In-situ photopolymerized polyhedral oligomeric silsesquioxane-derived monolithic capillary columns with quinidine functionality for enantioseparation by nano-liquid chromatography.
Chiral stationary phase
Enantiomer separation
Inorganic-organic hybrid monolith
Nano-HPLC
Photopolymerization
Journal
Electrophoresis
ISSN: 1522-2683
Titre abrégé: Electrophoresis
Pays: Germany
ID NLM: 8204476
Informations de publication
Date de publication:
12 2019
12 2019
Historique:
received:
27
08
2019
revised:
03
10
2019
accepted:
04
10
2019
pubmed:
9
10
2019
medline:
21
4
2020
entrez:
9
10
2019
Statut:
ppublish
Résumé
The successful fabrication of monolithic capillary columns for enantiomer separations was achieved within vinylized fused silica capillaries via fast "one-pot" photo-initiated free radical polymerization reaction. A mixture consisting of polyhedral oligomeric silsesquioxane, O-[2-(methacryloyloxy)ethylcarbamoyl]-10,11-dihydroquinidine was copolymerized in the presence of n-butanol, ethylene glycol and photo-initiator 2,2-dimethoxy-2-phenylacetophenone. The morphology of the resultant polymeric hybrid inorganic-organic material and its permeability as well as porosity can be controlled by adjusting the composition of the monomers and binary porogenic solvent. The chromatographic characteristics of the columns have been investigated. Separation factors of N-acetyl-phenylalanine (Ac-Phe) and dichlorprop dropped with decrease of chiral functional monomer. Permeability was better when the macroporogen ethyleneglycol was present at higher concentrations during the polymerization. In general, the chiral compounds were well separated (dichlorprop: α = 1.53, R
Identifiants
pubmed: 31591731
doi: 10.1002/elps.201900316
doi:
Substances chimiques
Organosilicon Compounds
0
2,4-Dichlorophenoxyacetic Acid
2577AQ9262
Quinidine
ITX08688JL
dichlorprop
J7YV2RKO6Q
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
3132-3139Subventions
Organisme : China Scholarship Council
ID : 201506870009
Pays : International
Informations de copyright
© 2019 The Authors. Electrophoresis published by WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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