Spatiotemporal Dynamics of Synthetic Microbial Consortia in Microfluidic Devices.
microbial consortia
microfluidics
spatiotemporal patterning
Journal
ACS synthetic biology
ISSN: 2161-5063
Titre abrégé: ACS Synth Biol
Pays: United States
ID NLM: 101575075
Informations de publication
Date de publication:
20 09 2019
20 09 2019
Historique:
pubmed:
31
7
2019
medline:
3
7
2020
entrez:
31
7
2019
Statut:
ppublish
Résumé
Synthetic microbial consortia consist of two or more engineered strains that grow together and share the same resources. When intercellular signaling pathways are included in the engineered strains, close proximity of the microbes can generate complex dynamic behaviors that are difficult to obtain using a single strain. However, when a consortium is not cultured in a well-mixed environment the constituent strains passively compete for space as they grow and divide, complicating cell-cell signaling. Here, we explore the temporal dynamics of the spatial distribution of consortia cocultured in microfluidic devices. To do this, we grew two different strains of
Identifiants
pubmed: 31361464
doi: 10.1021/acssynbio.9b00146
pmc: PMC6754295
mid: NIHMS1044594
doi:
Substances chimiques
Luminescent Proteins
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
2051-2058Subventions
Organisme : NIGMS NIH HHS
ID : R01 GM104974
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM117138
Pays : United States
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