Catalase Involved in Oxidative Cyclization of the Tetracyclic Ergoline of Fungal Ergot Alkaloids.


Journal

Journal of the American Chemical Society
ISSN: 1520-5126
Titre abrégé: J Am Chem Soc
Pays: United States
ID NLM: 7503056

Informations de publication

Date de publication:
06 11 2019
Historique:
pubmed: 18 10 2019
medline: 28 10 2020
entrez: 18 10 2019
Statut: ppublish

Résumé

A dedicated enzyme for the formation of the central C ring in the tetracyclic ergoline of clinically important ergot alkaloids has never been found. Herein, we report a dual role catalase (EasC), unexpectedly using O

Identifiants

pubmed: 31621316
doi: 10.1021/jacs.9b10217
pmc: PMC7592905
mid: NIHMS1637479
doi:

Substances chimiques

Ergolines 0
Free Radicals 0
Fungal Proteins 0
Catalase EC 1.11.1.6

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

17517-17521

Subventions

Organisme : NIGMS NIH HHS
ID : R01 GM124480
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM008496
Pays : United States

Commentaires et corrections

Type : ErratumIn

Références

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Auteurs

Yongpeng Yao (Y)

State Key Laboratory of Microbial Resources , Institute of Microbiology, Chinese Academy of Sciences , Beijing 100101 , P. R. China.

Chunyan An (C)

State Key Laboratory of Microbial Resources , Institute of Microbiology, Chinese Academy of Sciences , Beijing 100101 , P. R. China.

Declan Evans (D)

Department of Chemistry and Biochemistry , University of California , Los Angeles California 90095 , United States.

Weiwei Liu (W)

State Key Laboratory of Microbial Resources , Institute of Microbiology, Chinese Academy of Sciences , Beijing 100101 , P. R. China.

Wei Wang (W)

State Key Laboratory of Microbial Resources , Institute of Microbiology, Chinese Academy of Sciences , Beijing 100101 , P. R. China.
University of Chinese Academy of Sciences , Beijing 100049 , P. R. China.

Guangzheng Wei (G)

State Key Laboratory of Microbial Resources , Institute of Microbiology, Chinese Academy of Sciences , Beijing 100101 , P. R. China.
University of Chinese Academy of Sciences , Beijing 100049 , P. R. China.

Ning Ding (N)

School of Food Science and Technology , Jiangnan University , Wuxi , Jiangsu 214122 , P. R. China.

K N Houk (KN)

Department of Chemistry and Biochemistry , University of California , Los Angeles California 90095 , United States.

Shu-Shan Gao (SS)

State Key Laboratory of Microbial Resources , Institute of Microbiology, Chinese Academy of Sciences , Beijing 100101 , P. R. China.

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Classifications MeSH