Human leukocyte antigens class II in CIDP spectrum neuropathies.
CIDP
Chronic inflammatory demyelinating polyradiculoneuropathy
DR3
DR3/DQ2
HLA
Journal
Journal of the neurological sciences
ISSN: 1878-5883
Titre abrégé: J Neurol Sci
Pays: Netherlands
ID NLM: 0375403
Informations de publication
Date de publication:
15 Dec 2019
15 Dec 2019
Historique:
received:
25
06
2019
revised:
11
10
2019
accepted:
14
10
2019
pubmed:
2
11
2019
medline:
17
9
2020
entrez:
1
11
2019
Statut:
ppublish
Résumé
CIDP spectrum encompasses several clinical variants and the reasons of the heterogeneous clinical expression and the variable response to therapy are scarcely known. HLA associations are common in dysimmune conditions. In CIDP, few studies reported no associations or HLA-DR13/DQ6 association in some populations but, to date, a clear confirmed association is lacking. We analyzed expression of HLA-DR and DQ haplotypes in 24 CIDP patients and 216 healthy subject. HLA-DR3 and DR3/DQ2 were significantly more frequent in CIDP patients than in the control group. The DR3 and DR3/DQ2 positive patients present with more frequent relapsing course, worse response to IVIg, higher inflammatory neuropathy sensory sumscore (ISS) and Rotterdam Inflammatory Neuropathy Cause and Treatment Scale (INCAT) than negative patients.
Identifiants
pubmed: 31670164
pii: S0022-510X(19)30465-4
doi: 10.1016/j.jns.2019.116533
pii:
doi:
Substances chimiques
HLA-DQ Antigens
0
HLA-DR Antigens
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
116533Informations de copyright
Copyright © 2019 Elsevier B.V. All rights reserved.