Animals
Anti-Bacterial Agents
/ pharmacology
Antifibrinolytic Agents
/ pharmacology
Collagen Type I
/ metabolism
Collagen Type IV
/ metabolism
Colon
/ drug effects
Disease Models, Animal
Enterococcus faecalis
/ drug effects
Fibrinolysis
/ drug effects
Gram-Positive Bacterial Infections
/ metabolism
Host-Pathogen Interactions
Humans
Mice, Inbred C57BL
Plasminogen
/ antagonists & inhibitors
Proteolysis
Pseudomonas Infections
/ metabolism
Surgical Wound Infection
/ metabolism
Tranexamic Acid
/ pharmacology
Urokinase-Type Plasminogen Activator
/ metabolism
Virulence
Wound Healing
/ drug effects
Enterococcus faecalis
gastrointestinal healing
plasminogen
Journal
American journal of physiology. Gastrointestinal and liver physiology
ISSN: 1522-1547
Titre abrégé: Am J Physiol Gastrointest Liver Physiol
Pays: United States
ID NLM: 100901227
Informations de publication
Date de publication:
01 01 2020
01 01 2020
Historique:
pubmed:
12
10
2019
medline:
6
5
2020
entrez:
12
10
2019
Statut:
ppublish
Résumé
Perforations, anastomotic leak, and subsequent intra-abdominal sepsis are among the most common and feared complications of invasive interventions in the colon and remaining intestinal tract. During physiological healing, tissue protease activity is finely orchestrated to maintain the strength and integrity of the submucosa collagen layer in the wound. We (Shogan, BD et al.
Identifiants
pubmed: 31604031
doi: 10.1152/ajpgi.00236.2019
pmc: PMC6985841
doi:
Substances chimiques
Anti-Bacterial Agents
0
Antifibrinolytic Agents
0
Collagen Type I
0
Collagen Type IV
0
Tranexamic Acid
6T84R30KC1
Plasminogen
9001-91-6
Urokinase-Type Plasminogen Activator
EC 3.4.21.73
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
G1-G9Subventions
Organisme : NIGMS NIH HHS
ID : R01 GM062344
Pays : United States
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