Lifelong Physical Activity Determines Vascular Function in Late Postmenopausal Women.
6-Ketoprostaglandin F1 alpha
/ blood
Acetylcholine
/ pharmacology
Aged
Cross-Sectional Studies
Endothelium, Vascular
/ physiology
Epoprostenol
/ pharmacology
Exercise
/ physiology
Female
Femoral Artery
/ physiology
Humans
Leg
/ blood supply
Middle Aged
Muscle, Skeletal
/ enzymology
Muscle, Smooth, Vascular
/ drug effects
Nitroprusside
/ pharmacology
Norepinephrine
/ blood
Postmenopause
/ physiology
Regional Blood Flow
Vasodilator Agents
/ pharmacology
Journal
Medicine and science in sports and exercise
ISSN: 1530-0315
Titre abrégé: Med Sci Sports Exerc
Pays: United States
ID NLM: 8005433
Informations de publication
Date de publication:
03 2020
03 2020
Historique:
pubmed:
15
10
2019
medline:
9
10
2020
entrez:
15
10
2019
Statut:
ppublish
Résumé
The study evaluated the role of lifelong physical activity for leg vascular function in postmenopausal women (61 ± 1 yr). The study design was cross-sectional with three different groups based on self-reported physical activity level with regard to intensity and volume over the past decade: inactive (n = 14), moderately active (n = 12), and very active (n = 15). Endothelial-dependent and smooth muscle-dependent leg vascular function were assessed by ultrasound Doppler measurements of the femoral artery during infusion of acetylcholine (Ach), the nitric oxide (NO) donor sodium nitroprusside and the prostacyclin analog epoprostenol. Thigh muscle biopsies, arterial and venous plasma samples were obtained for assessment of vasodilator systems. The very active group was found to have 76% greater responsiveness to Ach compared with the sedentary group accompanied by 200% higher prostacyclin synthesis during Ach infusion. Smooth muscle cell responsiveness to sodium nitroprusside and epoprostenol was not different between groups. The protein amount of endothelial NO synthase and endogenous antioxidant enzymes in muscle tissue was higher in the very active than the inactive group. The moderately active group had a similar endothelial and smooth muscle cell responsiveness as the inactive group. A secondary comparison with a smaller group (n = 5) of habitually active young (24 ± 2 yr) women indicated that smooth muscle cell responsiveness and endothelial responsiveness are affected by age per se. This study shows that leg vascular function and the potential to form prostacyclin and NO in late postmenopausal women, is influenced by the extent of lifelong physical activity.
Identifiants
pubmed: 31609299
doi: 10.1249/MSS.0000000000002180
pii: 00005768-202003000-00014
doi:
Substances chimiques
Vasodilator Agents
0
Nitroprusside
169D1260KM
6-Ketoprostaglandin F1 alpha
58962-34-8
Epoprostenol
DCR9Z582X0
Acetylcholine
N9YNS0M02X
Norepinephrine
X4W3ENH1CV
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
627-636Références
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