Alleles Animals Brain / pathology Chemotaxis Encephalitis / virology Female Humans Infections / enzymology Inflammation / genetics Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 / deficiency Leukocytes / enzymology Male Mice, Inbred C57BL Mutation / genetics Reactive Oxygen Species / metabolism Reoviridae / physiology Salmonella typhimurium / growth & development Sepsis / microbiology Sex Characteristics Survival Analysis alpha-Synuclein / metabolism

Journal

Science translational medicine
ISSN: 1946-6242
Titre abrégé: Sci Transl Med
Pays: United States
ID NLM: 101505086

Informations de publication

Date de publication:
25 09 2019
Historique:
received: 05 01 2018
revised: 27 12 2018
accepted: 11 05 2019
entrez: 27 9 2019
pubmed: 27 9 2019
medline: 21 8 2020
Statut: ppublish

Résumé

Variants in the leucine-rich repeat kinase-2 (

Identifiants

DOI: 10.1126/scitranslmed.aas9292 PMID: 31554740
pubmed: 31554740
pii: 11/511/eaas9292
doi: 10.1126/scitranslmed.aas9292
pii:
doi:

Substances chimiques

Reactive Oxygen Species 0
alpha-Synuclein 0
Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 EC 2.7.11.1

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.

Auteurs

Bojan Shutinoski (B)

Program in Neuroscience, Ottawa Hospital Research Institute, University of Ottawa, Ottawa, ON, Canada.
Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON, Canada.
ORCID: 0000-0003-4669-5656

Mansoureh Hakimi (M)

Program in Neuroscience, Ottawa Hospital Research Institute, University of Ottawa, Ottawa, ON, Canada.
Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, ON, Canada.
ORCID: 0000-0002-6011-8719

Irene E Harmsen (IE)

Program in Neuroscience, Ottawa Hospital Research Institute, University of Ottawa, Ottawa, ON, Canada.
ORCID: 0000-0001-9056-1706

Michaela Lunn (M)

Program in Neuroscience, Ottawa Hospital Research Institute, University of Ottawa, Ottawa, ON, Canada.
Department of Neuroscience, Carleton University, Ottawa, ON, Canada.
ORCID: 0000-0003-0876-8017

Juliana Rocha (J)

Department of Immunology, University of Toronto, Toronto, ON, Canada.
ORCID: 0000-0002-0814-7088

Nathalie Lengacher (N)

Program in Neuroscience, Ottawa Hospital Research Institute, University of Ottawa, Ottawa, ON, Canada.
ORCID: 0000-0002-2536-1895

Yi Yuan Zhou (YY)

Program in Neuroscience, Ottawa Hospital Research Institute, University of Ottawa, Ottawa, ON, Canada.
ORCID: 0000-0003-4997-3412

Jasmine Khan (J)

Program in Neuroscience, Ottawa Hospital Research Institute, University of Ottawa, Ottawa, ON, Canada.
ORCID: 0000-0002-5765-2371

Angela Nguyen (A)

Program in Neuroscience, Ottawa Hospital Research Institute, University of Ottawa, Ottawa, ON, Canada.
ORCID: 0000-0002-7453-2232

Quinton Hake-Volling (Q)

Program in Neuroscience, Ottawa Hospital Research Institute, University of Ottawa, Ottawa, ON, Canada.
ORCID: 0000-0001-6002-7684

Daniel El-Kodsi (D)

Program in Neuroscience, Ottawa Hospital Research Institute, University of Ottawa, Ottawa, ON, Canada.
ORCID: 0000-0002-8896-0043

Juan Li (J)

Program in Neuroscience, Ottawa Hospital Research Institute, University of Ottawa, Ottawa, ON, Canada.
ORCID: 0000-0003-1565-2477

Azadeh Alikashani (A)

Research Centre, Montreal Heart Institute, Montréal, QC, Canada.
Faculty of Medicine, Université de Montréal, Montréal, QC, Canada.
ORCID: 0000-0002-9035-0615

Claudine Beauchamp (C)

Research Centre, Montreal Heart Institute, Montréal, QC, Canada.
Faculty of Medicine, Université de Montréal, Montréal, QC, Canada.

Jay Majithia (J)

Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON, Canada.

Kevin Coombs (K)

Department of Medical Microbiology, University of Manitoba, Winnipeg, MB, Canada.
ORCID: 0000-0001-7667-8430

Derya Shimshek (D)

Novartis Institutes of BioMedical Research, Novartis Campus, CH-4056 Basel, Switzerland.
ORCID: 0000-0001-8602-7850

Paul C Marcogliese (PC)

Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, ON, Canada.
University of Ottawa Brain and Mind Research Institute, University of Ottawa, Ottawa, ON, Canada.
ORCID: 0000-0002-8011-7852

David S Park (DS)

Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, ON, Canada.
University of Ottawa Brain and Mind Research Institute, University of Ottawa, Ottawa, ON, Canada.
ORCID: 0000-0002-4490-3784

John D Rioux (JD)

Research Centre, Montreal Heart Institute, Montréal, QC, Canada.
Faculty of Medicine, Université de Montréal, Montréal, QC, Canada.
ORCID: 0000-0001-7560-8326

Dana J Philpott (DJ)

Department of Immunology, University of Toronto, Toronto, ON, Canada.

John M Woulfe (JM)

Program in Neuroscience, Ottawa Hospital Research Institute, University of Ottawa, Ottawa, ON, Canada.
Department of Pathology and Laboratory Medicine, University of Ottawa, Ottawa, ON, Canada.

Shawn Hayley (S)

Department of Neuroscience, Carleton University, Ottawa, ON, Canada.

Subash Sad (S)

Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON, Canada.

Julianna J Tomlinson (JJ)

Program in Neuroscience, Ottawa Hospital Research Institute, University of Ottawa, Ottawa, ON, Canada.
University of Ottawa Brain and Mind Research Institute, University of Ottawa, Ottawa, ON, Canada.
ORCID: 0000-0003-2997-5162

Earl G Brown (EG)

Program in Neuroscience, Ottawa Hospital Research Institute, University of Ottawa, Ottawa, ON, Canada.
Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON, Canada.

Michael G Schlossmacher (MG)

Program in Neuroscience, Ottawa Hospital Research Institute, University of Ottawa, Ottawa, ON, Canada. mschlossmacher@ohri.ca.
Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, ON, Canada.
University of Ottawa Brain and Mind Research Institute, University of Ottawa, Ottawa, ON, Canada.
Division of Neurology, Department of Medicine, Ottawa Hospital, University of Ottawa, Ottawa, ON, Canada.
ORCID: 0000-0002-0394-0300

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Classifications MeSH

questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Composants de génome › Gènes › Allèles ›
questionsmedicales.fr › Eucaryotes › Animaux ›
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale ›
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système locomoteur › Mouvement › Locomotion › Taxie › Chimiotaxie ›
questionsmedicales.fr › Maladies du système nerveux › Encéphalite ›
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains ›
questionsmedicales.fr › Infection ›
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Inflammation ›
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines associées à la maladie de Parkinson › Leucine-rich repeat serine-threonine protein kinase-2 ›
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes ›
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL ›
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Mutation ›
questionsmedicales.fr › Produits chimiques inorganiques › Composés de l'oxygène › Espèces réactives de l'oxygène ›
questionsmedicales.fr › Virus › Virus à ARN › Virus à ARN double brin › Reoviridae ›
questionsmedicales.fr › Bactéries › Proteobacteria › Gammaproteobacteria › Enterobacteriaceae › Salmonella › Salmonella enterica › Salmonella typhimurium ›
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Inflammation › Sepsie ›
questionsmedicales.fr › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques de la reproduction › Caractères sexuels ›
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Analyse de survie ›
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines associées à la maladie de Parkinson › alpha-Synucléine ›