A quantitative systems pharmacology model of colonic motility with applications in drug development.
5-HT4 receptor
Bowel dysfunction
Colon
Constipation
Enteric nervous system
GI motility
Quantitative systems pharmacology
Journal
Journal of pharmacokinetics and pharmacodynamics
ISSN: 1573-8744
Titre abrégé: J Pharmacokinet Pharmacodyn
Pays: United States
ID NLM: 101096520
Informations de publication
Date de publication:
Oct 2019
Oct 2019
Historique:
received:
02
01
2019
accepted:
09
08
2019
pubmed:
23
8
2019
medline:
19
5
2020
entrez:
22
8
2019
Statut:
ppublish
Résumé
We developed a mathematical model of colon physiology driven by serotonin signaling in the enteric nervous system. No such models are currently available to assist drug discovery and development for GI motility disorders. Model parameterization was informed by published preclinical and clinical data. Our simulations provide clinically relevant readouts of bowel movement frequency and stool consistency. The model recapitulates healthy and slow transit constipation phenotypes, and the effect of a 5-HT
Identifiants
pubmed: 31432345
doi: 10.1007/s10928-019-09651-6
pii: 10.1007/s10928-019-09651-6
doi:
Substances chimiques
Serotonin Receptor Agonists
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
485-498Références
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