The Bone Marrow Protects and Optimizes Immunological Memory during Dietary Restriction.

Animals Bone Marrow / immunology CD8-Positive T-Lymphocytes / cytology Caloric Restriction / veterinary Cell Line, Tumor Chemokine CXCL12 / metabolism Diet, Reducing / veterinary Energy Metabolism Gene Expression Regulation Glucocorticoids Immunologic Memory Melanoma, Experimental / mortality Mice Mice, Inbred C57BL Proto-Oncogene Proteins c-akt / metabolism Receptors, CXCR4 / metabolism Survival Rate T-Lymphocytes / immunology TOR Serine-Threonine Kinases / metabolism

Journal

Cell
ISSN: 1097-4172
Titre abrégé: Cell
Pays: United States
ID NLM: 0413066

Informations de publication

Date de publication:
22 08 2019
Historique:
received: 18 12 2018
revised: 28 05 2019
accepted: 29 07 2019
entrez: 24 8 2019
pubmed: 24 8 2019
medline: 12 5 2020
Statut: ppublish

Résumé

Mammals evolved in the face of fluctuating food availability. How the immune system adapts to transient nutritional stress remains poorly understood. Here, we show that memory T cells collapsed in secondary lymphoid organs in the context of dietary restriction (DR) but dramatically accumulated within the bone marrow (BM), where they adopted a state associated with energy conservation. This response was coordinated by glucocorticoids and associated with a profound remodeling of the BM compartment, which included an increase in T cell homing factors, erythropoiesis, and adipogenesis. Adipocytes, as well as CXCR4-CXCL12 and S1P-S1P

Identifiants

DOI: 10.1016/j.cell.2019.07.049 PMID: 31442402 PMC: PMC6818271
pubmed: 31442402
pii: S0092-8674(19)30849-9
doi: 10.1016/j.cell.2019.07.049
pmc: PMC6818271
mid: NIHMS1055644
pii:
doi:

Substances chimiques

Chemokine CXCL12 0
Glucocorticoids 0
Receptors, CXCR4 0
mTOR protein, mouse EC 2.7.1.1
Proto-Oncogene Proteins c-akt EC 2.7.11.1
TOR Serine-Threonine Kinases EC 2.7.11.1

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, N.I.H., Intramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1088-1101.e15

Subventions

Organisme : NIAID NIH HHS
ID : R01 AI123308
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI085166
Pays : United States
Organisme : Intramural NIH HHS
ID : ZIA AI001133
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA202025
Pays : United States
Organisme : Intramural NIH HHS
ID : ZIA AI001132
Pays : United States
Organisme : Intramural NIH HHS
ID : ZIA NS003111-10
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA014236
Pays : United States
Organisme : NIAID NIH HHS
ID : T32 AI100853
Pays : United States

Commentaires et corrections

Type : CommentIn
Type : CommentIn
Type : CommentIn

Informations de copyright

Copyright © 2019 Elsevier Inc. All rights reserved.

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Auteurs

Nicholas Collins (N)

Metaorganism Immunity Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

Seong-Ji Han (SJ)

Metaorganism Immunity Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

Michel Enamorado (M)

Metaorganism Immunity Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

Verena M Link (VM)

Metaorganism Immunity Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

Bonnie Huang (B)

Cell Signaling Section, Laboratory of Immune System Biology, National Institutes of Health, Bethesda, MD 20892, USA.

E Ashley Moseman (EA)

Viral Immunology and Intravital Imaging Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.

Rigel J Kishton (RJ)

Surgery Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20814, USA.

John P Shannon (JP)

Viral Immunity and Pathogenesis Unit, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

Dhaval Dixit (D)

Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA.

Susan R Schwab (SR)

Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA.

Heather D Hickman (HD)

Viral Immunity and Pathogenesis Unit, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

Nicholas P Restifo (NP)

Surgery Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20814, USA.

Dorian B McGavern (DB)

Viral Immunology and Intravital Imaging Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.

Pamela L Schwartzberg (PL)

Cell Signaling Section, Laboratory of Immune System Biology, National Institutes of Health, Bethesda, MD 20892, USA.

Yasmine Belkaid (Y)

Metaorganism Immunity Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address: ybelkaid@niaid.nih.gov.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › The Bone Marrow Protects and Optimizes...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Moelle osseuse › The Bone Marrow Protects and Optimizes...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Lymphocytes T CD8+ › The Bone Marrow Protects and Optimizes...
questionsmedicales.fr › Phénomènes physiologiques › Alimentation et nutrition › Phénomènes physiologiques nutritionnels › Régime alimentaire › Ration calorique › Restriction calorique › The Bone Marrow Protects and Optimizes...
questionsmedicales.fr › Cellules › Cellules cultivées › Cellules cancéreuses en culture › Lignée cellulaire tumorale › The Bone Marrow Protects and Optimizes...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Chimiokines › Chimiokines CXC › Chimiokine CXCL12 › The Bone Marrow Protects and Optimizes...
questionsmedicales.fr › Phénomènes physiologiques › Alimentation et nutrition › Phénomènes physiologiques nutritionnels › Régime alimentaire › Régime amaigrissant › The Bone Marrow Protects and Optimizes...
questionsmedicales.fr › Métabolisme › Métabolisme énergétique › The Bone Marrow Protects and Optimizes...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › The Bone Marrow Protects and Optimizes...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Hormones, substituts d'hormones et antagonistes d'hormones › Hormones › Glucocorticoïdes › The Bone Marrow Protects and Optimizes...
questionsmedicales.fr › Phénomènes du système immunitaire › Immunité › Immunité acquise › Mémoire immunologique › The Bone Marrow Protects and Optimizes...
questionsmedicales.fr › Techniques d'investigation › Modèles animaux › Tumeurs expérimentales › Mélanome expérimental › The Bone Marrow Protects and Optimizes...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › The Bone Marrow Protects and Optimizes...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › The Bone Marrow Protects and Optimizes...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines tumorales › Protéines oncogènes › Protéines proto-oncogènes › Protéines proto-oncogènes c-akt › The Bone Marrow Protects and Optimizes...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs viraux › Récepteur VIH › Récepteurs CXCR4 › The Bone Marrow Protects and Optimizes...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Collecte de données › Registre civil › Mortalité › Taux de survie › The Bone Marrow Protects and Optimizes...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › The Bone Marrow Protects and Optimizes...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protein-Serine-Threonine Kinases › Sérine-thréonine kinases TOR › The Bone Marrow Protects and Optimizes...