Travel Surveillance and Genomics Uncover a Hidden Zika Outbreak during the Waning Epidemic.
Zika epidemic
Zika virus
clinical sequencing
genomic epidemiology
infectious disease genomics
phylogenetics
travel surveillance
virus sequencing
Journal
Cell
ISSN: 1097-4172
Titre abrégé: Cell
Pays: United States
ID NLM: 0413066
Informations de publication
Date de publication:
22 08 2019
22 08 2019
Historique:
received:
19
12
2018
revised:
15
04
2019
accepted:
12
07
2019
entrez:
24
8
2019
pubmed:
24
8
2019
medline:
12
5
2020
Statut:
ppublish
Résumé
The Zika epidemic in the Americas has challenged surveillance and control. As the epidemic appears to be waning, it is unclear whether transmission is still ongoing, which is exacerbated by discrepancies in reporting. To uncover locations with lingering outbreaks, we investigated travel-associated Zika cases to identify transmission not captured by reporting. We uncovered an unreported outbreak in Cuba during 2017, a year after peak transmission in neighboring islands. By sequencing Zika virus, we show that the establishment of the virus was delayed by a year and that the ensuing outbreak was sparked by long-lived lineages of Zika virus from other Caribbean islands. Our data suggest that, although mosquito control in Cuba may initially have been effective at mitigating Zika virus transmission, such measures need to be maintained to be effective. Our study highlights how Zika virus may still be "silently" spreading and provides a framework for understanding outbreak dynamics. VIDEO ABSTRACT.
Identifiants
pubmed: 31442400
pii: S0092-8674(19)30783-4
doi: 10.1016/j.cell.2019.07.018
pmc: PMC6716374
mid: NIHMS1534972
pii:
doi:
Substances chimiques
RNA, Viral
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
1057-1071.e11Subventions
Organisme : NCEZID CDC HHS
ID : U50 CK000189
Pays : United States
Organisme : NICHD NIH HHS
ID : T32 HD040128
Pays : United States
Organisme : NIAID NIH HHS
ID : HHSN272201400048C
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI099210
Pays : United States
Organisme : NIAID NIH HHS
ID : U19 AI135995
Pays : United States
Organisme : NIAID NIH HHS
ID : R21 AI137690
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR002550
Pays : United States
Informations de copyright
Copyright © 2019 Elsevier Inc. All rights reserved.
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