Neuroanatomical correlates of personality traits in temporal lobe epilepsy: Findings from the Epilepsy Connectome Project.
Adult
Amygdala
/ diagnostic imaging
Brain
/ diagnostic imaging
Connectome
/ methods
Epilepsy, Temporal Lobe
/ diagnostic imaging
Female
Gray Matter
/ diagnostic imaging
Humans
Magnetic Resonance Imaging
/ methods
Male
Middle Aged
Neuroticism
/ physiology
Personality
/ physiology
Personality Inventory
Big 5 traits
NEO-Five Factor Inventory
Personality
Temporal lobe epilepsy
Journal
Epilepsy & behavior : E&B
ISSN: 1525-5069
Titre abrégé: Epilepsy Behav
Pays: United States
ID NLM: 100892858
Informations de publication
Date de publication:
09 2019
09 2019
Historique:
received:
03
03
2019
revised:
15
05
2019
accepted:
05
07
2019
pubmed:
7
8
2019
medline:
9
7
2020
entrez:
7
8
2019
Statut:
ppublish
Résumé
Behavioral and personality disorders in temporal lobe epilepsy (TLE) have been a topic of interest and controversy for decades, with less attention paid to alterations in normal personality structure and traits. In this investigation, core personality traits (the Big 5) and their neurobiological correlates in TLE were explored using the Neuroticism Extraversion Openness-Five Factor Inventory (NEO-FFI) and structural magnetic resonance imaging (MRI) through the Epilepsy Connectome Project (ECP). NEO-FFI scores from 67 individuals with TLE (34.6 ± 9.5 years; 67% women) were compared to 31 healthy controls (32.8 ± 8.9 years; 41% women) to assess differences in the Big 5 traits (agreeableness, openness, conscientiousness, neuroticism, and extraversion). Individuals with TLE showed significantly higher neuroticism, with no significant differences on the other traits. Neural correlates of neuroticism were then determined in participants with TLE including cortical and subcortical volumes. Distributed reductions in cortical gray matter volumes were associated with increased neuroticism. Subcortically, hippocampal and amygdala volumes were negatively associated with neuroticism. These results offer insight into alterations in the Big 5 personality traits in TLE and their brain-related correlates.
Identifiants
pubmed: 31387000
pii: S1525-5050(19)30210-0
doi: 10.1016/j.yebeh.2019.07.025
pmc: PMC6732015
mid: NIHMS1534526
pii:
doi:
Types de publication
Journal Article
Multicenter Study
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
220-227Subventions
Organisme : NINDS NIH HHS
ID : U01 NS093650
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS111022
Pays : United States
Organisme : NCI NIH HHS
ID : T32 CA009206
Pays : United States
Organisme : NIMH NIH HHS
ID : T32 MH018931
Pays : United States
Organisme : NICHD NIH HHS
ID : U54 HD090256
Pays : United States
Informations de copyright
Copyright © 2019 Elsevier Inc. All rights reserved.
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