Prefrontal cortical ChAT-VIP interneurons provide local excitation by cholinergic synaptic transmission and control attention.
Acetylcholine
/ pharmacology
Animals
Attention
/ drug effects
Cerebral Cortex
/ cytology
Choline O-Acetyltransferase
/ metabolism
Cholinergic Agents
/ pharmacology
Female
Interneurons
/ drug effects
Male
Mice, 129 Strain
Neurons
/ drug effects
Prefrontal Cortex
/ cytology
Rats
Synaptic Transmission
/ drug effects
Vasoactive Intestinal Peptide
/ metabolism
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
21 11 2019
21 11 2019
Historique:
received:
16
10
2019
accepted:
29
10
2019
entrez:
23
11
2019
pubmed:
23
11
2019
medline:
10
3
2020
Statut:
epublish
Résumé
Neocortical choline acetyltransferase (ChAT)-expressing interneurons are a subclass of vasoactive intestinal peptide (ChAT-VIP) neurons of which circuit and behavioural function are unknown. Here, we show that ChAT-VIP neurons directly excite neighbouring neurons in several layers through fast synaptic transmission of acetylcholine (ACh) in rodent medial prefrontal cortex (mPFC). Both interneurons in layers (L)1-3 as well as pyramidal neurons in L2/3 and L6 receive direct inputs from ChAT-VIP neurons mediated by fast cholinergic transmission. A fraction (10-20%) of postsynaptic neurons that received cholinergic input from ChAT-VIP interneurons also received GABAergic input from these neurons. In contrast to regular VIP interneurons, ChAT-VIP neurons did not disinhibit pyramidal neurons. Finally, we show that activity of these neurons is relevant for behaviour and they control attention behaviour distinctly from basal forebrain ACh inputs. Thus, ChAT-VIP neurons are a local source of cortical ACh that directly excite neurons throughout cortical layers and contribute to attention.
Identifiants
pubmed: 31754098
doi: 10.1038/s41467-019-13244-9
pii: 10.1038/s41467-019-13244-9
pmc: PMC6872593
doi:
Substances chimiques
Cholinergic Agents
0
Vasoactive Intestinal Peptide
37221-79-7
Choline O-Acetyltransferase
EC 2.3.1.6
Acetylcholine
N9YNS0M02X
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
5280Subventions
Organisme : European Research Council
ID : 281443
Pays : International
Commentaires et corrections
Type : ErratumIn
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