Cardiac power output accurately reflects external cardiac work over a wide range of inotropic states in pigs.
Adrenergic beta-Agonists
/ pharmacology
Animals
Disease Models, Animal
Dobutamine
/ pharmacology
Endotoxemia
/ physiopathology
Heart Failure
/ diagnosis
Hyperthermia, Induced
Hypothermia, Induced
Myocardial Infarction
/ diagnosis
Resuscitation
Sevoflurane
/ pharmacology
Stroke Volume
/ drug effects
Sus scrofa
Time Factors
Ventricular Fibrillation
/ diagnosis
Ventricular Function, Left
/ drug effects
Ventricular Pressure
/ drug effects
Acute heart failure
Cardiac power output
Cardiogenic shock
Ejection fraction
Stroke work
Journal
BMC cardiovascular disorders
ISSN: 1471-2261
Titre abrégé: BMC Cardiovasc Disord
Pays: England
ID NLM: 100968539
Informations de publication
Date de publication:
15 10 2019
15 10 2019
Historique:
received:
05
06
2019
accepted:
26
09
2019
entrez:
17
10
2019
pubmed:
17
10
2019
medline:
9
6
2020
Statut:
epublish
Résumé
Cardiac power output (CPO), derived from the product of cardiac output and mean aortic pressure, is an important yet underexploited parameter for hemodynamic monitoring of critically ill patients in the intensive-care unit (ICU). The conductance catheter-derived pressure-volume loop area reflects left ventricular stroke work (LV SW). Dividing LV SW by time, a measure of LV SW min We retrospectively analysed data obtained from experimental studies of the hemodynamic impact of mild hypothermia and hyperthermia on acute heart failure. Fifty-nine anaesthetized and mechanically ventilated closed-chest Landrace pigs (68 ± 1 kg) were instrumented with Swan-Ganz and LV pressure-volume catheters. Data were obtained at body temperatures of 33.0 °C, 38.0 °C and 40.5 °C; before and after: resuscitation, myocardial infarction, endotoxemia, sevoflurane-induced myocardial depression and beta-adrenergic stimulation. We plotted LVSW min CPO showed the best correlation with LV SW min CPO reflects external cardiac work over a wide range of inotropic states. These data further support the use of CPO to monitor inotropic interventions in the ICU.
Sections du résumé
BACKGROUND
Cardiac power output (CPO), derived from the product of cardiac output and mean aortic pressure, is an important yet underexploited parameter for hemodynamic monitoring of critically ill patients in the intensive-care unit (ICU). The conductance catheter-derived pressure-volume loop area reflects left ventricular stroke work (LV SW). Dividing LV SW by time, a measure of LV SW min
METHODS
We retrospectively analysed data obtained from experimental studies of the hemodynamic impact of mild hypothermia and hyperthermia on acute heart failure. Fifty-nine anaesthetized and mechanically ventilated closed-chest Landrace pigs (68 ± 1 kg) were instrumented with Swan-Ganz and LV pressure-volume catheters. Data were obtained at body temperatures of 33.0 °C, 38.0 °C and 40.5 °C; before and after: resuscitation, myocardial infarction, endotoxemia, sevoflurane-induced myocardial depression and beta-adrenergic stimulation. We plotted LVSW min
RESULTS
CPO showed the best correlation with LV SW min
CONCLUSION
CPO reflects external cardiac work over a wide range of inotropic states. These data further support the use of CPO to monitor inotropic interventions in the ICU.
Identifiants
pubmed: 31615415
doi: 10.1186/s12872-019-1212-2
pii: 10.1186/s12872-019-1212-2
pmc: PMC6792198
doi:
Substances chimiques
Adrenergic beta-Agonists
0
Sevoflurane
38LVP0K73A
Dobutamine
3S12J47372
Types de publication
Comparative Study
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
217Références
Eur Heart J. 2001 Aug;22(16):1496-503
pubmed: 11482923
Crit Care Med. 2016 Mar;44(3):e158-67
pubmed: 26474110
Am J Med. 2005 May;118(5):482-8
pubmed: 15866250
Circulation. 1978 Mar;57(3):549-56
pubmed: 624164
Circulation. 1987 Dec;76(6):1422-36
pubmed: 3454658
Anesth Analg. 1995 May;80(5):1007-14
pubmed: 7726398
Circ Res. 1972 Jul;31(1):83-94
pubmed: 5038740
Circulation. 2013 Oct 15;128(16):1810-52
pubmed: 23741057
Crit Care Med. 2004 Apr;32(4):911-5
pubmed: 15071376
JAMA. 2005 Oct 5;294(13):1625-33
pubmed: 16204662
Crit Care Med. 2013 Dec;41(12):e401-10
pubmed: 23963130
Curr Opin Cardiol. 2003 May;18(3):215-22
pubmed: 12826823
Circ Res. 1958 Sep;6(5):656-69
pubmed: 13573596
Physiol Rev. 1990 Apr;70(2):247-77
pubmed: 2181496
Circ Res. 1969 Dec;25(6):637-49
pubmed: 5364641
Am J Physiol Heart Circ Physiol. 2005 Aug;289(2):H501-12
pubmed: 16014610
Eur Heart J. 2016 Jul 14;37(27):2129-2200
pubmed: 27206819
Circulation. 1986 Sep;74(3):455-62
pubmed: 3742748
Acta Physiol (Oxf). 2011 Dec;203(4):409-18
pubmed: 21658179
Anaesthesia. 2013 May;68(5):512-22
pubmed: 23414556
Acta Physiol (Oxf). 2010 May;199(1):43-52
pubmed: 20102340
Am J Physiol Heart Circ Physiol. 2001 Aug;281(2):H755-63
pubmed: 11454580
Circulation. 1974 Dec;50(6):1179-89
pubmed: 4430113
Crit Care Med. 2003 Dec;31(12):2734-41
pubmed: 14668609
Acta Physiol (Oxf). 2015 Mar;213(3):653-63
pubmed: 25515791
Anesthesiology. 2000 Jan;92(1):84-93
pubmed: 10638903
Circulation. 1971 Jul;44(1):47-58
pubmed: 5561416
Anesthesiology. 1999 Jul;91(1):58-70
pubmed: 10422929
J Am Coll Cardiol. 2004 Jul 21;44(2):340-8
pubmed: 15261929
Am J Physiol. 1979 Mar;236(3):H498-505
pubmed: 426086
Lancet. 2005 Aug 6-12;366(9484):472-7
pubmed: 16084255
Eur J Heart Fail. 2003 Aug;5(4):443-51
pubmed: 12921805
JAMA. 2003 Nov 26;290(20):2713-20
pubmed: 14645314
Am J Cardiol. 1993 May 1;71(12):1111-4
pubmed: 8475880
J Appl Physiol. 1972 Apr;32(4):516-22
pubmed: 5026501
Am Heart J. 1998 Aug;136(2):281-8
pubmed: 9704691
Resuscitation. 2012 Dec;83(12):1503-10
pubmed: 22634434
Physiol Rep. 2013 Nov;1(6):e00159
pubmed: 24400160
Cathet Cardiovasc Diagn. 1988;15(3):192-202
pubmed: 3197110
Cardiovasc Res. 1967 Oct;1(4):313-26
pubmed: 6066335
Circulation. 1993 Jun;87(6 Suppl):VI5-16
pubmed: 8500240
Circulation. 1992 Aug;86(2):563-71
pubmed: 1638722
Anesth Analg. 2011 Nov;113(5):994-1002
pubmed: 21918165
Circulation. 1984 Nov;70(5):812-23
pubmed: 6386218
Circulation. 1986 Mar;73(3):586-95
pubmed: 2868811
Anesthesiology. 1991 May;74(5):815-9
pubmed: 1673591
JAMA. 1996 Sep 18;276(11):889-97
pubmed: 8782638
Circulation. 2005 Dec 13;112(24):3738-44
pubmed: 16330684
Lancet. 1997 Feb 8;349(9049):375-80
pubmed: 9033462
Anesthesiology. 2006 May;104(5):1070-80
pubmed: 16645461
Circulation. 1994 May;89(5):2045-53
pubmed: 8181128
Circ Res. 1996 Oct;79(4):840-8
pubmed: 8831509
JAMA. 2005 Oct 5;294(13):1664-70
pubmed: 16204666
Circ Res. 1971 Feb;28(2):119-35
pubmed: 4994209
Eur J Heart Fail. 2002 Jun;4(3):227-34
pubmed: 12034145