fMRI and electroencephalographic evaluation of sleep deprivation in epilepsy patients: An observational study.
EEG
Epilepsy
Sleep deprivation
fMRI
Journal
Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
ISSN: 1532-2653
Titre abrégé: J Clin Neurosci
Pays: Scotland
ID NLM: 9433352
Informations de publication
Date de publication:
Nov 2019
Nov 2019
Historique:
received:
15
05
2019
accepted:
04
08
2019
pubmed:
21
8
2019
medline:
14
1
2020
entrez:
21
8
2019
Statut:
ppublish
Résumé
Sleep deprivation (SD) is considered an important activation test to facilitate the visualization of electroencephalogram (EEG) epileptic abnormalities, in order to perform a correct diagnosis. The aim of this study was to evaluate the local functional activity in healthy controls (HC) subjects and left mesial temporal lobe epilepsy-hippocampal sclerosis patients, after a SD, by using functional Magnetic Resonance Imaging (fMRI) and EEG. We enrolled 22 healthy controls and 34 patients with a diagnosis of left mesial temporal lobe epilepsy-hippocampal sclerosis. Each participant underwent two examinations separately: an fMRI study using 3 T MRI to detect spontaneous activity during the RS-fMRI and an EEG. The SD-EEG results showed the presence of epileptiform discharges predominantly in left fronto-centro-temporal areas. fMRI findings if compared to HC showed an increase of functional activity in some areas. We showed that SD-EEG study confirmed a high specificity to assess a specific diagnosis. Therefore, the decrease of activity observed in DMN could be explain by a different amount of sleep/awake time during fMRI recording in the two groups or the interictal activity during fMRI acquisition. Our study highlighted alterated functional activity in SD cortical areas of epileptic patients if compared to HC.
Sections du résumé
BACKGROUND
BACKGROUND
Sleep deprivation (SD) is considered an important activation test to facilitate the visualization of electroencephalogram (EEG) epileptic abnormalities, in order to perform a correct diagnosis.
OBJECTIVE
OBJECTIVE
The aim of this study was to evaluate the local functional activity in healthy controls (HC) subjects and left mesial temporal lobe epilepsy-hippocampal sclerosis patients, after a SD, by using functional Magnetic Resonance Imaging (fMRI) and EEG.
MATERIALS AND METHODS
METHODS
We enrolled 22 healthy controls and 34 patients with a diagnosis of left mesial temporal lobe epilepsy-hippocampal sclerosis. Each participant underwent two examinations separately: an fMRI study using 3 T MRI to detect spontaneous activity during the RS-fMRI and an EEG.
RESULTS
RESULTS
The SD-EEG results showed the presence of epileptiform discharges predominantly in left fronto-centro-temporal areas. fMRI findings if compared to HC showed an increase of functional activity in some areas.
DISCUSSION
CONCLUSIONS
We showed that SD-EEG study confirmed a high specificity to assess a specific diagnosis. Therefore, the decrease of activity observed in DMN could be explain by a different amount of sleep/awake time during fMRI recording in the two groups or the interictal activity during fMRI acquisition. Our study highlighted alterated functional activity in SD cortical areas of epileptic patients if compared to HC.
Identifiants
pubmed: 31427236
pii: S0967-5868(19)30984-1
doi: 10.1016/j.jocn.2019.08.015
pii:
doi:
Types de publication
Journal Article
Observational Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
120-123Informations de copyright
Copyright © 2019 Elsevier Ltd. All rights reserved.