NMR Studies of G-Quadruplex Structures and G-Quadruplex-Interactive Compounds.
G-quadruplex structures
G-quadruplex-interactive compounds
NMR spectroscopy
Journal
Methods in molecular biology (Clifton, N.J.)
ISSN: 1940-6029
Titre abrégé: Methods Mol Biol
Pays: United States
ID NLM: 9214969
Informations de publication
Date de publication:
2019
2019
Historique:
entrez:
25
8
2019
pubmed:
25
8
2019
medline:
9
4
2020
Statut:
ppublish
Résumé
G-quadruplexes are noncanonical, four-stranded nucleic acid secondary structures formed in sequences containing consecutive runs of guanines. These G-quadruplex structures have been found to form in nucleic acid regions of biological significance, including human telomeres, gene promoters, and untranslated regions of mRNA. Thus, they are considered attractive therapeutic targets. Nuclear magnetic resonance (NMR) spectroscopy is a powerful method for understanding the structures of G-quadruplexes and their interactions with small molecules under physiologically relevant conditions. Here, we present the NMR methodology used in our research group for the study of DNA G-quadruplex structures in physiologically relevant solution and their ligand interactions.
Identifiants
pubmed: 31444749
doi: 10.1007/978-1-4939-9666-7_9
pmc: PMC7263470
mid: NIHMS1591358
doi:
Substances chimiques
RNA, Messenger
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
157-176Subventions
Organisme : NCI NIH HHS
ID : P30 CA023168
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA122952
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA177585
Pays : United States
Références
Nucleic Acids Res. 2006 May 19;34(9):2723-35
pubmed: 16714449
J Biomol NMR. 2000 Feb;16(2):175-8
pubmed: 10723997
J Am Chem Soc. 2001 Feb 14;123(6):1262-3
pubmed: 11456694
Biochemistry. 2005 Feb 15;44(6):2048-58
pubmed: 15697230
J Biol Chem. 2004 Oct 29;279(44):46096-103
pubmed: 15317822
Nature. 2002 Jun 20;417(6891):876-80
pubmed: 12050675
J Med Chem. 1997 Jul 4;40(14):2113-6
pubmed: 9216827
Nucleic Acids Res. 2007;35(7):2440-50
pubmed: 17395643
Sci China Chem. 2014 Dec;57(12):1605-1614
pubmed: 27182219
Mol Cancer Ther. 2018 Jun;17(6):1177-1186
pubmed: 29626127
Future Med Chem. 2010 Apr;2(4):619-46
pubmed: 20563318
Structure. 1993 Dec 15;1(4):263-82
pubmed: 8081740
Nucleic Acids Res. 2012 Aug;40(14):6946-56
pubmed: 22532609
Nat Rev Drug Discov. 2011 Apr;10(4):261-75
pubmed: 21455236
J Biomol NMR. 1995 Jun;5(4):333-8
pubmed: 7647551
Nature. 1990 Mar 29;344(6265):410-4
pubmed: 2320109
Bioorg Med Chem. 2018 Jul 15;26(11):2958-2964
pubmed: 29724653
J Am Chem Soc. 2006 Aug 2;128(30):9963-70
pubmed: 16866556
Nat Rev Cancer. 2009 Dec;9(12):849-61
pubmed: 19907434
Nat Rev Drug Discov. 2002 May;1(5):383-93
pubmed: 12120414
J Med Chem. 2016 Jul 14;59(13):5987-6011
pubmed: 26840940
Biochimie. 2008 Aug;90(8):1149-71
pubmed: 18355457