Tryptophan alleviates neuroendocrine and behavioral responses to stress in zebrafish.
Anxiety
Behavior
Cortisol
Fluoxetine
Zebrafish
Journal
Behavioural brain research
ISSN: 1872-7549
Titre abrégé: Behav Brain Res
Pays: Netherlands
ID NLM: 8004872
Informations de publication
Date de publication:
27 01 2020
27 01 2020
Historique:
received:
13
05
2019
revised:
25
09
2019
accepted:
26
09
2019
pubmed:
1
10
2019
medline:
30
4
2021
entrez:
1
10
2019
Statut:
ppublish
Résumé
Stressful experiences are related to the triggering of anxiety and mood disorders. Tryptophan (amino acid precursor of serotonin synthesis) emerges as important treatment of these disorders. Here, we evaluate the effects of pre-treatment with tryptophan (300 mg/L) and fluoxetine (50 μg/L) in response to acute stress in zebrafish. Overall, acute stress decreased the distance traveled, entries and time in top of tank, as well as increased the cortisol levels, demonstrating an anxiogenic behavior. Tryptophan and fluoxetine prevented anxiogenic effects. This study showed the importance of tryptophan and fluoxetine in the regulation of stress and anxiety-like behavior in adult zebrafish. Collectively, our data support tryptophan effects on stress responses in zebrafish and reinforce the growing utility of this aquatic model to screen CNS therapies.
Identifiants
pubmed: 31568833
pii: S0166-4328(19)30735-1
doi: 10.1016/j.bbr.2019.112264
pii:
doi:
Substances chimiques
Serotonin Agents
0
Fluoxetine
01K63SUP8D
Tryptophan
8DUH1N11BX
Hydrocortisone
WI4X0X7BPJ
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
112264Informations de copyright
Copyright © 2019 Elsevier B.V. All rights reserved.