Therapeutic Ligands Antagonize Estrogen Receptor Function by Impairing Its Mobility.

Animals Breast Neoplasms / drug therapy Cell Proliferation / drug effects Cinnamates / pharmacology Drug Resistance, Neoplasm Estrogen Receptor Antagonists / pharmacology Female Fulvestrant / pharmacology HEK293 Cells Heterografts Humans Indazoles / pharmacology Ligands MCF-7 Cells Mice Mice, Inbred NOD Mice, Nude Mice, SCID Polymorphism, Single Nucleotide Proteolysis / drug effects Receptors, Estrogen / antagonists & inhibitors Signal Transduction / drug effects Transcription, Genetic / drug effects
ER SERD breast cancer chromatin estrogen receptor fulvestrant immobilization selective ER downregulator transcription

Journal

Cell
ISSN: 1097-4172
Titre abrégé: Cell
Pays: United States
ID NLM: 0413066

Informations de publication

Date de publication:
08 08 2019
Historique:
received: 29 08 2018
revised: 28 03 2019
accepted: 17 06 2019
pubmed: 30 7 2019
medline: 10 5 2020
entrez: 30 7 2019
Statut: ppublish

Résumé

Estrogen receptor-positive (ER

Identifiants

DOI: 10.1016/j.cell.2019.06.026 PMID: 31353221
pubmed: 31353221
pii: S0092-8674(19)30689-0
doi: 10.1016/j.cell.2019.06.026
pii:
doi:

Substances chimiques

3-(4-(2-(2-chloro-4-fluorophenyl)-1-(1H-indazol-5-yl)but-1-en-1-yl)phenyl)acrylic acid 0
Cinnamates 0
Estrogen Receptor Antagonists 0
Indazoles 0
Ligands 0
Receptors, Estrogen 0
Fulvestrant 22X328QOC4

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

949-963.e18

Informations de copyright

Copyright © 2019 Elsevier Inc. All rights reserved.

Auteurs

Jane Guan (J)

Department of Translational Oncology, Genentech, South San Francisco, CA 94080, USA.

Wei Zhou (W)

Department of Translational Oncology, Genentech, South San Francisco, CA 94080, USA.

Marc Hafner (M)

Department of Bioinformatics and Computational Biology, Genentech, South San Francisco, CA 94080, USA.

Robert A Blake (RA)

Department of Biochemical and Cellular Pharmacology, Genentech, South San Francisco, CA 94080, USA.

Cecile Chalouni (C)

Department of Pathology, Genentech, South San Francisco, CA 94080, USA.

Irene P Chen (IP)

Department of Medicine, UCSF, San Francisco, CA 94143, USA.

Tom De Bruyn (T)

Department of Drug Metabolism and Pharmacokinetics, Genentech, South San Francisco, CA 94080, USA.

Jennifer M Giltnane (JM)

Department of Pathology, Genentech, South San Francisco, CA 94080, USA.

Steven J Hartman (SJ)

Theravance Biopharma, South San Francisco, CA 94080, USA.

Amy Heidersbach (A)

Department of Molecular Biology, Genentech, South San Francisco, CA 94080, USA.

Rene Houtman (R)

Department of Research and Development, PamGene, 5211 HH's-Hertogenbosch, the Netherlands.

Ellen Ingalla (E)

Department of Translational Oncology, Genentech, South San Francisco, CA 94080, USA.

Lorn Kategaya (L)

Ideaya Biosciences, South San Francisco, CA 94080, USA.

Tracy Kleinheinz (T)

Department of Biochemical and Cellular Pharmacology, Genentech, South San Francisco, CA 94080, USA.

Jun Li (J)

Department of Discovery Chemistry, Genentech, South San Francisco, CA 94080, USA.

Scott E Martin (SE)

Department of Discovery Oncology, Genentech, South San Francisco, CA 94080, USA.

Zora Modrusan (Z)

Department of Molecular Biology, Genentech, South San Francisco, CA 94080, USA.

Michelle Nannini (M)

Department of Translational Oncology, Genentech, South San Francisco, CA 94080, USA.

Jason Oeh (J)

Department of Translational Oncology, Genentech, South San Francisco, CA 94080, USA.

Savita Ubhayakar (S)

Department of Medicine, UCSF, San Francisco, CA 94143, USA.

Xiaojing Wang (X)

Department of Discovery Chemistry, Genentech, South San Francisco, CA 94080, USA.

Ingrid E Wertz (IE)

Department of Discovery Oncology, Genentech, South San Francisco, CA 94080, USA.

Amy Young (A)

Department of Translational Oncology, Genentech, South San Francisco, CA 94080, USA.

Mamie Yu (M)

Department of Discovery Oncology, Genentech, South San Francisco, CA 94080, USA.

Deepak Sampath (D)

Department of Research, Ultragenyx, Novato, CA 94949, USA.

Jeffrey H Hager (JH)

Ideaya Biosciences, South San Francisco, CA 94080, USA.

Lori S Friedman (LS)

Department of Translational Oncology, Genentech, South San Francisco, CA 94080, USA.

Anneleen Daemen (A)

Department of Bioinformatics and Computational Biology, Genentech, South San Francisco, CA 94080, USA.

Ciara Metcalfe (C)

Department of Translational Oncology, Genentech, South San Francisco, CA 94080, USA. Electronic address: metcalfe.ciara@gene.com.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Therapeutic Ligands Antagonize Estrogen...
questionsmedicales.fr › Maladies de la peau et du tissu conjonctif › Maladies de la peau › Maladies du sein › Tumeurs du sein › Therapeutic Ligands Antagonize Estrogen...
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Croissance › Processus de croissance cellulaire › Prolifération cellulaire › Therapeutic Ligands Antagonize Estrogen...
questionsmedicales.fr › Composés chimiques organiques › Acides carboxyliques › Acides carbocycliques › Cinnamates › Therapeutic Ligands Antagonize Estrogen...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Résistance aux substances › Résistance aux médicaments antinéoplasiques › Therapeutic Ligands Antagonize Estrogen...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Hormones, substituts d'hormones et antagonistes d'hormones › Antihormones › Antagonistes des oestrogènes › Antagonistes des récepteurs des oestrogènes › Therapeutic Ligands Antagonize Estrogen...
questionsmedicales.fr › Hormones gonadiques › Hormones sexuelles stéroïdiennes › Congénères de l'oestradiol › Oestradiol › Fulvestrant › Therapeutic Ligands Antagonize Estrogen...
questionsmedicales.fr › Cellules › Cellules épithéliales › Cellules HEK293 › Therapeutic Ligands Antagonize Estrogen...
questionsmedicales.fr › Régions du corps › Transplants › Hétérogreffes › Therapeutic Ligands Antagonize Estrogen...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Therapeutic Ligands Antagonize Estrogen...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Indazoles › Therapeutic Ligands Antagonize Estrogen...
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Produits chimiques de laboratoire › Ligands › Therapeutic Ligands Antagonize Estrogen...
questionsmedicales.fr › Cellules › Cellules cultivées › Lignée cellulaire › Cellules MCF-7 › Therapeutic Ligands Antagonize Estrogen...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Therapeutic Ligands Antagonize Estrogen...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée NOD › Therapeutic Ligands Antagonize Estrogen...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souches mutantes de souris › Souris nude › Therapeutic Ligands Antagonize Estrogen...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souches mutantes de souris › Souris SCID › Therapeutic Ligands Antagonize Estrogen...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Polymorphisme génétique › Polymorphisme de nucléotide simple › Therapeutic Ligands Antagonize Estrogen...
questionsmedicales.fr › Métabolisme › Protéolyse › Therapeutic Ligands Antagonize Estrogen...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Récepteurs aux stéroïdes › Récepteurs des oestrogènes › Therapeutic Ligands Antagonize Estrogen...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › Therapeutic Ligands Antagonize Estrogen...
questionsmedicales.fr › Phénomènes génétiques › Expression des gènes › Transcription génétique › Therapeutic Ligands Antagonize Estrogen...