Pyruvate Substitutions on Glycoconjugates.

N-glycans biosynthesis capsular polysaccharides cell wall glycopolymers exopolysaccharides lipopolysaccharides pyruvate analytics pyruvylation pyruvyltransferase sequence space

Journal

International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791

Informations de publication

Date de publication:
05 Oct 2019
Historique:
received: 13 08 2019
revised: 25 09 2019
accepted: 27 09 2019
entrez: 9 10 2019
pubmed: 9 10 2019
medline: 11 2 2020
Statut: epublish

Résumé

Glycoconjugates are the most diverse biomolecules of life. Mostly located at the cell surface, they translate into cell-specific "barcodes" and offer a vast repertoire of functions, including support of cellular physiology, lifestyle, and pathogenicity. Functions can be fine-tuned by non-carbohydrate modifications on the constituting monosaccharides. Among these modifications is pyruvylation, which is present either in enol or ketal form. The most commonly best-understood example of pyruvylation is enol-pyruvylation of

Identifiants

pubmed: 31590345
pii: ijms20194929
doi: 10.3390/ijms20194929
pmc: PMC6801904
pii:
doi:

Substances chimiques

Bacterial Proteins 0
Glycoconjugates 0
Pyruvates 0
Acyltransferases EC 2.3.-
ketal pyruvate transferase EC 2.3.1.-

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : Austrian Science Fund
ID : P31521-B22
Organisme : Hochschuljubiläumsstiftung der Stadt Wien
ID : H-318348/2018
Organisme : Austrian Science Fund
ID : P27374-B22
Organisme : Austrian Science Fund FWF
ID : P 27374
Pays : Austria
Organisme : Austrian Science Fund FWF
ID : W 1224
Pays : Austria

Déclaration de conflit d'intérêts

The authors declare no conflict of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript, or in the decision to publish the results.

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Auteurs

Fiona F Hager (FF)

Department of NanoBiotechnology, NanoGlycobiology unit, Universität für Bodenkultur Wien, Muthgasse 11, A-1190 Vienna, Austria. fiona.hager@boku.ac.at.

Leander Sützl (L)

Department of Food Science and Technology, Food Biotechnology Laboratory, Muthgasse 11, Universität für Bodenkultur Wien, A-1190 Vienna, Austria. leander.suetzl@boku.ac.at.

Cordula Stefanović (C)

Department of NanoBiotechnology, NanoGlycobiology unit, Universität für Bodenkultur Wien, Muthgasse 11, A-1190 Vienna, Austria. cordula.brinskele@boku.ac.at.

Markus Blaukopf (M)

Department of Chemistry, Division of Organic Chemistry, Universität für Bodenkultur Wien, Muthgasse 18, A-1190 Vienna, Austria. markus.blaukopf@boku.ac.at.

Christina Schäffer (C)

Department of NanoBiotechnology, NanoGlycobiology unit, Universität für Bodenkultur Wien, Muthgasse 11, A-1190 Vienna, Austria. christina.schaeffer@boku.ac.at.

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Classifications MeSH