Aging promotes reorganization of the CD4 T cell landscape toward extreme regulatory and effector phenotypes.
Journal
Science advances
ISSN: 2375-2548
Titre abrégé: Sci Adv
Pays: United States
ID NLM: 101653440
Informations de publication
Date de publication:
08 2019
08 2019
Historique:
received:
30
01
2019
accepted:
12
07
2019
entrez:
29
8
2019
pubmed:
29
8
2019
medline:
8
5
2020
Statut:
epublish
Résumé
Age-associated changes in CD4 T-cell functionality have been linked to chronic inflammation and decreased immunity. However, a detailed characterization of CD4 T cell phenotypes that could explain these dysregulated functional properties is lacking. We used single-cell RNA sequencing and multidimensional protein analyses to profile thousands of CD4 T cells obtained from young and old mice. We found that the landscape of CD4 T cell subsets differs markedly between young and old mice, such that three cell subsets-exhausted, cytotoxic, and activated regulatory T cells (aT
Identifiants
pubmed: 31457092
doi: 10.1126/sciadv.aaw8330
pii: aaw8330
pmc: PMC6703865
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
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