Fear conditioning and extinction in alcohol dependence: Evidence for abnormal amygdala reactivity.
Adult
Aged
Alcoholism
/ physiopathology
Amygdala
/ physiopathology
Anxiety Disorders
/ physiopathology
Brain Mapping
Case-Control Studies
Conditioning, Classical
/ physiology
Extinction, Psychological
/ physiology
Fear
/ physiology
Female
Galvanic Skin Response
Humans
Magnetic Resonance Imaging
Male
Mental Recall
Middle Aged
Prefrontal Cortex
/ physiopathology
addiction
alcohol use disorder
amygdala
anxiety
depressive symptoms
fear conditioning
Journal
Addiction biology
ISSN: 1369-1600
Titre abrégé: Addict Biol
Pays: United States
ID NLM: 9604935
Informations de publication
Date de publication:
01 2021
01 2021
Historique:
received:
14
05
2019
revised:
28
08
2019
accepted:
08
09
2019
pubmed:
9
11
2019
medline:
10
9
2021
entrez:
9
11
2019
Statut:
ppublish
Résumé
Fear conditioning and extinction (FCE) are vital processes in adaptive emotion regulation and disrupted in anxiety disorders. Despite substantial comorbidity between alcohol dependence (ALC) and anxiety disorders and reports of altered negative emotion processing in ALC, neural correlates of FCE in this clinical population remain unknown. Here, we used a 2-day fear learning paradigm in 43 healthy participants and 43 individuals with ALC at the National Institutes of Health. Main outcomes of this multimodal study included structural and functional brain magnetic resonance imaging, clinical measures, as well as skin conductance responses (SCRs) to confirm differential conditioning. Successful FCE was demonstrated across participants by differential SCRs in the conditioning phase and no difference in SCRs to the conditioned stimuli in the extinction phase. The ALC group showed significantly reduced blood oxygenation level-dependent responses in the right amygdala during conditioning (Cohen's d = .89, P
Identifiants
pubmed: 31702089
doi: 10.1111/adb.12835
pmc: PMC7205585
mid: NIHMS1050030
doi:
Types de publication
Journal Article
Research Support, N.I.H., Intramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e12835Subventions
Organisme : Intramural NIH HHS
ID : Z99 AA999999
Pays : United States
Organisme : Intramural NIH HHS
ID : ZIA AA000242
Pays : United States
Organisme : Intramural NIH HHS
ID : ZIA AA000242-04
Pays : United States
Informations de copyright
© Published 2019. This article is a U.S. Government work and is in the public domain in the USA.
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