Deep Sequencing Reveals Central Nervous System Compartmentalization in Multiple Transmitted/Founder Virus Acute HIV-1 Infection.

Adult Female Genes, env / genetics Genes, pol / genetics HIV Infections / blood HIV-1 / genetics High-Throughput Nucleotide Sequencing Humans Male RNA, Viral / blood Sequence Analysis, RNA Virus Replication Young Adult
HIV-1 acute HIV-1 infection (AHI) central nervous system (CNS) cerebrospinal fluid (CSF) compartmentalization multiple infections next-generation sequencing (NGS) single-genome amplification (SGA) transmitted/founder (T/F) virus

Journal

Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052

Informations de publication

Date de publication:
15 08 2019
Historique:
received: 19 07 2019
revised: 10 08 2019
accepted: 11 08 2019
entrez: 25 8 2019
pubmed: 25 8 2019
medline: 9 4 2020
Statut: epublish

Résumé

HIV-1 disseminates to a broad range of tissue compartments during acute HIV-1 infection (AHI). The central nervous system (CNS) can serve as an early and persistent site of viral replication, which poses a potential challenge for HIV-1 remission strategies that target the HIV reservoir. CNS compartmentalization is a key feature of HIV-1 neuropathogenesis. Thus far, the timing of how early CNS compartmentalization develops after infection is unknown. We examined whether HIV-1 transmitted/founder (T/F) viruses differ between CNS and blood during AHI using single-genome sequencing of envelope gene and further examined subregions in

Identifiants

DOI: 10.3390/cells8080902 PMID: 31443253 PMC: PMC6721674
pubmed: 31443253
pii: cells8080902
doi: 10.3390/cells8080902
pmc: PMC6721674
pii:
doi:

Substances chimiques

RNA, Viral 0

Banques de données

ClinicalTrials.gov
['NCT00796146']

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, U.S. Gov't, Non-P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : NIA NIH HHS
ID : T32 AG023481
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001863
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS084911
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH095613
Pays : United States

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Auteurs

Sodsai Tovanabutra (S)

U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA. stovanabutra@hivresearch.org.
The Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20817, USA. stovanabutra@hivresearch.org.

Rujipas Sirijatuphat (R)

U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.
The Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20817, USA.
Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand.

Phuc T Pham (PT)

U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.
The Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20817, USA.

Lydia Bonar (L)

U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.
The Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20817, USA.

Elizabeth A Harbolick (EA)

U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.
The Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20817, USA.

Meera Bose (M)

U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.
The Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20817, USA.

Hongshuo Song (H)

U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.
The Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20817, USA.

David Chang (D)

U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.
The Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20817, USA.

Celina Oropeza (C)

U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.
The Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20817, USA.

Anne Marie O'Sullivan (AM)

U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.
The Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20817, USA.

Joyce Balinang (J)

U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.
The Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20817, USA.

Eugene Kroon (E)

SEARCH, Thai Red Cross AIDS Research Centre, Bangkok 10330, Thailand.

Donn J Colby (DJ)

SEARCH, Thai Red Cross AIDS Research Centre, Bangkok 10330, Thailand.

Carlo Sacdalan (C)

SEARCH, Thai Red Cross AIDS Research Centre, Bangkok 10330, Thailand.

Joanna Hellmuth (J)

Memory and Aging Center, Department of Neurology, University of California, San Francisco, CA 94158, USA.

Phillip Chan (P)

SEARCH, Thai Red Cross AIDS Research Centre, Bangkok 10330, Thailand.
ORCID: 0000-0002-4071-4409

Peeriya Prueksakaew (P)

SEARCH, Thai Red Cross AIDS Research Centre, Bangkok 10330, Thailand.

Suteeraporn Pinyakorn (S)

U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.
The Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20817, USA.

Linda L Jagodzinski (LL)

U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.

Duanghathai Sutthichom (D)

SEARCH, Thai Red Cross AIDS Research Centre, Bangkok 10330, Thailand.

Suwanna Pattamaswin (S)

SEARCH, Thai Red Cross AIDS Research Centre, Bangkok 10330, Thailand.

Mark de Souza (M)

The Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20817, USA.
SEARCH, Thai Red Cross AIDS Research Centre, Bangkok 10330, Thailand.

Robert A Gramzinski (RA)

U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.

Jerome H Kim (JH)

U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.
International Vaccine Institute, Seoul 08826, Korea.

Nelson L Michael (NL)

U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.
The Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20817, USA.

Merlin L Robb (ML)

U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.
The Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20817, USA.
ORCID: 0000-0003-3949-9649

Nittaya Phanuphak (N)

SEARCH, Thai Red Cross AIDS Research Centre, Bangkok 10330, Thailand.

Jintanat Ananworanich (J)

U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.
The Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20817, USA.
SEARCH, Thai Red Cross AIDS Research Centre, Bangkok 10330, Thailand.
Academic Medical Center, Department of Global Health, University of Amsterdam, 1105AZ Amsterdam, The Netherlands.

Victor Valcour (V)

Memory and Aging Center, Department of Neurology, University of California, San Francisco, CA 94158, USA.

Gustavo H Kijak (GH)

U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.
The Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20817, USA.

Eric Sanders-Buell (E)

U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.
The Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20817, USA.

Serena Spudich (S)

Department of Neurology, Yale University; New Haven, CT 06510, USA.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Deep Sequencing Reveals Central Nervous System...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Génome microbien › Génome viral › Gènes viraux › Gènes env › Deep Sequencing Reveals Central Nervous System...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Génome microbien › Génome viral › Gènes viraux › Gènes pol › Deep Sequencing Reveals Central Nervous System...
questionsmedicales.fr › Maladies du système immunitaire › Déficits immunitaires › Infections à VIH › Deep Sequencing Reveals Central Nervous System...
questionsmedicales.fr › Virus › Virus à ARN › Retroviridae › Lentivirus › Lentivirus des primates › VIH (Virus de l'Immunodéficience Humaine) › VIH-1 (Virus de l'Immunodéficience Humaine de type 1) › Deep Sequencing Reveals Central Nervous System...
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Analyse de séquence › Séquençage nucléotidique à haut débit › Deep Sequencing Reveals Central Nervous System...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Deep Sequencing Reveals Central Nervous System...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ARN › ARN viral › Deep Sequencing Reveals Central Nervous System...
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Analyse de séquence › Analyse de séquence d'ARN › Deep Sequencing Reveals Central Nervous System...
questionsmedicales.fr › Phénomènes microbiologiques › Phénomènes physiologiques viraux › Réplication virale › Deep Sequencing Reveals Central Nervous System...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Jeune adulte › Deep Sequencing Reveals Central Nervous System...