The FANCM family Mph1 helicase localizes to the mitochondria and contributes to mtDNA stability.
Double-strand break
Fanconi Anemia-like pathway
Helicase Mph1
Homologous recombination
Mitochondrial DNA repair
Journal
DNA repair
ISSN: 1568-7856
Titre abrégé: DNA Repair (Amst)
Pays: Netherlands
ID NLM: 101139138
Informations de publication
Date de publication:
10 2019
10 2019
Historique:
received:
12
03
2019
revised:
31
07
2019
accepted:
03
08
2019
pubmed:
1
10
2019
medline:
12
5
2020
entrez:
1
10
2019
Statut:
ppublish
Résumé
Mitochondria are membrane-bound organelles found in eukaryotic cells where they generate energy through the respiratory chain. They contain their own genome that encodes genes critical to the mitochondrial function, but most of their protein content is synthetized from nuclear encoded genes. Damages to the mtDNA can cause mutations and rearrangements with an impact on the respiratory functions of the cell. DNA repair factors are able to localize to mitochondria to restore mtDNA integrity and ensure its proper inheritance. We describe in this article the mitochondrial localization of the Mph1/FANCM helicase that serves critical roles in nuclear DNA repair processes. Mph1 localizes to mitochondria and its functions contribute to the mtDNA integrity under mtDNA damaging conditions.
Identifiants
pubmed: 31569000
pii: S1568-7864(19)30086-2
doi: 10.1016/j.dnarep.2019.102684
pii:
doi:
Substances chimiques
DNA, Mitochondrial
0
Saccharomyces cerevisiae Proteins
0
MPH1 protein, S cerevisiae
EC 3.6.1.-
DEAD-box RNA Helicases
EC 3.6.4.13
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
102684Informations de copyright
Copyright © 2019 Elsevier B.V. All rights reserved.