Phosphoinositide-3 kinase gamma regulates caspase-1 activation and leukocyte recruitment in acute murine gout.
Acute Disease
Animals
Arthritis, Gouty
/ enzymology
Caspase 1
/ metabolism
Cell Adhesion
Cell Movement
Class Ib Phosphatidylinositol 3-Kinase
/ deficiency
Cytoplasm
/ metabolism
Enzyme Activation
Inflammasomes
/ metabolism
Inflammation
/ pathology
Interleukin-1beta
/ metabolism
Joints
/ pathology
Leukotriene B4
/ metabolism
Male
Mice, Inbred C57BL
Microvessels
/ pathology
Neutrophil Infiltration
Neutrophils
/ metabolism
Nociception
Phosphorylation
Proto-Oncogene Proteins c-akt
/ metabolism
Synovial Membrane
/ blood supply
Uric Acid
PI3Kγ
arthritis
gout
inflammasome
leukotriene B4
neutrophil
Journal
Journal of leukocyte biology
ISSN: 1938-3673
Titre abrégé: J Leukoc Biol
Pays: England
ID NLM: 8405628
Informations de publication
Date de publication:
09 2019
09 2019
Historique:
received:
04
01
2019
revised:
09
07
2019
accepted:
14
07
2019
pubmed:
9
8
2019
medline:
27
5
2020
entrez:
9
8
2019
Statut:
ppublish
Résumé
This study investigates the participation of PI3Kγ in the development of joint inflammation and dysfunction in an experimental model of acute gout in mice. Acute gout was induced by injection of monosodium urate (MSU) crystals into the tibiofemoral joint of mice. The involvement of PI3Kγ was evaluated using a selective inhibitor and mice deficient for PI3Kγ (PI3Kγ
Identifiants
pubmed: 31392775
doi: 10.1002/JLB.MA1118-470RR
doi:
Substances chimiques
Inflammasomes
0
Interleukin-1beta
0
Leukotriene B4
1HGW4DR56D
Uric Acid
268B43MJ25
Class Ib Phosphatidylinositol 3-Kinase
EC 2.7.1.137
Pik3cg protein, mouse
EC 2.7.1.153
Proto-Oncogene Proteins c-akt
EC 2.7.11.1
Caspase 1
EC 3.4.22.36
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
619-629Informations de copyright
©2019 Society for Leukocyte Biology.
Références
So AK, Martinon F. Inflammation in gout: mechanisms and therapeutic targets. Nat Rev Rheumatol. 2017;13:639-647.
So A. Developments in the scientific and clinical understanding of gout. Arthritis Res Ther. 2008;10:221.
Rock KL, Kataoka H, Lai JJ. Uric acid as a danger signal in gout and its comorbidities. Nat Rev Rheumatol. 2013;9:13-23.
Rees F, Hui M, Doherty M. Optimizing current treatment of gout. Nat Rev Rheumatol. 2014;10:271-283.
Gustafsson D, Unwin R. The pathophysiology of hyperuricaemia and its possible relationship to cardiovascular disease, morbidity and mortality. BMC Nephrol. 2013;14:164.
Singh JA. Racial and gender disparities among patients with gout. Curr Rheumatol Rep. 2013;15:307.
Akahoshi T, Murakami Y, Kitasato H. Recent advances in crystal-induced acute inflammation. Curr Opin Rheumatol. 2007;19:146-150.
Amaral FA, Costa VV, Tavares LD, et al. NLRP3 inflammasome-mediated neutrophil recruitment and hypernociception depend on leukotriene B(4) in a murine model of gout. Arthritis Rheum. 2012;64:474-484.
Cantley LC. The phosphoinositide 3-kinase pathway. Science. 2002;296:1655-1657.
Pinho V, Russo RC, Amaral FA, et al. Tissue- and stimulus-dependent role of phosphatidylinositol 3-kinase isoforms for neutrophil recruitment induced by chemoattractants in vivo. J Immunol. 2007;179:7891-7898.
Hirsch E, Katanaev VL, Garlanda C, et al. Central role for G protein-coupled phosphoinositide 3-kinase gamma in inflammation. Science. 2000;287:1049-1053.
Ruckle T, Schwarz MK, Rommel C. PI3Kgamma inhibition: towards an ‘aspirin of the 21st century’? Nat Rev Drug Discov. 2006;5:903-918.
Popa-Nita O, Rollet-Labelle E, Thibault N, Gilbert C, Bourgoin SG, Naccache PH. Crystal-induced neutrophil activation. IX. Syk-dependent activation of class Ia phosphatidylinositol 3-kinase. J Leukoc Biol. 2007;82:763-773.
Patrucco E, Notte A, Barberis L, et al. PI3Kgamma modulates the cardiac response to chronic pressure overload by distinct kinase-dependent and -independent effects. Cell. 2004;118:375-387.
Martin EL, Souza DG, Fagundes CT, et al. Phosphoinositide-3 kinase gamma activity contributes to sepsis and organ damage by altering neutrophil recruitment. Am J Respir Crit Care Med. 2010;182:762-773.
Sachs D, Coelho FM, Costa VV, et al. Cooperative role of tumour necrosis factor-alpha, interleukin-1beta and neutrophils in a novel behavioural model that concomitantly demonstrates articular inflammation and hypernociception in mice. Br J Pharmacol. 2011;162:72-83.
Queiroz-Junior CM, Madeira MF, Coelho FM, et al. Experimental arthritis triggers periodontal disease in mice: involvement of TNF-alpha and the oral microbiota. J Immunol. 2011;187:3821-3830.
Coelho FM, Pinho V, Amaral FA, et al. The chemokine receptors CXCR1/CXCR2 modulate antigen-induced arthritis by regulating adhesion of neutrophils to the synovial microvasculature. Arthritis Rheum. 2008;58:2329-2337.
Sousa LP, Lopes F, Silva DM, et al. PDE4 inhibition drives resolution of neutrophilic inflammation by inducing apoptosis in a PKA-PI3K/Akt-dependent and NF-kappaB-independent manner. J Leukoc Biol. 2010;87:895-904.
Cronstein BN, Terkeltaub R. The inflammatory process of gout and its treatment. Arthritis Res Ther. 2006;8(Suppl 1):S3.
Fumagalli L, Campa CC, Germena G, Lowell CA, Hirsch E, Berton G. Class I phosphoinositide-3-kinases and SRC kinases play a nonredundant role in regulation of adhesion-independent and -dependent neutrophil reactive oxygen species generation. J Immunol. 2013;190:3648-3660.
Boyle DL, Kim HR, Topolewski K, Bartok B, Firestein GS. Novel phosphoinositide 3-kinase δ,γ inhibitor: potent anti-inflammatory effects and joint protection in models of rheumatoid arthritis. J Pharmacol Exp Ther. 2014;348:271-280.
Martinon F, Petrilli V, Mayor A, Tardivel A, Tschopp J. Gout-associated uric acid crystals activate the NALP3 inflammasome. Nature. 2006;440:237-241.
Akasaki T, Koga H, Sumimoto H. Phosphoinositide 3-kinase-dependent and -independent activation of the small GTPase Rac2 in human neutrophils. J Biol Chem. 1999;274:18055-18059.
Hayer S, Pundt N, Peters MA, et al. PI3Kgamma regulates cartilage damage in chronic inflammatory arthritis. FASEB J. 2009;23:4288-4298.
Camps M, Ruckle T, Ji H, et al. Blockade of PI3Kgamma suppresses joint inflammation and damage in mouse models of rheumatoid arthritis. Nat Med. 2005;11:936-943.
Allaeys I, Marceau F, Poubelle PE. NLRP3 promotes autophagy of urate crystals phagocytized by human osteoblasts. Arthritis Res Ther. 2013;15:R176.
Galvao I, Queiroz-Junior CM, de Oliveira VLS, Pinho V, Hirsch E, Teixeira MM. The inhibition of phosphoinositide-3 kinases induce resolution of inflammation in a gout model. Front Pharmacol. 2018;9:1505.
Kuijk LM, Beekman JM, Koster J, Waterham HR, Frenkel J, Coffer PJ. HMG-CoA reductase inhibition induces IL-1beta release through Rac1/PI3K/PKB-dependent caspase-1 activation. Blood. 2008;112:3563-3573.
Liang J, Zhao H, Yao L, et al. Phosphatidylinositol 3-kinases pathway mediates lung caspase-1 activation and high mobility group box 1 production in a toluene-diisocyanate induced murine asthma model. Toxicol Lett. 2015;236:25-33.
Dostert C, Petrilli V, Van Bruggen R, Steele C, Mossman BT, Tschopp J. Innate immune activation through Nalp3 inflammasome sensing of asbestos and silica. Science. 2008;320:674-677.
Petrilli V, Papin S, Dostert C, Mayor A, Martinon F, Tschopp J. Activation of the NALP3 inflammasome is triggered by low intracellular potassium concentration. Cell Death Differ. 2007;14:1583-1589.
Randis TM, Puri KD, Zhou H, Diacovo TG. Role of PI3Kdelta and PI3Kgamma in inflammatory arthritis and tissue localization of neutrophils. Eur J Immunol. 2008;38:1215-1224.
Rae SA, Davidson EM, Smith MJ. Leukotriene B4, an inflammatory mediator in gout. Lancet. 1982;2:1122-1124.
George J, Struthers AD. Role of urate, xanthine oxidase and the effects of allopurinol in vascular oxidative stress. Vasc Health Risk Manag. 2009;5:265-272.
Ives A, Nomura J, Martinon F, et al. Xanthine oxidoreductase regulates macrophage IL1beta secretion upon NLRP3 inflammasome activation. Nat Commun. 2015;6:6555.
Terkeltaub R, Zachariae C, Santoro D, Martin J, Peveri P, Matsushima K. Monocyte-derived neutrophil chemotactic factor/interleukin-8 is a potential mediator of crystal-induced inflammation. Arthritis Rheum. 1991;34:894-903.
Terkeltaub R, Baird S, Sears P, Santiago R, Boisvert W. The murine homolog of the interleukin-8 receptor CXCR-2 is essential for the occurrence of neutrophilic inflammation in the air pouch model of acute urate crystal-induced gouty synovitis. Arthritis Rheum. 1998;41:900-909.
Kolaczkowska E, Kubes P. Neutrophil recruitment and function in health and inflammation. Nat Rev Immunol. 2013;13:159-175.
Ryckman C, McColl SR, Vandal K, et al. Role of S100A8 and S100A9 in neutrophil recruitment in response to monosodium urate monohydrate crystals in the air-pouch model of acute gouty arthritis. Arthritis Rheum. 2003;48:2310-2320.
Bertolotto M, Contini P, Ottonello L, Pende A, Dallegri F, Montecucco F. Neutrophil migration towards C5a and CXCL8 is prevented by non-steroidal anti-inflammatory drugs via inhibition of different pathways. Br J Pharmacol. 2014;171:3376-3393.
Handel TM, Johnson Z, Crown SE, Lau EK, Proudfoot AE. Regulation of protein function by glycosaminoglycans-as exemplified by chemokines. Annu Rev Biochem. 2005;74:385-410.
Ferguson GJ, Milne L, Kulkarni S, et al. PI(3)Kgamma has an important context-dependent role in neutrophil chemokinesis. Nat Cell Biol. 2007;9:86-91.
Ramonda R, Oliviero F, Galozzi P, et al. Molecular mechanisms of pain in crystal-induced arthritis. Best Pract Res Clin Rheumatol. 2015;29:98-110.
Cunha TM, Roman-Campos D, Lotufo CM, et al. Morphine peripheral analgesia depends on activation of the PI3Kgamma/AKT/nNOS/NO/KATP signaling pathway. Proc Natl Acad Sci USA. 2010;107:4442-4447.
Pritchard RA, Falk L, Larsson M, Leinders M, Sorkin LS. Different phosphoinositide 3-kinase isoforms mediate carrageenan nociception and inflammation. Pain. 2016;157:137-146.
Carvalho TT, Flauzino T, Otaguiri ES, et al. Granulocyte-colony stimulating factor (G-CSF) induces mechanical hyperalgesia via spinal activation of MAP kinases and PI3K in mice. Pharmacol Biochem Behav. 2011;98:188-195.
Pereira PJ, Lazarotto LF, Leal PC, Lopes TG, Morrone FB, Campos MM. Inhibition of phosphatidylinositol-3 kinase gamma reduces pruriceptive, inflammatory, and nociceptive responses induced by trypsin in mice. Pain. 2011;152:2861-2869.