Genetic predisposition to mosaic Y chromosome loss in blood.

Adult Aged Chromosome Deletion Chromosomes, Human, Y / genetics Computational Biology Databases, Genetic Female Genetic Markers / genetics Genetic Predisposition to Disease / genetics Genomic Instability / genetics Humans Leukocytes / pathology Male Middle Aged Mosaicism Neoplasms / genetics United Kingdom

Journal

Nature
ISSN: 1476-4687
Titre abrégé: Nature
Pays: England
ID NLM: 0410462

Informations de publication

Date de publication:
11 2019
Historique:
received: 09 01 2019
accepted: 04 10 2019
pubmed: 22 11 2019
medline: 14 4 2020
entrez: 22 11 2019
Statut: ppublish

Résumé

Mosaic loss of chromosome Y (LOY) in circulating white blood cells is the most common form of clonal mosaicism

Identifiants

DOI: 10.1038/s41586-019-1765-3 PMID: 31748747 PMC: PMC6887549
pubmed: 31748747
doi: 10.1038/s41586-019-1765-3
pii: 10.1038/s41586-019-1765-3
pmc: PMC6887549
mid: EMS84547
doi:

Substances chimiques

Genetic Markers 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

652-657

Subventions

Organisme : Medical Research Council
ID : MC_UU_00007/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_PC_U127527198
Pays : United Kingdom
Organisme : European Research Council
ID : 679744
Pays : International
Organisme : Cancer Research UK
ID : 12076
Pays : United Kingdom
Organisme : Worldwide Cancer Research
ID : 12-1087
Pays : United Kingdom
Organisme : Medical Research Council
ID : G1000143
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_12015/2
Pays : United Kingdom
Organisme : Cancer Research UK
ID : 14136
Pays : United Kingdom
Organisme : Medical Research Council
ID : G0401527
Pays : United Kingdom
Organisme : NIEHS NIH HHS
ID : DP2 ES030554
Pays : United States
Organisme : Medical Research Council
ID : MC_PC_17228
Pays : United Kingdom
Organisme : Medical Research Council
ID : G0600237
Pays : United Kingdom
Organisme : Medical Research Council
ID : G0600329
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/N003284/1
Pays : United Kingdom
Organisme : NIGMS NIH HHS
ID : R35 GM118172
Pays : United States
Organisme : Medical Research Council
ID : G0500300
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_QA137853
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_12015/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_U127527198
Pays : United Kingdom

Commentaires et corrections

Type : CommentIn

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Auteurs

Deborah J Thompson (DJ)

Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.

Giulio Genovese (G)

Department of Genetics, Harvard Medical School, Boston, MA, USA.
Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.

Jonatan Halvardson (J)

Department of Immunology, Genetics and Pathology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden.

Jacob C Ulirsch (JC)

Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Program in Biological and Biomedical Sciences, Harvard Medical School, Boston, MA, USA.

Daniel J Wright (DJ)

MRC Epidemiology Unit, School of Clinical Medicine, University of Cambridge, Cambridge, UK.
Open Targets Core Genetics, Wellcome Sanger Institute, Hinxton, UK.

Chikashi Terao (C)

Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan.
Clinical Research Center, Shizuoka General Hospital, Shizuoka, Japan.
Department of Applied Genetics, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan.
Laboratory for Statistical and Translational Genetics, RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan.

Olafur B Davidsson (OB)

deCODE Genetics, Amgen, Reykjavík, Iceland.

Felix R Day (FR)

MRC Epidemiology Unit, School of Clinical Medicine, University of Cambridge, Cambridge, UK.
Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.

Patrick Sulem (P)

deCODE Genetics, Amgen, Reykjavík, Iceland.

Yunxuan Jiang (Y)

23andMe, Mountain View, CA, USA.

Marcus Danielsson (M)

Department of Immunology, Genetics and Pathology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden.

Hanna Davies (H)

Department of Immunology, Genetics and Pathology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden.

Joe Dennis (J)

Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.

Malcolm G Dunlop (MG)

Colon Cancer Genetics Group, Medical Research Council Human Genetics Unit and CRUK Cancer Research Centre, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, UK.

Douglas F Easton (DF)

Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.

Victoria A Fisher (VA)

Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.

Florian Zink (F)

deCODE Genetics, Amgen, Reykjavík, Iceland.

Richard S Houlston (RS)

Division of Genetics and Epidemiology, The Institute of Cancer Research, London, UK.

Martin Ingelsson (M)

Geriatrics Research Group, Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden.

Siddhartha Kar (S)

Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK.

Nicola D Kerrison (ND)

MRC Epidemiology Unit, School of Clinical Medicine, University of Cambridge, Cambridge, UK.

Ben Kinnersley (B)

Division of Genetics and Epidemiology, The Institute of Cancer Research, London, UK.

Ragnar P Kristjansson (RP)

deCODE Genetics, Amgen, Reykjavík, Iceland.

Philip J Law (PJ)

Division of Genetics and Epidemiology, The Institute of Cancer Research, London, UK.

Rong Li (R)

Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Chey Loveday (C)

Division of Genetics and Epidemiology, The Institute of Cancer Research, London, UK.

Jonas Mattisson (J)

Department of Immunology, Genetics and Pathology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden.

Steven A McCarroll (SA)

Department of Genetics, Harvard Medical School, Boston, MA, USA.
Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.

Yoshinori Murakami (Y)

Division of Molecular Pathology, Institute of Medical Science, University of Tokyo, Tokyo, Japan.

Anna Murray (A)

Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, UK.

Pawel Olszewski (P)

Faculty of Pharmacy, Medical University of Gdansk, Gdansk, Poland.

Edyta Rychlicka-Buniowska (E)

Department of Immunology, Genetics and Pathology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden.
Faculty of Pharmacy, Medical University of Gdansk, Gdansk, Poland.

Robert A Scott (RA)

MRC Epidemiology Unit, School of Clinical Medicine, University of Cambridge, Cambridge, UK.

Unnur Thorsteinsdottir (U)

deCODE Genetics, Amgen, Reykjavík, Iceland.
Faculty of Medicine, University of Iceland, Reykjavík, Iceland.

Ian Tomlinson (I)

Cancer Genetics and Evolution Laboratory, Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK.

Behrooz Torabi Moghadam (BT)

Department of Immunology, Genetics and Pathology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden.

Clare Turnbull (C)

Division of Genetics and Epidemiology, The Institute of Cancer Research, London, UK.
William Harvey Research Institute, Queen Mary University, London, UK.

Nicholas J Wareham (NJ)

MRC Epidemiology Unit, School of Clinical Medicine, University of Cambridge, Cambridge, UK.

Daniel F Gudbjartsson (DF)

deCODE Genetics, Amgen, Reykjavík, Iceland.
School of Engineering and Natural Sciences, University of Iceland, Reykjavík, Iceland.

Yoichiro Kamatani (Y)

Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan.
Laboratory for Statistical and Translational Genetics, RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan.
Kyoto-McGill International Collaborative School in Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan.

Eva R Hoffmann (ER)

DNRF Center for Chromosome Stability, Department of Cellular and Molecular Medicine, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark.

Steve P Jackson (SP)

Department of Biochemistry, University of Cambridge, Cambridge, UK.
Wellcome Trust and Cancer Research UK Gurdon Institute, University of Cambridge, Cambridge, UK.

Kari Stefansson (K)

deCODE Genetics, Amgen, Reykjavík, Iceland.
Faculty of Medicine, University of Iceland, Reykjavík, Iceland.

Adam Auton (A)

23andMe, Mountain View, CA, USA.

Ken K Ong (KK)

MRC Epidemiology Unit, School of Clinical Medicine, University of Cambridge, Cambridge, UK.

Mitchell J Machiela (MJ)

Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.

Po-Ru Loh (PR)

Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.

Jan P Dumanski (JP)

Department of Immunology, Genetics and Pathology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden.
Faculty of Pharmacy, Medical University of Gdansk, Gdansk, Poland.

Stephen J Chanock (SJ)

Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.

Lars A Forsberg (LA)

Department of Immunology, Genetics and Pathology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden.
Beijer Laboratory of Genome Research, Uppsala University, Uppsala, Sweden.

John R B Perry (JRB)

MRC Epidemiology Unit, School of Clinical Medicine, University of Cambridge, Cambridge, UK. john.perry@mrc-epid.cam.ac.uk.
Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands. john.perry@mrc-epid.cam.ac.uk.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Genetic predisposition to mosaic Y chromosome...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Genetic predisposition to mosaic Y chromosome...
questionsmedicales.fr › Phénomènes génétiques › Ploïdies › Aneuploïdie › Monosomie › Délétion de segment de chromosome › Genetic predisposition to mosaic Y chromosome...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Chromosomes › Chromosomes sexuels › Chromosome Y › Chromosomes Y humains › Genetic predisposition to mosaic Y chromosome...
questionsmedicales.fr › Sciences de l'information › Informatique › Biologie informatique › Genetic predisposition to mosaic Y chromosome...
questionsmedicales.fr › Sciences de l'information › Mémorisation et recherche des informations › Bases de données comme sujet › Bases de données factuelles › Bases de données génétiques › Genetic predisposition to mosaic Y chromosome...
questionsmedicales.fr › Phénomènes génétiques › Phénotype › Marqueurs génétiques › Genetic predisposition to mosaic Y chromosome...
questionsmedicales.fr › Phénomènes génétiques › Génotype › Prédisposition génétique à une maladie › Genetic predisposition to mosaic Y chromosome...
questionsmedicales.fr › Phénomènes génétiques › Instabilité du génome › Genetic predisposition to mosaic Y chromosome...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Genetic predisposition to mosaic Y chromosome...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Genetic predisposition to mosaic Y chromosome...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › Genetic predisposition to mosaic Y chromosome...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Mutation › Aberrations des chromosomes › Mosaïcisme › Genetic predisposition to mosaic Y chromosome...
questionsmedicales.fr › Tumeurs › Genetic predisposition to mosaic Y chromosome...
questionsmedicales.fr › Régions géographiques › Europe › Royaume-Uni › Genetic predisposition to mosaic Y chromosome...