Marchiafava-Bignami disease with haemophagocytic lymphohistiocytosis as a postoperative complication of cardiac surgery.
Autopsy
/ methods
Brain
/ diagnostic imaging
Coronary Artery Bypass, Off-Pump
/ adverse effects
Coronary Artery Disease
/ surgery
Corpus Callosum
/ diagnostic imaging
Fatal Outcome
Humans
Lymphohistiocytosis, Hemophagocytic
/ etiology
Magnetic Resonance Imaging
/ methods
Male
Marchiafava-Bignami Disease
/ diagnosis
Middle Aged
Postoperative Complications
/ diagnosis
cardiothoracic surgery
neurology
Journal
BMJ case reports
ISSN: 1757-790X
Titre abrégé: BMJ Case Rep
Pays: England
ID NLM: 101526291
Informations de publication
Date de publication:
26 Aug 2019
26 Aug 2019
Historique:
entrez:
28
8
2019
pubmed:
28
8
2019
medline:
7
2
2020
Statut:
epublish
Résumé
Marchiafava-Bignami disease (MBD) is a rare complication of chronic alcoholism; however, MBD in a non-alcoholic diabetic patient has rarely been reported. The aetiology or pathophysiology of MBD is still unknown. A 50-year-old man with a history of untreated diabetes mellitus underwent on-pump beating coronary artery bypass graft surgery (CABG) surgery for three-vessel and left main coronary disease. 3 days after the surgery, he developed a fever over 40°C and entered a coma state. MRI revealed multiple lesions, including in the corpus callosum, globus pallidus, brain stem and upper cervical spinal cord, which suggested MBD. The patient did not respond to thiamine therapy, but partly responded to steroid therapy. He ultimately died of respiratory failure. The autopsy revealed MBD and haemophagocytic lymphohistiocytosis. It is rare, but systemic inflammatory response syndrome induced by on-pump beating CABG could develop these complication.
Identifiants
pubmed: 31451466
pii: 12/8/e230368
doi: 10.1136/bcr-2019-230368
pmc: PMC6720698
pii:
doi:
Types de publication
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© BMJ Publishing Group Limited 2019. No commercial re-use. See rights and permissions. Published by BMJ.
Déclaration de conflit d'intérêts
Competing interests: None declared.
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