A clonal expression biomarker associates with lung cancer mortality.

Aged Biomarkers, Tumor / genetics Clonal Evolution / genetics DNA Copy Number Variations / genetics Disease-Free Survival Exome / genetics Female Gene Expression Regulation, Neoplastic Genetic Heterogeneity Humans Lung Neoplasms / genetics Male Prognosis Risk Factors Transcriptome / genetics Exome Sequencing

Journal

Nature medicine
ISSN: 1546-170X
Titre abrégé: Nat Med
Pays: United States
ID NLM: 9502015

Informations de publication

Date de publication:
10 2019
Historique:
received: 12 11 2018
accepted: 20 08 2019
pubmed: 9 10 2019
medline: 22 1 2020
entrez: 9 10 2019
Statut: ppublish

Résumé

An aim of molecular biomarkers is to stratify patients with cancer into disease subtypes predictive of outcome, improving diagnostic precision beyond clinical descriptors such as tumor stage

Identifiants

DOI: 10.1038/s41591-019-0595-z PMID: 31591602 PMC: PMC6984959
pubmed: 31591602
doi: 10.1038/s41591-019-0595-z
pii: 10.1038/s41591-019-0595-z
pmc: PMC6984959
mid: EMS85497
doi:

Substances chimiques

Biomarkers, Tumor 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1540-1548

Subventions

Organisme : Medical Research Council
ID : FC001169
Pays : United Kingdom
Organisme : Cancer Research UK
ID : FC001169
Pays : United Kingdom
Organisme : Arthritis Research UK
ID : FC001202
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 211179
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UP_1203/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/P014712/1
Pays : United Kingdom
Organisme : Arthritis Research UK
ID : FC001169
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/M009033/1
Pays : United Kingdom
Organisme : Wellcome Trust
ID : FC001169
Pays : United Kingdom
Organisme : Wellcome Trust
Pays : United Kingdom

Investigateurs

Charles Swanton (C)
Mariam Jamal-Hanjani (M)
Christopher Abbosh (C)
Yin Wu (Y)
Selvaraju Veeriah (S)
Marcin Skrzypski (M)
Rachel Rosenthal (R)
Dhruva Biswas (D)
Nicholas McGranahan (N)
Gareth A Wilson (GA)
Emilia L Lim (EL)
Crispin T Hiley (CT)
Nicolai J Birkbak (NJ)
Maria Greco (M)
David A Moore (DA)
Javier Herrero (J)
Allan Hackshaw (A)
Thomas B K Watkins (TBK)
Maise Al Bakir (MA)
Kevin Litchfield (K)
Istvan Csabai (I)
Stefan Boeing (S)
Zoltan Szallasi (Z)
Yenting Ngai (Y)
Abigail Sharp (A)
Cristina Rodrigues (C)
Oliver Pressey (O)
Sean Smith (S)
Nicole Gower (N)
Harjot Dhanda (H)
Miklos Diossy (M)
Mickael Escudero (M)
Aengus Stewart (A)
Andrew Rowan (A)
Jacki Goldman (J)
Peter Van Loo (P)
Richard Kevin Stone (RK)
Tamara Denner (T)
Emma Nye (E)
Sophia Ward (S)
Jerome Nicod (J)
Clare Puttick (C)
Katey Enfield (K)
Emma Colliver (E)
Brittany Campbell (B)
Robert E Hynds (RE)
Andrew Georgiou (A)
Mariana Werner Sunderland (MW)
James L Reading (JL)
Sergio A Quezada (SA)
Karl S Peggs (KS)
Teresa Marafioti (T)
John A Hartley (JA)
Pat Gorman (P)
Helen L Lowe (HL)
Leah Ensell (L)
Victoria Spanswick (V)
Angeliki Karamani (A)
Maryam Razaq (M)
Stephan Beck (S)
Ariana Huebner (A)
Michelle Dietzen (M)
Cristina Naceur-Lombardelli (C)
Mita Afroza Akther (MA)
Haoran Zhai (H)
Nnennaya Kannu (N)
Elizabeth Manzano (E)
Supreet Kaur Bola (SK)
Ehsan Ghorani (E)
Marc Robert de Massy (MR)
Elena Hoxha (E)
Emine Hatipoglu (E)
Stephanie Ogwuru (S)
Benny Chain (B)
David Lawrence (D)
Martin Hayward (M)
Nikolaos Panagiotopoulos (N)
Robert George (R)
Davide Patrini (D)
Mary Falzon (M)
Elaine Borg (E)
Reena Khiroya (R)
Asia Ahmed (A)
Magali Taylor (M)
Junaid Choudhary (J)
Penny Shaw (P)
Sam M Janes (SM)
Martin Forster (M)
Tanya Ahmad (T)
Siow Ming Lee (SM)
Dawn Carnell (D)
Ruheena Mendes (R)
Jeremy George (J)
Neal Navani (N)
Dionysis Papadatos-Pastos (D)
Marco Scarci (M)
Elisa Bertoja (E)
Robert C M Stephens (RCM)
Emilie Martinoni Hoogenboom (EM)
James W Holding (JW)
Steve Bandula (S)
Gillian Price (G)
Sylvie Dubois-Marshall (S)
Keith Kerr (K)
Shirley Palmer (S)
Heather Cheyne (H)
Joy Miller (J)
Keith Buchan (K)
Mahendran Chetty (M)
Mohammed Khalil (M)
Veni Ezhil (V)
Vineet Prakash (V)
Girija Anand (G)
Sajid Khan (S)
Kelvin Lau (K)
Michael Sheaff (M)
Peter Schmid (P)
Louise Lim (L)
John Conibear (J)
Roland Schwarz (R)
Jonathan Tugwood (J)
Jackie Pierce (J)
Caroline Dive (C)
Ged Brady (G)
Dominic G Rothwell (DG)
Francesca Chemi (F)
Elaine Kilgour (E)
Fiona Blackhall (F)
Lynsey Priest (L)
Matthew G Krebs (MG)
Philip Crosbie (P)
John Le Quesne (J)
Joan Riley (J)
Lindsay Primrose (L)
Luke Martinson (L)
Nicolas Carey (N)
Jacqui A Shaw (JA)
Dean Fennell (D)
Apostolos Nakas (A)
Sridhar Rathinam (S)
Louise Nelson (L)
Kim Ryanna (K)
Mohamad Tuffail (M)
Amrita Bajaj (A)
Jan Brozik (J)
Fiona Morgan (F)
Malgorzata Kornaszewska (M)
Richard Attanoos (R)
Haydn Adams (H)
Helen Davies (H)
Mathew Carter (M)
Colin R Lindsay (CR)
Fabio Gomes (F)
Roberto Salgado (R)
Hugo Aerts (H)
Alan Kirk (A)
Mo Asif (M)
John Butler (J)
Rocco Bilanca (R)
Nikos Kostoulas (N)
Mairead MacKenzie (M)
Maggie Wilcox (M)
Sara Busacca (S)
Alan Dawson (A)
Mark R Lovett (MR)
Michael Shackcloth (M)
Sarah Feeney (S)
Julius Asante-Siaw (J)
John Gosney (J)
Angela Leek (A)
Nicola Totten (N)
Jack Davies Hodgkinson (JD)
Rachael Waddington (R)
Jane Rogan (J)
Katrina Moore (K)
William Monteiro (W)
Hilary Marshall (H)
Kevin G Blyth (KG)
Craig Dick (C)
Andrew Kidd (A)
Eric Lim (E)
Paulo De Sousa (P)
Simon Jordan (S)
Alexandra Rice (A)
Hilgardt Raubenheimer (H)
Harshil Bhayani (H)
Morag Hamilton (M)
Lyn Ambrose (L)
Anand Devaraj (A)
Hema Chavan (H)
Sofina Begum (S)
Aleksander Mani (A)
Daniel Kaniu (D)
Mpho Malima (M)
Sarah Booth (S)
Andrew G Nicholson (AG)
Nadia Fernandes (N)
Jessica E Wallen (JE)
Pratibha Shah (P)
Sarah Danson (S)
Jonathan Bury (J)
John Edwards (J)
Jennifer Hill (J)
Sue Matthews (S)
Yota Kitsanta (Y)
Jagan Rao (J)
Sara Tenconi (S)
Laura Socci (L)
Kim Suvarna (K)
Faith Kibutu (F)
Patricia Fisher (P)
Robin Young (R)
Joann Barker (J)
Fiona Taylor (F)
Kirsty Lloyd (K)
Teresa Light (T)
Tracey Horey (T)
Dionysis Papadatos-Pastos (D)
Peter Russell (P)
Sara Lock (S)
Kayleigh Gilbert (K)
Babu Naidu (B)
Gerald Langman (G)
Andrew Robinson (A)
Hollie Bancroft (H)
Amy Kerr (A)
Salma Kadiri (S)
Charlotte Ferris (C)
Gary Middleton (G)
Madava Djearaman (M)
Akshay Patel (A)
Christian Ottensmeier (C)
Serena Chee (S)
Benjamin Johnson (B)
Aiman Alzetani (A)
Emily Shaw (E)
Jason Lester (J)
Yvonne Summers (Y)
Raffaele Califano (R)
Paul Taylor (P)
Rajesh Shah (R)
Piotr Krysiak (P)
Kendadai Rammohan (K)
Eustace Fontaine (E)
Richard Booton (R)
Matthew Evison (M)
Stuart Moss (S)
Juliette Novasio (J)
Leena Joseph (L)
Paul Bishop (P)
Anshuman Chaturvedi (A)
Helen Doran (H)
Felice Granato (F)
Vijay Joshi (V)
Elaine Smith (E)
Angeles Montero (A)

Commentaires et corrections

Type : CommentIn
Type : ErratumIn
Type : CommentIn

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Auteurs

Dhruva Biswas (D)

Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, Paul O'Gorman Building, London, UK.
Bill Lyons Informatics Centre, University College London Cancer Institute, Paul O'Gorman Building, London, UK.
Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London, UK.

Nicolai J Birkbak (NJ)

Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, Paul O'Gorman Building, London, UK. nbirkbak@clin.au.dk.
Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London, UK. nbirkbak@clin.au.dk.
Department of Molecular Medicine, Aarhus University, Aarhus, Denmark. nbirkbak@clin.au.dk.
Bioinformatics Research Centre, Aarhus University, Aarhus, Denmark. nbirkbak@clin.au.dk.
ORCID: 0000-0003-1613-9587

Rachel Rosenthal (R)

Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, Paul O'Gorman Building, London, UK.
Bill Lyons Informatics Centre, University College London Cancer Institute, Paul O'Gorman Building, London, UK.
Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London, UK.

Crispin T Hiley (CT)

Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, Paul O'Gorman Building, London, UK.
Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London, UK.

Emilia L Lim (EL)

Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, Paul O'Gorman Building, London, UK.
Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London, UK.

Krisztian Papp (K)

Department of Physics of Complex Systems, ELTE Eötvös Loránd University, Budapest, Hungary.
ORCID: 0000-0003-0619-8233

Stefan Boeing (S)

Bioinformatics and Biostatistics, The Francis Crick Institute, London, UK.

Marcin Krzystanek (M)

Danish Cancer Society Research Center, Copenhagen, Denmark.

Dijana Djureinovic (D)

Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.

Linnea La Fleur (L)

Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.

Maria Greco (M)

Genomics Equipment Park, The Francis Crick Institute, London, UK.

Balázs Döme (B)

Department of Tumor Biology, National Korányi Institute of Pulmonology, Semmelweis University, Budapest, Hungary.
Division of Thoracic Surgery, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria.
Department of Thoracic Surgery, National Institute of Oncology, Semmelweis University, Budapest, Hungary.

János Fillinger (J)

Department of Pathology, National Korányi Institute of Pulmonology, Semmelweis University, Budapest, Hungary.
Department of Pathology, National Institute of Oncology, Budapest, Hungary.

Hans Brunnström (H)

Lund University, Laboratory Medicine Region Skåne, Department of Clinical Sciences Lund, Pathology, Lund, Sweden.
ORCID: 0000-0001-7402-138X

Yin Wu (Y)

Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, Paul O'Gorman Building, London, UK.

David A Moore (DA)

Department of Pathology, UCL Cancer Institute, London, UK.

Marcin Skrzypski (M)

Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, Paul O'Gorman Building, London, UK.
Department of Oncology and Radiotherapy, Medical University of Gdansk, Gdansk, Poland.

Christopher Abbosh (C)

Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, Paul O'Gorman Building, London, UK.

Kevin Litchfield (K)

Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London, UK.

Maise Al Bakir (M)

Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London, UK.

Thomas B K Watkins (TBK)

Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London, UK.

Selvaraju Veeriah (S)

Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, Paul O'Gorman Building, London, UK.

Gareth A Wilson (GA)

Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, Paul O'Gorman Building, London, UK.
Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London, UK.

Mariam Jamal-Hanjani (M)

Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, Paul O'Gorman Building, London, UK.

Judit Moldvay (J)

Department of Tumor Biology, National Korányi Institute of Pulmonology, Semmelweis University, Budapest, Hungary.
SE-NAP Brain Metastasis Research Group, 2nd Department of Pathology, Semmelweis University, Budapest, Hungary.

Johan Botling (J)

Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.

Arul M Chinnaiyan (AM)

Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, MI, USA.
Department of Pathology, University of Michigan, Ann Arbor, MI, USA.
Rogel Cancer Center, University of Michigan, Ann Arbor, Michigan, USA.
Department of Urology, University of Michigan, Ann Arbor, MI, USA.
Howard Hughes Medical Institute, University of Michigan, Ann Arbor, MI, USA.

Patrick Micke (P)

Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.

Allan Hackshaw (A)

Cancer Research UK & University College London Cancer Trials Centre, University College London, London, UK.

Jiri Bartek (J)

Danish Cancer Society Research Center, Copenhagen, Denmark.
Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden.

Istvan Csabai (I)

Department of Physics of Complex Systems, ELTE Eötvös Loránd University, Budapest, Hungary.

Zoltan Szallasi (Z)

Danish Cancer Society Research Center, Copenhagen, Denmark.
SE-NAP Brain Metastasis Research Group, 2nd Department of Pathology, Semmelweis University, Budapest, Hungary.
Computational Health Informatics Program, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.

Javier Herrero (J)

Bill Lyons Informatics Centre, University College London Cancer Institute, Paul O'Gorman Building, London, UK.
ORCID: 0000-0001-7313-717X

Nicholas McGranahan (N)

Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, Paul O'Gorman Building, London, UK. nicholas.mcgranahan.10@ucl.ac.uk.
Cancer Genome Evolution Research Group, University College London Cancer Institute, University College London, London, UK. nicholas.mcgranahan.10@ucl.ac.uk.
ORCID: 0000-0001-9537-4045

Charles Swanton (C)

Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, Paul O'Gorman Building, London, UK. charles.swanton@crick.ac.uk.
Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London, UK. charles.swanton@crick.ac.uk.
ORCID: 0000-0002-4299-3018

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › A clonal expression biomarker associates with...
questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Marqueurs biologiques tumoraux › A clonal expression biomarker associates with...
questionsmedicales.fr › Phénomènes génétiques › Évolution clonale › A clonal expression biomarker associates with...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Polymorphisme génétique › Variation structurale du génome › Variations de nombre de copies de segment d'ADN › A clonal expression biomarker associates with...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Analyse de survie › Survie sans rechute › A clonal expression biomarker associates with...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Exome › A clonal expression biomarker associates with...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Régulation de l'expression des gènes tumoraux › A clonal expression biomarker associates with...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Hétérogénéité génétique › A clonal expression biomarker associates with...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › A clonal expression biomarker associates with...
questionsmedicales.fr › Maladies de l'appareil respiratoire › Tumeurs de l'appareil respiratoire › Tumeurs du poumon › A clonal expression biomarker associates with...
questionsmedicales.fr › Diagnostic › Pronostic › A clonal expression biomarker associates with...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Probabilité › Risque › Facteurs de risque › A clonal expression biomarker associates with...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Transcriptome › A clonal expression biomarker associates with...
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Analyse de séquence › Analyse de séquence d'ADN › Séquençage du génome entier › Séquençage de l'exome › A clonal expression biomarker associates with...