Allosteric modulation of β-cell M
Acetylcholine
/ metabolism
Adult
Allosteric Regulation
/ drug effects
Animals
Blood Glucose
/ analysis
Cell Line, Tumor
Diabetes Mellitus, Type 2
/ blood
Disease Models, Animal
Female
Glucose Intolerance
/ blood
Humans
Hypoglycemic Agents
/ pharmacology
Insulin Secretion
/ drug effects
Islets of Langerhans
/ drug effects
Male
Mice
Mice, Obese
Mice, Transgenic
Middle Aged
Muscarinic Agonists
/ pharmacology
Obesity
/ blood
Primary Cell Culture
Proof of Concept Study
Receptor, Muscarinic M3
/ drug effects
Young Adult
G protein-coupled receptor
acetylcholine
allosteric modulator
insulin release
muscarinic receptor
Journal
Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876
Informations de publication
Date de publication:
10 09 2019
10 09 2019
Historique:
pubmed:
28
8
2019
medline:
9
4
2020
entrez:
28
8
2019
Statut:
ppublish
Résumé
Given the global epidemic in type 2 diabetes, novel antidiabetic drugs with increased efficacy and reduced side effects are urgently needed. Previous work has shown that M
Identifiants
pubmed: 31451647
pii: 1904943116
doi: 10.1073/pnas.1904943116
pmc: PMC6744902
doi:
Substances chimiques
Blood Glucose
0
Hypoglycemic Agents
0
Muscarinic Agonists
0
Receptor, Muscarinic M3
0
Acetylcholine
N9YNS0M02X
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, N.I.H., Intramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
18684-18690Subventions
Organisme : Intramural NIH HHS
ID : ZIA DE000738
Pays : United States
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
Références
Am J Physiol. 1999 Jul;277(1):E93-102
pubmed: 10409132
Diabetologia. 2000 Apr;43(4):393-410
pubmed: 10819232
Proc Natl Acad Sci U S A. 2000 Aug 15;97(17):9579-84
pubmed: 10944224
Nature. 2001 Mar 8;410(6825):207-12
pubmed: 11242080
Endocr Rev. 2001 Oct;22(5):565-604
pubmed: 11588141
Development. 2002 May;129(10):2447-57
pubmed: 11973276
Biochem Biophys Res Commun. 2004 Mar 19;315(4):872-6
pubmed: 14985093
J Physiol. 2004 Jul 15;558(Pt 2):561-75
pubmed: 15146045
Diabetes. 2004 Jul;53(7):1714-20
pubmed: 15220195
Cell Metab. 2006 Jun;3(6):449-61
pubmed: 16753580
Nat Rev Drug Discov. 2007 Sep;6(9):721-33
pubmed: 17762886
Mol Pharmacol. 2009 Mar;75(3):577-88
pubmed: 19047481
Trends Pharmacol Sci. 2009 Mar;30(3):148-55
pubmed: 19201489
Nat Rev Drug Discov. 2009 May;8(5):369-85
pubmed: 19365392
Cell Metab. 2009 Oct;10(4):285-95
pubmed: 19808021
Bioorg Med Chem Lett. 2010 Jan 15;20(2):558-62
pubmed: 20004578
Proc Natl Acad Sci U S A. 2010 Apr 27;107(17):7999-8004
pubmed: 20385802
Trends Endocrinol Metab. 2011 Feb;22(2):74-80
pubmed: 21106385
Pharmacol Ther. 2013 Sep;139(3):359-91
pubmed: 23694765
Nature. 2013 Nov 14;503(7475):295-9
pubmed: 24121438
Nature. 2013 Dec 5;504(7478):101-6
pubmed: 24256733
Curr Opin Cell Biol. 2014 Apr;27:94-101
pubmed: 24680434
J Diabetes Investig. 2010 Aug 2;1(4):137-42
pubmed: 24843422
Nat Rev Drug Discov. 2014 Jul;13(7):549-60
pubmed: 24903776
Diabetes. 1989 Nov;38(11):1433-8
pubmed: 2576006
Nature. 2016 Mar 17;531(7594):335-40
pubmed: 26958838
Cell Metab. 2016 Oct 11;24(4):608-615
pubmed: 27667665
Neuropharmacology. 2018 Jul 1;136(Pt C):427-437
pubmed: 28935216
Cell Metab. 2018 Apr 3;27(4):740-756
pubmed: 29617641
Nature. 2018 Jul;559(7712):45-53
pubmed: 29973731
J Diabetes Investig. 2019 Mar;10(2):196-201
pubmed: 30099845
J Gen Physiol. 2018 Oct 1;150(10):1360-1372
pubmed: 30190312
Nat Methods. 2019 Feb;16(2):151-162
pubmed: 30664776