The yeast pantothenate kinase Cab1 is a master regulator of sterol metabolism and of susceptibility to ergosterol biosynthesis inhibitors.
Amphotericin B
/ pharmacology
Antifungal Agents
/ pharmacology
Coenzyme A
/ biosynthesis
Drug Resistance, Fungal
/ genetics
Ergosterol
/ antagonists & inhibitors
Gene Expression Regulation, Fungal
/ drug effects
Genome, Fungal
/ drug effects
Pantothenic Acid
/ biosynthesis
Phosphotransferases (Alcohol Group Acceptor)
/ genetics
Saccharomyces cerevisiae
/ genetics
Sterols
/ biosynthesis
Terbinafine
/ pharmacology
antifungal
drug action
metabolic regulation
metabolism
pantothenate kinase
pantothenic acid
regulation
sterol
transcription regulation
yeast metabolism
Journal
The Journal of biological chemistry
ISSN: 1083-351X
Titre abrégé: J Biol Chem
Pays: United States
ID NLM: 2985121R
Informations de publication
Date de publication:
04 10 2019
04 10 2019
Historique:
received:
14
06
2019
revised:
12
08
2019
pubmed:
15
8
2019
medline:
7
5
2020
entrez:
15
8
2019
Statut:
ppublish
Résumé
In fungi, ergosterol is an essential component of the plasma membrane. Its biosynthesis from acetyl-CoA is the primary target of the most commonly used antifungal drugs. Here, we show that the pantothenate kinase Cab1p, which catalyzes the first step in the metabolism of pantothenic acid for CoA biosynthesis in budding yeast (
Identifiants
pubmed: 31409644
pii: S0021-9258(20)35024-9
doi: 10.1074/jbc.RA119.009791
pmc: PMC6779428
doi:
Substances chimiques
Antifungal Agents
0
Sterols
0
Pantothenic Acid
19F5HK2737
Amphotericin B
7XU7A7DROE
Phosphotransferases (Alcohol Group Acceptor)
EC 2.7.1.-
pantothenate kinase
EC 2.7.1.33
Terbinafine
G7RIW8S0XP
Coenzyme A
SAA04E81UX
Ergosterol
Z30RAY509F
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
14757-14767Subventions
Organisme : NIAID NIH HHS
ID : R01 AI097218
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI123321
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001863
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI138139
Pays : United States
Informations de copyright
© 2019 Chiu et al.
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