SNAI1 Promotes the Cholangiocellular Phenotype, but not Epithelial-Mesenchymal Transition, in a Murine Hepatocellular Carcinoma Model.

Animals Cadherins / genetics Carcinoma, Hepatocellular / genetics Cell Movement / genetics Cholangiocarcinoma / genetics Disease Models, Animal Epithelial-Mesenchymal Transition / genetics Gene Expression Regulation, Neoplastic / genetics Humans Liver Neoplasms / genetics Mice Phenotype Proto-Oncogene Proteins c-akt / genetics Proto-Oncogene Proteins c-met / genetics Snail Family Transcription Factors / genetics Vimentin / genetics

Journal

Cancer research
ISSN: 1538-7445
Titre abrégé: Cancer Res
Pays: United States
ID NLM: 2984705R

Informations de publication

Date de publication:
01 11 2019
Historique:
received: 15 12 2018
revised: 29 06 2019
accepted: 30 07 2019
pubmed: 7 8 2019
medline: 29 5 2020
entrez: 7 8 2019
Statut: ppublish

Résumé

Hepatocellular carcinoma (HCC) is the most common type of liver cancer and has limited treatment options. Snail family transcriptional repressor 1 (SNAI1) is a master regulator of epithelial-mesenchymal transition (EMT) and has been implicated in HCC initiation and progression. However, the precise role of SNAI1 and the way it contributes to hepatocarcinogenesis have not been investigated in depth, especially

Identifiants

DOI: 10.1158/0008-5472.CAN-18-3750 PMID: 31383647 PMC: PMC7237201
pubmed: 31383647
pii: 0008-5472.CAN-18-3750
doi: 10.1158/0008-5472.CAN-18-3750
pmc: PMC7237201
mid: NIHMS1581867
doi:

Substances chimiques

Cadherins 0
SNAI1 protein, human 0
Snai1 protein, mouse 0
Snail Family Transcription Factors 0
Vimentin 0
Proto-Oncogene Proteins c-met EC 2.7.10.1
Proto-Oncogene Proteins c-akt EC 2.7.11.1

Types de publication

Journal Article Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

5563-5574

Subventions

Organisme : NIDDK NIH HHS
ID : P30 DK026743
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA136606
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA190606
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA228483
Pays : United States

Informations de copyright

©2019 American Association for Cancer Research.

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Auteurs

Meng Xu (M)

Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an Jiaotong University, Xi'an, P. R. China.
Department of General Surgery, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an Jiaotong University, Xi'an, P. R. China.
Department of Bioengineering and Therapeutic Sciences and Liver Center, University of California, San Francisco, California.
ORCID: 0000-0001-7565-6053

Jingxiao Wang (J)

Department of Bioengineering and Therapeutic Sciences and Liver Center, University of California, San Francisco, California.
School of Life Sciences, Beijing University of Chinese Medicine, Beijing, PR China.

Zhong Xu (Z)

Department of Gastroenterology, Guizhou Provincial People's Hospital, Medical College of Guizhou University, Guiyang, P. R. China.
ORCID: 0000-0001-7565-6053

Rong Li (R)

Department of Anesthesiology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, P. R. China.

Pan Wang (P)

Department of Bioengineering and Therapeutic Sciences and Liver Center, University of California, San Francisco, California.
Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Food Science and Nutritional Engineering.

Runze Shang (R)

Department of Bioengineering and Therapeutic Sciences and Liver Center, University of California, San Francisco, California.
Department of Hepatobiliary Surgery, Xi'jing Hospital, Air Force Military Medical University, Xi'an, P. R. China.

Antonio Cigliano (A)

Institute of Pathology, University Clinic of Regensburg, Regensburg, Germany.
ORCID: 0000-0002-6408-3613

Silvia Ribback (S)

Institute of Pathology, University of Greifswald, Greifswald, Germany.

Antonio Solinas (A)

Department of Biomedical Sciences, University of Sassari, Sassari, Italy.

Giovanni Mario Pes (GM)

Department of Medical, Surgical and Experimental Sciences, University of Sassari, Sassari, Italy.
ORCID: 0000-0003-3265-2823

Katja Evert (K)

Institute of Pathology, University Clinic of Regensburg, Regensburg, Germany.

Haichuan Wang (H)

Department of Bioengineering and Therapeutic Sciences and Liver Center, University of California, San Francisco, California.
Liver Transplantation Division, Department of Liver Surgery, West China Hospital, Sichuan University, Chengdu, P. R. China.

Xinhua Song (X)

Department of Bioengineering and Therapeutic Sciences and Liver Center, University of California, San Francisco, California.

Shu Zhang (S)

Department of Bioengineering and Therapeutic Sciences and Liver Center, University of California, San Francisco, California.
Department of Radiation Oncology and Department of Head and Neck Oncology, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, P. R. China.

Li Che (L)

Department of Bioengineering and Therapeutic Sciences and Liver Center, University of California, San Francisco, California.

Rosa Maria Pascale (RM)

Department of Medical, Surgical and Experimental Sciences, University of Sassari, Sassari, Italy.
ORCID: 0000-0001-7612-3646

Diego Francesco Calvisi (DF)

Institute of Pathology, University Clinic of Regensburg, Regensburg, Germany. liuqingguang@vip.sina.com diego.calvisi@klinik.uni-regensburg.de.
Institute of Pathology, University of Greifswald, Greifswald, Germany.

Qingguang Liu (Q)

Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an Jiaotong University, Xi'an, P. R. China. liuqingguang@vip.sina.com diego.calvisi@klinik.uni-regensburg.de.

Xin Chen (X)

Department of Bioengineering and Therapeutic Sciences and Liver Center, University of California, San Francisco, California.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › SNAI1 Promotes the Cholangiocellular...
questionsmedicales.fr › Facteurs biologiques › Antigènes › Antigènes de surface › Molécules d'adhérence cellulaire › Cadhérines › SNAI1 Promotes the Cholangiocellular...
questionsmedicales.fr › Maladies de l'appareil digestif › Maladies du foie › Tumeurs du foie › Carcinome hépatocellulaire › SNAI1 Promotes the Cholangiocellular...
questionsmedicales.fr › Phénomènes physiologiques › Mouvement cellulaire › SNAI1 Promotes the Cholangiocellular...
questionsmedicales.fr › Tumeurs › Tumeurs par type histologique › Tumeurs épithéliales épidermoïdes et glandulaires › Carcinomes › Adénocarcinome › Cholangiocarcinome › SNAI1 Promotes the Cholangiocellular...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › SNAI1 Promotes the Cholangiocellular...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transdifférenciation cellulaire › Transition épithélio-mésenchymateuse › SNAI1 Promotes the Cholangiocellular...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Régulation de l'expression des gènes tumoraux › SNAI1 Promotes the Cholangiocellular...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › SNAI1 Promotes the Cholangiocellular...
questionsmedicales.fr › Maladies de l'appareil digestif › Maladies du foie › Tumeurs du foie › SNAI1 Promotes the Cholangiocellular...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › SNAI1 Promotes the Cholangiocellular...
questionsmedicales.fr › Phénomènes génétiques › Phénotype › SNAI1 Promotes the Cholangiocellular...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines tumorales › Protéines oncogènes › Protéines proto-oncogènes › Protéines proto-oncogènes c-akt › SNAI1 Promotes the Cholangiocellular...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines tumorales › Protéines oncogènes › Protéines proto-oncogènes › Protéines proto-oncogènes c-met › SNAI1 Promotes the Cholangiocellular...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Facteurs de transcription de la famille Snail › SNAI1 Promotes the Cholangiocellular...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines du cytosquelette › Protéines de filaments intermédiaires › Vimentine › SNAI1 Promotes the Cholangiocellular...