Biosynthesis and regulation mechanisms of the Pasteurella multocida capsule.

Bacterial Capsules / metabolism Bacterial Vaccines / chemistry Pasteurella multocida / genetics Polysaccharides / biosynthesis Serogroup Virulence Factors / metabolism
Biosynthesis Capsule Expression regulation Glycosaminoglycan Pasteurella multocida

Journal

Research in veterinary science
ISSN: 1532-2661
Titre abrégé: Res Vet Sci
Pays: England
ID NLM: 0401300

Informations de publication

Date de publication:
Dec 2019
Historique:
received: 11 09 2018
revised: 05 09 2019
accepted: 21 10 2019
pubmed: 5 11 2019
medline: 23 2 2020
entrez: 4 11 2019
Statut: ppublish

Résumé

Pasteurella multocida possesses a polysaccharide capsule composed of a viscous surface layer that acts as a critical structural component and virulence factor. Capsular polysaccharides are structurally similar to vertebrate glycosaminoglycans, providing an immunological mechanism for bacterial molecular mimicry, resistance to phagocytosis, and immune evasion during the infection process. In recent years, a series of important research advances have been made in understanding the biosynthesis and regulatory aspects of the P. multocida capsule. This review systematically examines the serogroups, polysaccharide composition and structures, biosynthetic loci and functions, biosynthesis pathways, and expression regulation mechanisms of the P. multocida capsule, supplying a theoretical basis for the molecular pathogenesis of the P. multocida capsule and the future development of capsular polysaccharide vaccines.

Identifiants

DOI: 10.1016/j.rvsc.2019.10.011 PMID: 31678457
pubmed: 31678457
pii: S0034-5288(18)35303-7
doi: 10.1016/j.rvsc.2019.10.011
pii:
doi:

Substances chimiques

Bacterial Vaccines 0
Polysaccharides 0
Virulence Factors 0

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

82-90

Informations de copyright

Copyright © 2019 Elsevier Ltd. All rights reserved.

Auteurs

Lijun Guan (L)

Laboratory of Veterinary Biologics Engineering, College of Animal Science and Technology, Henan University of Science and Technology, Luoyang 471023, China; Key-Disciplines Lab of Safety of Environment and Animal Product, College of Animal Science and Technology, Henan University of Science and Technology, Luoyang 471023, China.

Yun Xue (Y)

Laboratory of Veterinary Biologics Engineering, College of Animal Science and Technology, Henan University of Science and Technology, Luoyang 471023, China.

Wenwen Ding (W)

Laboratory of Veterinary Biologics Engineering, College of Animal Science and Technology, Henan University of Science and Technology, Luoyang 471023, China; Key-Disciplines Lab of Safety of Environment and Animal Product, College of Animal Science and Technology, Henan University of Science and Technology, Luoyang 471023, China.

Zhanqin Zhao (Z)

Laboratory of Veterinary Biologics Engineering, College of Animal Science and Technology, Henan University of Science and Technology, Luoyang 471023, China; Key-Disciplines Lab of Safety of Environment and Animal Product, College of Animal Science and Technology, Henan University of Science and Technology, Luoyang 471023, China. Electronic address: zhaozhanqin@126.com.

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Classifications MeSH

questionsmedicales.fr › Structures bactériennes › Capsules bactériennes › Biosynthesis and regulation mechanisms of the...
questionsmedicales.fr › Mélanges complexes › Produits biologiques › Vaccins › Vaccins antibactériens › Biosynthesis and regulation mechanisms of the...
questionsmedicales.fr › Bactéries › Proteobacteria › Gammaproteobacteria › Pasteurellaceae › Pasteurella › Pasteurella multocida › Biosynthesis and regulation mechanisms of the...
questionsmedicales.fr › Glucides › Polyosides › Biosynthesis and regulation mechanisms of the...
questionsmedicales.fr › Phénomènes génétiques › Phénotype › Sérogroupe › Biosynthesis and regulation mechanisms of the...
questionsmedicales.fr › Facteurs biologiques › Toxines biologiques › Facteurs de virulence › Biosynthesis and regulation mechanisms of the...