Functional Characterization of Entamoeba histolytica Argonaute Proteins Reveals a Repetitive DR-Rich Motif Region That Controls Nuclear Localization.

Argonaute Proteins / genetics Entamoeba histolytica / genetics Gene Expression Regulation Gene Silencing Protozoan Proteins / genetics RNA Interference RNA, Small Untranslated / metabolism RNA-Induced Silencing Complex / genetics Repetitive Sequences, Nucleic Acid Stress, Physiological
Argonaute proteins Entamoeba RNA interference gene expression transcriptional regulation

Journal

mSphere
ISSN: 2379-5042
Titre abrégé: mSphere
Pays: United States
ID NLM: 101674533

Informations de publication

Date de publication:
16 10 2019
Historique:
entrez: 18 10 2019
pubmed: 18 10 2019
medline: 21 5 2020
Statut: epublish

Résumé

The RNA interference (RNAi) pathway regulates gene expression in many eukaryotic organisms. Argonaute (Ago) proteins, together with bound small RNAs (sRNAs), are key effectors that mediate gene silencing function. However, there is limited knowledge of Ago proteins and their functions in nonmodel systems. In the protozoan parasite

Identifiants

DOI: 10.1128/mSphere.00580-19 PMID: 31619501 PMC: PMC6796981
pubmed: 31619501
pii: 4/5/e00580-19
doi: 10.1128/mSphere.00580-19
pmc: PMC6796981
pii:
doi:

Substances chimiques

Argonaute Proteins 0
Protozoan Proteins 0
RNA, Small Untranslated 0
RNA-Induced Silencing Complex 0

Types de publication

Journal Article Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : NIAID NIH HHS
ID : R01 AI121084
Pays : United States

Informations de copyright

Copyright © 2019 Zhang et al.

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Auteurs

Hanbang Zhang (H)

Division of Infectious Diseases, Department of Internal Medicine, Stanford University School of Medicine, Stanford, California, USA.

Vy Tran (V)

Division of Infectious Diseases, Department of Internal Medicine, Stanford University School of Medicine, Stanford, California, USA.

Dipak Manna (D)

Division of Infectious Diseases, Department of Internal Medicine, Stanford University School of Medicine, Stanford, California, USA.

Gretchen Ehrenkaufer (G)

Division of Infectious Diseases, Department of Internal Medicine, Stanford University School of Medicine, Stanford, California, USA.

Upinder Singh (U)

Division of Infectious Diseases, Department of Internal Medicine, Stanford University School of Medicine, Stanford, California, USA usingh@stanford.edu.
Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, California, USA.

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Nucléoprotéines › Protéines de liaison à l'ARN › Ribonucléoprotéines › Complexe réprimant l'expression de l'ARN › Protéines Argonaute › Functional Characterization of Entamoeba...
questionsmedicales.fr › Eucaryotes › Amoebozoa › Lobosea › Amoebida › Tubulina › Entamoeba › Entamoeba histolytica › Functional Characterization of Entamoeba...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Functional Characterization of Entamoeba...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Épigenèse génétique › Extinction de l'expression des gènes › Functional Characterization of Entamoeba...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de protozoaire › Functional Characterization of Entamoeba...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Épigenèse génétique › Extinction de l'expression des gènes › Interférence par ARN › Functional Characterization of Entamoeba...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ARN › ARN non traduit › Petit ARN non traduit › Functional Characterization of Entamoeba...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Nucléoprotéines › Protéines de liaison à l'ARN › Ribonucléoprotéines › Complexe réprimant l'expression de l'ARN › Functional Characterization of Entamoeba...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Séquences répétées d'acides nucléiques › Functional Characterization of Entamoeba...
questionsmedicales.fr › Phénomènes physiologiques › Stress physiologique › Functional Characterization of Entamoeba...