695-1700Subventions
Organisme : British Heart Foundation
ID : FS/17/19/32641
Pays : United Kingdom
Organisme : British Heart Foundation
ID : RG/16/10/32375
Pays : United Kingdom
Organisme : Wellcome Trust
ID : WT103782AIA
Pays : United Kingdom
Organisme : Medical Research Council
ID : G0701127
Pays : United Kingdom
Organisme : British Heart Foundation
ID : FS/14/78/31020
Pays : United Kingdom
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : British Heart Foundation
ID : CH/09/002
Pays : United Kingdom
Organisme : British Heart Foundation
ID : RM/13/2/30158
Pays : United Kingdom
Organisme : British Heart Foundation
ID : RG/14/3/30706
Pays : United Kingdom
Organisme : British Heart Foundation
ID : RE/13/3/30183
Pays : United Kingdom
Informations de copyright
© Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY. Published by BMJ.
Déclaration de conflit d'intérêts
Competing interests: None declared.
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