Anti-HIV and Anti-Hepatitis C Virus Drugs Inhibit P-Glycoprotein Efflux Activity in Caco-2 Cells and Precision-Cut Rat and Human Intestinal Slices.
ATP Binding Cassette Transporter, Subfamily B, Member 1
/ antagonists & inhibitors
Aged
Animals
Anti-HIV Agents
/ pharmacology
Antiviral Agents
/ pharmacology
Atazanavir Sulfate
/ pharmacology
Benzimidazoles
/ pharmacology
Caco-2 Cells
/ drug effects
Carbamates
Drug Interactions
Female
Fluorenes
/ pharmacology
HIV Infections
/ complications
Hepatitis C
/ complications
Humans
Imidazoles
/ pharmacology
Intestines
/ drug effects
Lopinavir
/ pharmacology
Male
Maraviroc
/ pharmacology
Middle Aged
Pyrrolidines
Rats
Rats, Wistar
Ritonavir
/ pharmacology
Saquinavir
/ pharmacology
Valine
/ analogs & derivatives
Zidovudine
/ pharmacology
Caco-2 cells
P-glycoprotein
antiviral drugs
drug-drug interactions
intestinal absorption
precision-cut intestinal slices
rhodamine 123
Journal
Antimicrobial agents and chemotherapy
ISSN: 1098-6596
Titre abrégé: Antimicrob Agents Chemother
Pays: United States
ID NLM: 0315061
Informations de publication
Date de publication:
11 2019
11 2019
Historique:
received:
03
05
2019
accepted:
30
08
2019
pubmed:
5
9
2019
medline:
20
8
2020
entrez:
5
9
2019
Statut:
epublish
Résumé
P-glycoprotein (ABCB1), an ATP-binding-cassette efflux transporter, limits intestinal absorption of its substrates and is a common site of drug-drug interactions (DDIs). ABCB1 has been suggested to interact with many antivirals used to treat HIV and/or chronic hepatitis C virus (HCV) infections. Using bidirectional transport experiments in Caco-2 cells and a recently established
Identifiants
pubmed: 31481446
pii: AAC.00910-19
doi: 10.1128/AAC.00910-19
pmc: PMC6811448
pii:
doi:
Substances chimiques
ATP Binding Cassette Transporter, Subfamily B, Member 1
0
Anti-HIV Agents
0
Antiviral Agents
0
Benzimidazoles
0
Carbamates
0
Fluorenes
0
Imidazoles
0
Pyrrolidines
0
ledipasvir
013TE6E4WV
Lopinavir
2494G1JF75
Zidovudine
4B9XT59T7S
Atazanavir Sulfate
4MT4VIE29P
Valine
HG18B9YRS7
Saquinavir
L3JE09KZ2F
daclatasvir
LI2427F9CI
Maraviroc
MD6P741W8A
Ritonavir
O3J8G9O825
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
Copyright © 2019 American Society for Microbiology.
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