Reaction of thymidine and ascorbic acid induced by UV in the presence of salicylic acid.

Ascorbic Acid / chemistry Kinetics Photosensitizing Agents / chemistry Pyrimidine Dimers / chemical synthesis Salicylic Acid / chemistry Thymidine / chemistry Ultraviolet Rays
Ascorbic acid Salicylic acid Thymidine Ultraviolet light

Journal

Bioorganic & medicinal chemistry
ISSN: 1464-3391
Titre abrégé: Bioorg Med Chem
Pays: England
ID NLM: 9413298

Informations de publication

Date de publication:
01 10 2019
Historique:
received: 08 07 2019
revised: 27 07 2019
accepted: 07 08 2019
pubmed: 20 8 2019
medline: 21 10 2020
entrez: 19 8 2019
Statut: ppublish

Résumé

When a neutral solution of thymidine and ascorbic acid was irradiated with UV light of wavelength longer than 300 nm in the presence of salicylic acid as a photosensitizer, six product peaks appeared in an HPLC chromatogram in addition to small amounts of thymidine dimers. The six products were identified as three pairs of diastereomers of 5-(2-deoxy-2-l-ascorbyl)-5,6-dihydrothymidine, 5-(2-l-ascorbyl)-5,6-dihydrothymidine, and 5,6-dihydrothymidine. These results suggest that novel DNA damage may be generated by ascorbic acid with salicylic acid induced by sunlight.

Identifiants

DOI: 10.1016/j.bmc.2019.115046 PMID: 31422010
pubmed: 31422010
pii: S0968-0896(19)31142-3
doi: 10.1016/j.bmc.2019.115046
pii:
doi:

Substances chimiques

Photosensitizing Agents 0
Pyrimidine Dimers 0
Salicylic Acid O414PZ4LPZ
Ascorbic Acid PQ6CK8PD0R
Thymidine VC2W18DGKR

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

115046

Informations de copyright

Copyright © 2019 Elsevier Ltd. All rights reserved.

Auteurs

Toshinori Suzuki (T)

School of Pharmacy, Shujitsu University, 1-6-1 Nishigawara, Okayama 703-8516, Japan. Electronic address: tsuzuki@shujitsu.ac.jp.

Yuki Kishida (Y)

School of Pharmacy, Shujitsu University, 1-6-1 Nishigawara, Okayama 703-8516, Japan.

Articles similaires

Necroptosis as a consequence of photodynamic therapy in tumor cells.

Álvaro Carneiro de Souza, André Luiz Mencalha, Adenilson de Souza da Fonseca et al.
1.00
Photochemotherapy Humans Necroptosis Neoplasms Photosensitizing Agents

Self-assembled aldehyde dehydrogenase-activatable nano-prodrug for cancer stem cell-enriched tumor detection and treatment.

Bowen Li, Jianwu Tian, Fu Zhang et al.
1.00
Neoplastic Stem Cells Animals Humans Aldehyde Dehydrogenase Tretinoin

Combined use of 5-ALA-induced protoporphyrin IX and chlorin e6 for fluorescence diagnostics and photodynamic therapy of skin tumors.

Kanamat Efendiev, Polina Alekseeva, Alexey Skobeltsin et al.
1.00
Protoporphyrins Photochemotherapy Humans Aminolevulinic Acid Chlorophyllides

Synthesis and characterization of new organometallic lanthanides metal complexes for photodynamic therapy.

H A Fetouh, E H El-Mossalamy, J M El Desouky et al.
1.00
Photochemotherapy Lanthanoid Series Elements Humans Coordination Complexes Schiff Bases

Classifications MeSH

questionsmedicales.fr › Glucides › Oses acides › Acide ascorbique › Reaction of thymidine and ascorbic acid...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Cinétique › Reaction of thymidine and ascorbic acid...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Radiosensibilisants › Photosensibilisants › Reaction of thymidine and ascorbic acid...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Nucléotides › Nucléotides pyrimidiques › Dimères de pyrimidine › Reaction of thymidine and ascorbic acid...
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Hydrocarbures cycliques › Hydrocarbures aromatiques › Dérivés du benzène › Phénols › Hydroxybenzoates › Salicylates › Acide salicylique › Reaction of thymidine and ascorbic acid...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Nucléosides › Nucléosides pyrimidiques › Thymidine › Reaction of thymidine and ascorbic acid...
questionsmedicales.fr › Environnement et santé publique › Environnement › Concepts météorologiques › Atmosphère › Temps (météorologie) › Lumière du soleil › Rayons ultraviolets › Reaction of thymidine and ascorbic acid...