Drop Head Syndrome as a Rare Complication in Mixed Connective Tissue Disease.
Antibodies, Antinuclear
/ blood
Creatine Kinase
/ blood
Female
Glucocorticoids
/ therapeutic use
Humans
Middle Aged
Mixed Connective Tissue Disease
/ complications
Muscle Weakness
/ etiology
Myositis
/ drug therapy
Neck Muscles
/ pathology
Prednisolone
/ therapeutic use
Raynaud Disease
/ complications
drop head syndrome
mixed connective tissue disease
myositis
neck extensor muscles
Journal
Internal medicine (Tokyo, Japan)
ISSN: 1349-7235
Titre abrégé: Intern Med
Pays: Japan
ID NLM: 9204241
Informations de publication
Date de publication:
01 Mar 2020
01 Mar 2020
Historique:
pubmed:
19
11
2019
medline:
15
9
2020
entrez:
19
11
2019
Statut:
ppublish
Résumé
A 54-year-old woman developed drop head syndrome (DHS), Raynaud's phenomenon and creatine kinase (CK) elevation. She did not meet the international classification criteria of dermatomyositis/polymyositis, as we observed no muscle weakness, grasping pain or electromyography abnormality in her limbs, and anti-aminoacyl tRNA synthetase (ARS) antibody was negative. Cervical magnetic resonance imaging and a muscle biopsy of the trapezius muscle revealed myositis findings as the only clinical observations in muscle. These findings, along with her anti-U1-ribonucleoprotein (RNP) antibody positivity and leukopenia, resulted in a diagnosis of mixed connective tissue disease (MCTD). Prednisolone treatment significantly improved her myositis. To our knowledge, this is the first report of DHS as the only muscle complication of MCTD.
Identifiants
pubmed: 31735790
doi: 10.2169/internalmedicine.3626-19
pmc: PMC7086316
doi:
Substances chimiques
Antibodies, Antinuclear
0
Glucocorticoids
0
Prednisolone
9PHQ9Y1OLM
Creatine Kinase
EC 2.7.3.2
Types de publication
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
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