Genomic and antigenic characterization of a cytopathic bovine viral diarrhea virus 1i isolated in the United States.

Animals Antigens, Viral / genetics Aspartate Aminotransferases / blood California Cattle Cattle Diseases / virology Cluster Analysis Cytopathogenic Effect, Viral Diarrhea / veterinary Diarrhea Virus 1, Bovine Viral / genetics Genome, Viral Genotype Neutralization Tests Phylogeny Whole Genome Sequencing
Antigenic cross-reactivity Cytopathology Emerging virus Genomic duplication

Journal

Virology
ISSN: 1096-0341
Titre abrégé: Virology
Pays: United States
ID NLM: 0110674

Informations de publication

Date de publication:
09 2019
Historique:
received: 26 06 2019
revised: 23 07 2019
accepted: 23 07 2019
pubmed: 30 7 2019
medline: 9 4 2020
entrez: 30 7 2019
Statut: ppublish

Résumé

Bovine viral diarrhea viruses (BVDV) are a common global viral pathogen of ruminants. Considerable genetic variability is found amongst BVDV1 isolates, with at least 21 subgenotypes being described. In the United States, BVDV1a and 1b are the only subgenotypes described to date. Here, the genomic sequence of CA2005, a cytopathic BVDV1, was determined. This virus, isolated in California, did not segregate into either BVDV1a or 1b subgenotypes. BLAST analysis showed CA2005 was most closely related to BVDV1i isolates. CA2005 was also the first cytopathic BVDV1i and one of few non-1a, non-1b cytopathic viruses reported. The genomic sequence was 15,752 nucleotides in length. Cytopathogenicity was conferred by duplication of the NS3 protein with a small ubiquitin B insertion at the border of the NS2/NS3 proteins. Virus neutralization assays using antisera against BVDV1a vaccine viruses revealed variable neutralization, suggesting modified live vaccines may not be totally protective against CA2005 and similar viruses.

Identifiants

DOI: 10.1016/j.virol.2019.07.020 PMID: 31357167
pubmed: 31357167
pii: S0042-6822(19)30195-3
doi: 10.1016/j.virol.2019.07.020
pii:
doi:

Substances chimiques

Antigens, Viral 0
Aspartate Aminotransferases EC 2.6.1.1

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

279-282

Informations de copyright

Copyright © 2019 The Authors. Published by Elsevier Inc. All rights reserved.

Auteurs

John D Neill (JD)

USDA, Agricultural Research Service, National Animal Disease Center, Ruminant Diseases and Immunology Research Unit, 1920 Dayton Ave., Ames, IA, 50010, USA. Electronic address: john.neill@ars.gov.

Beate M Crossley (BM)

California Animal Health and Food Safety Laboratory System, Davis Branch, University of California, Davis, CA, 95616, USA.

Ana C Mosena (AC)

Laboratorio de Virologia, Faculdade de Veterinaria, Universidade Federal Do Rio Grande Do Sul (UFRGS), Porto Alegre, Rio Grande Do Sul, Brazil.

Julia F Ridpath (JF)

USDA, Agricultural Research Service, National Animal Disease Center, Ruminant Diseases and Immunology Research Unit, 1920 Dayton Ave., Ames, IA, 50010, USA.

Darrell O Bayles (DO)

USDA, Agricultural Research Service, National Animal Disease Center, Bacterial Diseases Research Unit, 1920 Dayton Ave., Ames, IA, 50010, USA.

Sharon K Hietala (SK)

California Animal Health and Food Safety Laboratory System, Davis Branch, University of California, Davis, CA, 95616, USA.

Mary Lea Killian (ML)

USDA, Animal and Plant Inspection Service, National Veterinary Services Laboratory, 1920 Dayton Ave., Ames, IA, 50010, USA.

Shollie M Falkenberg (SM)

USDA, Agricultural Research Service, National Animal Disease Center, Ruminant Diseases and Immunology Research Unit, 1920 Dayton Ave., Ames, IA, 50010, USA.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Genomic and antigenic characterization of a...
questionsmedicales.fr › Facteurs biologiques › Antigènes › Antigènes viraux › Genomic and antigenic characterization of a...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Transferases › Nitrogenous group transferases › Transaminases › Aspartate aminotransferases › Genomic and antigenic characterization of a...
questionsmedicales.fr › Régions géographiques › Amériques › Amérique du Nord › États-Unis › États du Sud-Ouest des États-Unis › Californie › Genomic and antigenic characterization of a...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Artiodactyla › Ruminants › Bovins › Genomic and antigenic characterization of a...
questionsmedicales.fr › Maladies de l'animal › Maladies des bovins › Genomic and antigenic characterization of a...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Analyse de regroupements › Genomic and antigenic characterization of a...
questionsmedicales.fr › Phénomènes microbiologiques › Phénomènes physiologiques viraux › Effet cytopathogène viral › Genomic and antigenic characterization of a...
questionsmedicales.fr › États, signes et symptômes pathologiques › Signes et symptômes › Signes et symptômes digestifs › Diarrhée › Genomic and antigenic characterization of a...
questionsmedicales.fr › Virus › Virus à ARN › Virus à ARN à brin positif › Flaviviridae › Pestivirus › Virus de la diarrhée virale bovine › Virus de la diarrhée virale bovine de type 1 › Genomic and antigenic characterization of a...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Génome microbien › Génome viral › Genomic and antigenic characterization of a...
questionsmedicales.fr › Phénomènes génétiques › Génotype › Genomic and antigenic characterization of a...
questionsmedicales.fr › Techniques d'investigation › Techniques immunologiques › Tests immunologiques › Tests sérologiques › Tests de neutralisation › Genomic and antigenic characterization of a...
questionsmedicales.fr › Sciences de l'information › Phylogenèse › Genomic and antigenic characterization of a...
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Analyse de séquence › Analyse de séquence d'ADN › Séquençage du génome entier › Genomic and antigenic characterization of a...