Identifying Phlorofucofuroeckol-A as a Dual Inhibitor of Amyloid-β
Amyloid beta-Peptides
/ antagonists & inhibitors
Benzofurans
/ chemistry
Dioxins
/ chemistry
Glycation End Products, Advanced
/ antagonists & inhibitors
Lipid Peroxidation
/ drug effects
Molecular Docking Simulation
Molecular Structure
Phaeophyceae
/ chemistry
Phloroglucinol
/ chemistry
Protein Aggregation, Pathological
phlorotannin, amyloid-β aggregation, insulin glycation, dynamic simulation
Journal
Marine drugs
ISSN: 1660-3397
Titre abrégé: Mar Drugs
Pays: Switzerland
ID NLM: 101213729
Informations de publication
Date de publication:
23 Oct 2019
23 Oct 2019
Historique:
received:
04
10
2019
revised:
19
10
2019
accepted:
20
10
2019
entrez:
27
10
2019
pubmed:
28
10
2019
medline:
16
4
2020
Statut:
epublish
Résumé
Both amyloid-β (Aβ) and insulin are amyloidogenic peptides, and they play a critical role in Alzheimer's disease (AD) and type-2 diabetes (T2D). Misfolded or aggregated Aβ and glycated insulin are commonly found in AD and T2D patients, respectively, and exhibit neurotoxicity and oxidative stress. The present study examined the anti-Aβ
Identifiants
pubmed: 31652867
pii: md17110600
doi: 10.3390/md17110600
pmc: PMC6891666
pii:
doi:
Substances chimiques
Amyloid beta-Peptides
0
Benzofurans
0
Dioxins
0
Glycation End Products, Advanced
0
dieckol
0
dioxinodehydroeckol
0
phlorofucofuroeckol A
128129-56-6
eckol
88798-74-7
Phloroglucinol
DHD7FFG6YS
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
Références
ACS Chem Neurosci. 2017 Jul 19;8(7):1435-1437
pubmed: 28586203
Curr Protein Pept Sci. 2010 Feb;11(1):54-67
pubmed: 20201807
J Biol Chem. 1986 Aug 5;261(22):10282-9
pubmed: 3015924
Biochim Biophys Acta. 2000 Sep 1;1523(1):128-34
pubmed: 11099867
Peptides. 1996;17(8):1323-30
pubmed: 8971927
Bioorg Med Chem. 2008 Sep 1;16(17):7921-6
pubmed: 18693022
Clin Sci Mol Med. 1974 Sep;47(3):215-22
pubmed: 4425439
Prog Mol Biol Transl Sci. 2018;156:413-434
pubmed: 29747822
Invest Ophthalmol Vis Sci. 2010 Oct;51(10):4867-74
pubmed: 20876889
Mar Drugs. 2018 Dec 22;17(1):
pubmed: 30583515
Biochem J. 1966 Jun;99(3):667-76
pubmed: 5964963
Chem Soc Rev. 2019 Jul 15;48(14):3946-3996
pubmed: 31192324
Food Chem Toxicol. 2011 Sep;49(9):2252-9
pubmed: 21693162
Proteins. 2004 May 15;55(3):568-81
pubmed: 15103621
J Herb Pharmacother. 2002;2(2):47-55
pubmed: 15277096
Cells. 2018 Mar 23;7(4):
pubmed: 29570659
Nanomaterials (Basel). 2016 Dec 06;6(12):
pubmed: 28335363
J Med Chem. 2004 Aug 12;47(17):4231-8
pubmed: 15293994
Cell Mol Neurobiol. 2016 May;36(4):483-95
pubmed: 26175217
Alzheimers Dement. 2014 Feb;10(1 Suppl):S26-32
pubmed: 24529521
Arch Pharm Res. 2017 Apr;40(4):480-491
pubmed: 28251489
J Agric Food Chem. 2013 Sep 11;61(36):8541-7
pubmed: 23957842
Int J Cell Biol. 2013;2013:638083
pubmed: 24348562
Diabetes Care. 2003 Jan;26 Suppl 1:S21-4
pubmed: 12502615
J Mol Graph. 1996 Feb;14(1):33-8, 27-8
pubmed: 8744570
Chem Rev. 2019 Jun 26;119(12):6956-6993
pubmed: 30973229
Mar Drugs. 2019 Feb 10;17(2):
pubmed: 30744179
J Agric Food Chem. 2009 May 13;57(9):3483-9
pubmed: 19338274
J Biol Chem. 2016 Feb 12;291(7):3174-83
pubmed: 26719327
Biophys J. 2006 Sep 1;91(5):1638-47
pubmed: 16766615
Antioxidants (Basel). 2019 Jul 24;8(8):
pubmed: 31344959
Arch Pharm Res. 2012 Nov;35(11):1989-98
pubmed: 23212641
Nat Med. 2008 Aug;14(8):837-42
pubmed: 18568035
Food Chem. 2012 Jun 1;132(3):1133-1142
pubmed: 29243592
Sci Rep. 2019 May 9;9(1):7161
pubmed: 31073226
J Neurosci. 1993 Apr;13(4):1676-87
pubmed: 8463843
EBioMedicine. 2017 Nov;25:143-153
pubmed: 29033370
ACS Chem Neurosci. 2012 Nov 21;3(11):952-62
pubmed: 23173074
Biophys J. 2012 Aug 8;103(3):576-586
pubmed: 22947874
Acc Chem Res. 2014 Feb 18;47(2):603-11
pubmed: 24368046
Bioorg Med Chem Lett. 2010 Jun 1;20(11):3211-5
pubmed: 20462757
Sci Rep. 2017 Nov 8;7(1):15086
pubmed: 29118444
J Neurochem. 1995 Jan;64(1):253-65
pubmed: 7798921
Sci Rep. 2016 Sep 09;6:33172
pubmed: 27609215
Curr Pharm Des. 2008;14(10):946-52
pubmed: 18473844
Chem Rev. 2015 May 13;115(9):3518-63
pubmed: 25789869
ACS Chem Neurosci. 2018 Jun 20;9(6):1349-1356
pubmed: 29608860
Mar Drugs. 2015 Mar 30;13(4):1785-97
pubmed: 25830682
Neurochem Res. 1994 Mar;19(3):283-8
pubmed: 8177367
Kidney Int Suppl. 2007 Aug;(106):S17-26
pubmed: 17653206
Neurobiol Aging. 2009 Mar;30(3):377-87
pubmed: 17692997
Bioorg Chem. 2019 Nov;92:103293
pubmed: 31557622
Biomaterials. 2015 Aug;61:52-60
pubmed: 25996411
J Chem Theory Comput. 2019 Feb 12;15(2):1440-1452
pubmed: 30633867
J Mol Recognit. 1996 Jan-Feb;9(1):1-5
pubmed: 8723313
Mar Drugs. 2019 Jun 24;17(6):
pubmed: 31238535
J Neurosci. 2008 Dec 31;28(53):14537-45
pubmed: 19118188
Food Chem Toxicol. 2013 Mar;53:294-8
pubmed: 23261675
Biochim Biophys Acta. 2016 Jan;1862(1):93-104
pubmed: 26519138