Aging Triggers H3K27 Trimethylation Hoarding in the Chromatin of


Journal

Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052

Informations de publication

Date de publication:
28 09 2019
Historique:
received: 30 07 2019
revised: 15 09 2019
accepted: 26 09 2019
entrez: 2 10 2019
pubmed: 2 10 2019
medline: 17 6 2020
Statut: epublish

Résumé

Aging associates with progressive loss of skeletal muscle function, sometimes leading to sarcopenia, a process characterized by impaired mobility and weakening of muscle strength. Since aging associates with profound epigenetic changes, epigenetic landscape alteration analysis in the skeletal muscle promises to highlight molecular mechanisms of age-associated alteration in skeletal muscle. This study was conducted exploiting the short-lived turquoise killifish

Identifiants

pubmed: 31569376
pii: cells8101169
doi: 10.3390/cells8101169
pmc: PMC6829443
pii:
doi:

Substances chimiques

Chromosomal Proteins, Non-Histone 0
Fish Proteins 0
Heterochromatin 0
Histones 0
Chromobox Protein Homolog 5 107283-02-3

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

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Auteurs

Chiara Cencioni (C)

National Research Council, Institute for Systems Analysis and Computer Science, 00185 Rome, Italy. chcencioni@gmail.com.

Johanna Heid (J)

Department of Genetics, Albert Einstein College of Medicine, Bronx, NY 10461, USA. johanna.heid@einstein.yu.edu.

Anna Krepelova (A)

Leibniz Institute on Aging - Fritz Lipmann Institute (FLI), 07745 Jena, Germany. Anna.Krepelova@leibniz-fli.de.

Seyed Mohammad Mahdi Rasa (SMM)

Leibniz Institute on Aging - Fritz Lipmann Institute (FLI), 07745 Jena, Germany. Mahdi.Rasa@leibniz-fli.de.

Carsten Kuenne (C)

ECCPS Bioinformatics and deep sequencing platform, Max Planck Institute for Heart and Lung Research, 61231 Bad Nauheim, Germany. carsten.kuenne@mpi-bn.mpg.de.

Stefan Guenther (S)

ECCPS Bioinformatics and deep sequencing platform, Max Planck Institute for Heart and Lung Research, 61231 Bad Nauheim, Germany. Stefan.Guenther@mpi-bn.mpg.de.

Mario Baumgart (M)

Leibniz Institute on Aging - Fritz Lipmann Institute (FLI), 07745 Jena, Germany. Mario.Baumgart@leibniz-fli.de.

Alessandro Cellerino (A)

Laboratory of Biology (Bio@SNS), Scuola Normale Superiore, c/o Istituto di Biofisica del CNR, 56124 Pisa, Italy. alessandro.cellerino@gmail.com.

Francesco Neri (F)

Leibniz Institute on Aging - Fritz Lipmann Institute (FLI), 07745 Jena, Germany. francesco.neri@leibniz-fli.de.

Francesco Spallotta (F)

Department of Oncology, University of Turin, 10060 Candiolo (TO), Italy. francesco.spallotta@unito.it.
Candiolo Cancer Institute, FPO-IRCCS, 10060 Candiolo (TO), Italy. francesco.spallotta@unito.it.

Carlo Gaetano (C)

Laboratory of Epigenetics, Istituti Clinici Scientifici Maugeri IRCCS, 27100 Pavia, Italy. carlo.gaetano@icsmaugeri.it.

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Classifications MeSH