A survey of known immune epitopes in the enteroviruses strains associated with acute flaccid myelitis.
Antigens, Viral
/ genetics
B-Lymphocytes
/ immunology
Central Nervous System Viral Diseases
/ immunology
Computational Biology
Coxsackievirus Infections
/ immunology
Cross Reactions
Enterovirus A, Human
/ physiology
Enterovirus D, Human
/ physiology
Epitope Mapping
Host-Pathogen Interactions
Humans
Immunity, Cellular
Immunodominant Epitopes
/ genetics
Myelitis
/ immunology
Neuromuscular Diseases
/ immunology
Receptors, Antigen
/ metabolism
Sequence Analysis, RNA
Species Specificity
T-Lymphocytes
/ immunology
AFM
B cells
Enteroviruses
Epitopes
T cells
Journal
Human immunology
ISSN: 1879-1166
Titre abrégé: Hum Immunol
Pays: United States
ID NLM: 8010936
Informations de publication
Date de publication:
Nov 2019
Nov 2019
Historique:
received:
12
06
2019
revised:
08
08
2019
accepted:
16
08
2019
pubmed:
28
8
2019
medline:
4
4
2020
entrez:
28
8
2019
Statut:
ppublish
Résumé
Enteroviruses are potentially linked to the emergence of Acute Flaccid Myelitis (AFM), a rare but very serious condition that affects the nervous system. AFM has been associated with coxsackievirus A16, enterovirus A71 (EVA71) and enterovirus D68 (EVD68). Little is known about host-pathogen interactions for these viruses, and whether immune responses may have a protective or immunopathological role in disease presentations. Towards addressing this issue, we used the Immune Epitope Database to assess the known inventory of B and T cell epitopes from enteroviruses, focusing on data related to human hosts. The extent of conservation in areas that are targets of B and T cell immune responses were examined. This analysis sheds light on regions of the enterovirus polypeptide that can be probed to induce a specific or cross-reactive B or T cell the immune response to enteroviruses, with a particular focus on coxsackievirus A16, EVA71 and EVD68. In addition, these analyses reveal the current gap-of-knowledge in the T and B cell immune responses that future studies should aim to address.
Identifiants
pubmed: 31451291
pii: S0198-8859(19)30608-1
doi: 10.1016/j.humimm.2019.08.004
pmc: PMC6876747
mid: NIHMS1538203
pii:
doi:
Substances chimiques
Antigens, Viral
0
Immunodominant Epitopes
0
Receptors, Antigen
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
923-929Subventions
Organisme : NIAID NIH HHS
ID : 75N93019C00001
Pays : United States
Informations de copyright
Copyright © 2019 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.
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