Human Y Chromosome Exerts Pleiotropic Effects on Susceptibility to Atherosclerosis.

Chromosomes, Human, Y Coronary Artery Disease / genetics Gene Expression Genetic Pleiotropy Genetic Predisposition to Disease Haplotypes High-Throughput Nucleotide Sequencing Humans Macrophages / metabolism Male Minor Histocompatibility Antigens / genetics Nuclear Proteins / genetics Phylogeny Risk Factors THP-1 Cells
coronary artery disease epigenomics gene expression humans risk factors

Journal

Arteriosclerosis, thrombosis, and vascular biology
ISSN: 1524-4636
Titre abrégé: Arterioscler Thromb Vasc Biol
Pays: United States
ID NLM: 9505803

Informations de publication

Date de publication:
11 2019
Historique:
entrez: 24 10 2019
pubmed: 24 10 2019
medline: 9 4 2020
Statut: ppublish

Résumé

The male-specific region of the Y chromosome (MSY) remains one of the most unexplored regions of the genome. We sought to examine how the genetic variants of the MSY influence male susceptibility to coronary artery disease (CAD) and atherosclerosis. Approach and Results: Analysis of 129 133 men from UK Biobank revealed that only one of 7 common MSY haplogroups (haplogroup I1) was associated with CAD-carriers of haplogroup I1 had ≈11% increase in risk of CAD when compared with all other haplogroups combined (odds ratio, 1.11; 95% CI, 1.04-1.18; Haplogroup I1 is enriched for regulatory chromatin variants in numerous cells of relevance to CAD and increases cardiovascular risk through proatherosclerotic reprogramming of the transcriptome, partly through

Identifiants

DOI: 10.1161/ATVBAHA.119.312405 PMID: 31644355 PMC: PMC6818981
pubmed: 31644355
doi: 10.1161/ATVBAHA.119.312405
pmc: PMC6818981
doi:

Substances chimiques

Minor Histocompatibility Antigens 0
Nuclear Proteins 0
UTY protein, human 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

2386-2401

Subventions

Organisme : NHLBI NIH HHS
ID : R01 HL125863
Pays : United States
Organisme : British Heart Foundation
ID : PG/12/9/29376
Pays : United Kingdom
Organisme : British Heart Foundation
ID : PG/16/49/32176
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 087576
Pays : United Kingdom
Organisme : British Heart Foundation
ID : CH/13/2/30154
Pays : United Kingdom
Organisme : British Heart Foundation
ID : PG/12/81/29897
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_QA137853
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_PC_17228
Pays : United Kingdom
Organisme : British Heart Foundation
ID : RE/13/5/30177
Pays : United Kingdom

Commentaires et corrections

Type : CommentIn

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Auteurs

James M Eales (JM)

From the Division of Cardiovascular Sciences, Faculty of Biology, Medicine and Health, University of Manchester, United Kingdom (J.M.E., A.A.M., X.X., B.K., M.T.).

Akhlaq A Maan (AA)

From the Division of Cardiovascular Sciences, Faculty of Biology, Medicine and Health, University of Manchester, United Kingdom (J.M.E., A.A.M., X.X., B.K., M.T.).

Xiaoguang Xu (X)

From the Division of Cardiovascular Sciences, Faculty of Biology, Medicine and Health, University of Manchester, United Kingdom (J.M.E., A.A.M., X.X., B.K., M.T.).

Tom Michoel (T)

The Roslin Institute, The University of Edinburgh, United Kingdom (T.M.).
Computational Biology Unit and Department of Informatics, University of Bergen, Norway (T.M.).

Pille Hallast (P)

Institute of Biomedicine and Translational Medicine, University of Tartu, Estonia (P.H.).

Chiara Batini (C)

Department of Health Sciences (C.B., J.T.), University of Leicester, United Kingdom.

Daniel Zadik (D)

Department of Genetics and Genome Biology (D.Z., M.A.J.), University of Leicester, United Kingdom.

Priscilla R Prestes (PR)

School of Health and Life Sciences, Federation University Australia, Ballarat, Victoria (P.R.P., E.M., F.J.C.).

Elsa Molina (E)

School of Health and Life Sciences, Federation University Australia, Ballarat, Victoria (P.R.P., E.M., F.J.C.).

Matthew Denniff (M)

Department of Cardiovascular Sciences (M.D., N.J.S., F.J.C.), University of Leicester, United Kingdom.

Juliane Schroeder (J)

Centre for Immunobiology, Institute of Infection, Immunity and Inflammation (J.S., P.M.), College of Medical, Veterinary and Life Sciences, University of Glasgow, United Kingdom.
Institute of Cardiovascular and Medical Sciences (J.S., P.M., T.J.G.), College of Medical, Veterinary and Life Sciences, University of Glasgow, United Kingdom.

Johan L M Bjorkegren (JLM)

Department of Genetics and Genomic Sciences, Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, NY (J.L.M.B.).

John Thompson (J)

Department of Health Sciences (C.B., J.T.), University of Leicester, United Kingdom.

Pasquale Maffia (P)

Centre for Immunobiology, Institute of Infection, Immunity and Inflammation (J.S., P.M.), College of Medical, Veterinary and Life Sciences, University of Glasgow, United Kingdom.
Institute of Cardiovascular and Medical Sciences (J.S., P.M., T.J.G.), College of Medical, Veterinary and Life Sciences, University of Glasgow, United Kingdom.
Department of Pharmacy, University of Naples Federico II, Italy (P.M.).

Tomasz J Guzik (TJ)

Institute of Cardiovascular and Medical Sciences (J.S., P.M., T.J.G.), College of Medical, Veterinary and Life Sciences, University of Glasgow, United Kingdom.
Jagiellonian University College of Medicine, Kraków, Poland (T.J.G.).

Bernard Keavney (B)

From the Division of Cardiovascular Sciences, Faculty of Biology, Medicine and Health, University of Manchester, United Kingdom (J.M.E., A.A.M., X.X., B.K., M.T.).
Division of Medicine, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre, United Kingdom (B.K., M.T.).

Mark A Jobling (MA)

Department of Genetics and Genome Biology (D.Z., M.A.J.), University of Leicester, United Kingdom.

Nilesh J Samani (NJ)

Department of Cardiovascular Sciences (M.D., N.J.S., F.J.C.), University of Leicester, United Kingdom.
NIHR Leicester Biomedical Research Centre, United Kingdom (N.J.S.).

Fadi J Charchar (FJ)

Department of Cardiovascular Sciences (M.D., N.J.S., F.J.C.), University of Leicester, United Kingdom.
School of Health and Life Sciences, Federation University Australia, Ballarat, Victoria (P.R.P., E.M., F.J.C.).
Department of Physiology, University of Melbourne, Parkville, Victoria, Australia (F.J.C.).

Maciej Tomaszewski (M)

From the Division of Cardiovascular Sciences, Faculty of Biology, Medicine and Health, University of Manchester, United Kingdom (J.M.E., A.A.M., X.X., B.K., M.T.).
Division of Medicine, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre, United Kingdom (B.K., M.T.).

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Classifications MeSH

questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Chromosomes › Chromosomes sexuels › Chromosome Y › Chromosomes Y humains › Human Y Chromosome Exerts Pleiotropic Effects...
questionsmedicales.fr › Maladies cardiovasculaires › Maladies vasculaires › Ischémie myocardique › Maladie coronarienne › Maladie des artères coronaires › Human Y Chromosome Exerts Pleiotropic Effects...
questionsmedicales.fr › Phénomènes génétiques › Expression des gènes › Human Y Chromosome Exerts Pleiotropic Effects...
questionsmedicales.fr › Phénomènes génétiques › Phénotype › Pléiotropie › Human Y Chromosome Exerts Pleiotropic Effects...
questionsmedicales.fr › Phénomènes génétiques › Génotype › Prédisposition génétique à une maladie › Human Y Chromosome Exerts Pleiotropic Effects...
questionsmedicales.fr › Phénomènes génétiques › Génotype › Haplotypes › Human Y Chromosome Exerts Pleiotropic Effects...
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Analyse de séquence › Séquençage nucléotidique à haut débit › Human Y Chromosome Exerts Pleiotropic Effects...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Human Y Chromosome Exerts Pleiotropic Effects...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Phagocytes › Macrophages › Human Y Chromosome Exerts Pleiotropic Effects...
questionsmedicales.fr › Facteurs biologiques › Antigènes › Isoantigènes › Antigènes d'histocompatibilité › Antigènes mineurs d'histocompatibilité › Human Y Chromosome Exerts Pleiotropic Effects...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines nucléaires › Human Y Chromosome Exerts Pleiotropic Effects...
questionsmedicales.fr › Sciences de l'information › Phylogenèse › Human Y Chromosome Exerts Pleiotropic Effects...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Probabilité › Risque › Facteurs de risque › Human Y Chromosome Exerts Pleiotropic Effects...
questionsmedicales.fr › Cellules › Cellules cultivées › Cellules cancéreuses en culture › Lignée cellulaire tumorale › Cellules THP-1 › Human Y Chromosome Exerts Pleiotropic Effects...