Precision Medicine for Idiopathic Hypersomnia.

Central Nervous System Stimulants / therapeutic use Clarithromycin / therapeutic use Flumazenil / therapeutic use GABA Modulators / therapeutic use Humans Idiopathic Hypersomnia / drug therapy Mazindol / therapeutic use Modafinil / therapeutic use Orexins / metabolism Piperidines / therapeutic use Polysomnography Precision Medicine Sleep Sodium Oxybate / therapeutic use Wakefulness Wakefulness-Promoting Agents / therapeutic use
Drowsiness GABA Hypersomnia Long sleep time Modafinil Sodium oxybate

Journal

Sleep medicine clinics
ISSN: 1556-4088
Titre abrégé: Sleep Med Clin
Pays: United States
ID NLM: 101271531

Informations de publication

Date de publication:
Sep 2019
Historique:
entrez: 4 8 2019
pubmed: 4 8 2019
medline: 18 12 2019
Statut: ppublish

Résumé

Idiopathic hypersomnia (IH) is characterized by excessive daytime sleepiness despite normal or prolonged sleep. IH is distinguished from narcolepsy by the female predominance, severe morning inertia, continuous drowsiness (rather than sleep attacks), unrefreshing naps, absence of cataplexy, sleep onset in REM periods, and hypocretin deficiency. In IH, the multiple sleep latency test demonstrates low sensitivity, specificity, and reproducibility, compared with prolonged sleep monitoring. In some IH cases, an endogenous hypnotic peptide stimulating GABA receptors during wakefulness is suspected, which are improved by anti-GABA drugs. The benefits of modafinil, sodium oxybate, mazindol, and pitolisant were found in mostly retrospective studies.

Identifiants

DOI: 10.1016/j.jsmc.2019.05.007 PMID: 31375202
pubmed: 31375202
pii: S1556-407X(19)30048-7
doi: 10.1016/j.jsmc.2019.05.007
pii:
doi:

Substances chimiques

Central Nervous System Stimulants 0
GABA Modulators 0
HCRT protein, human 0
Orexins 0
Piperidines 0
Wakefulness-Promoting Agents 0
Flumazenil 40P7XK9392
pitolisant 4BC83L4PIY
Sodium Oxybate 7G33012534
Mazindol C56709M5NH
Clarithromycin H1250JIK0A
Modafinil R3UK8X3U3D

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

333-350

Informations de copyright

Copyright © 2019 Elsevier Inc. All rights reserved.

Auteurs

Isabelle Arnulf (I)

National Reference Center for Rare Hypersomnias, Pitie-Salpetriere University Hospital, APHP, and Sorbonne University, 47-83 Boulevard de l'Hôpital, Paris 75013, France. Electronic address: isabelle.arnulf@aphp.fr.

Smaranda Leu-Semenescu (S)

National Reference Center for Rare Hypersomnias, Pitie-Salpetriere University Hospital, APHP, and Sorbonne University, 47-83 Boulevard de l'Hôpital, Paris 75013, France.

Pauline Dodet (P)

National Reference Center for Rare Hypersomnias, Pitie-Salpetriere University Hospital, APHP, and Sorbonne University, 47-83 Boulevard de l'Hôpital, Paris 75013, France.

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Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Agents du système nerveux central › Stimulants du système nerveux central › Precision Medicine for Idiopathic Hypersomnia.
questionsmedicales.fr › Composés chimiques organiques › Lactones › Érythromycine › Clarithromycine › Precision Medicine for Idiopathic Hypersomnia.
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Benzazépines › Benzodiazépines › Benzodiazépinones › Flumazénil › Precision Medicine for Idiopathic Hypersomnia.
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Agents neuromédiateurs › Agents GABA › Modulateurs GABA › Precision Medicine for Idiopathic Hypersomnia.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Precision Medicine for Idiopathic Hypersomnia.
questionsmedicales.fr › Troubles mentaux › Troubles de la veille et du sommeil › Dyssomnies › Troubles du sommeil d'origine intrinsèque › Troubles du sommeil par somnolence excessive › Hypersomnie idiopathique › Precision Medicine for Idiopathic Hypersomnia.
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Isoindoles › Mazindol › Precision Medicine for Idiopathic Hypersomnia.
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Hydrocarbures cycliques › Hydrocarbures aromatiques › Dérivés du benzène › Composés benzhydryliques › Modafinil › Precision Medicine for Idiopathic Hypersomnia.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de tissu nerveux › Neuropeptides › Orexines › Precision Medicine for Idiopathic Hypersomnia.
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Pipéridines › Precision Medicine for Idiopathic Hypersomnia.
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Monitorage physiologique › Polysomnographie › Precision Medicine for Idiopathic Hypersomnia.
questionsmedicales.fr › Professions de santé › Médecine › Médecine clinique › Médecine de précision › Precision Medicine for Idiopathic Hypersomnia.
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système nerveux › Sommeil › Precision Medicine for Idiopathic Hypersomnia.
questionsmedicales.fr › Composés chimiques organiques › Acides carboxyliques › Hydroxyacides › Oxybate de sodium › Precision Medicine for Idiopathic Hypersomnia.
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système nerveux › Éveil › Vigilance › Precision Medicine for Idiopathic Hypersomnia.
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Agents du système nerveux central › Stimulants du système nerveux central › Agents promoteurs de l'éveil › Precision Medicine for Idiopathic Hypersomnia.