Structural core of the executive control network: A high angular resolution diffusion MRI study.
Adolescent
Adult
Aged
Brain Mapping
Cognition
Cohort Studies
Connectome
Diffusion Magnetic Resonance Imaging
Diffusion Tensor Imaging
Executive Function
/ physiology
Female
Frontal Lobe
/ diagnostic imaging
Humans
Male
Middle Aged
Neostriatum
/ diagnostic imaging
Nerve Net
/ diagnostic imaging
Neural Pathways
Neuropsychological Tests
Parietal Lobe
/ diagnostic imaging
White Matter
/ diagnostic imaging
Young Adult
Journal
Human brain mapping
ISSN: 1097-0193
Titre abrégé: Hum Brain Mapp
Pays: United States
ID NLM: 9419065
Informations de publication
Date de publication:
01 04 2020
01 04 2020
Historique:
received:
13
08
2019
revised:
27
10
2019
accepted:
05
11
2019
pubmed:
26
11
2019
medline:
18
9
2021
entrez:
26
11
2019
Statut:
ppublish
Résumé
Executive function (EF) is a set of cognitive capabilities considered essential for successful daily living, and is negatively affected by ageing and neurodegenerative conditions. Underpinning EF performance are functional nodes in the executive control network (ECN), while the structural connectivity underlying this network is not well understood. In this paper, we evaluated the structural white matter tracts that interconnect the ECN and investigated their relationship to the EF performance. Using high-angular resolution diffusion MRI data, we performed tractography analysis of structural connectivity in a cognitively normal cohort (n = 140), specifically targeting the connectivity between ECN nodes. Our data revealed the presence of a strongly-connected "structural core" of the ECN comprising three components: interhemispheric frontal connections, a fronto-parietal subnetwork and fronto-striatal connections between right dorsolateral prefrontal cortex and right caudate. These pathways were strongly correlated with EF performance (p = .003). Post-hoc analysis of subregions within the significant ECN connections showed that these effects were driven by a highly specific subset of interconnected cortical regions. The structural core subnetwork of the functional ECN may be an important feature crucial to a better future understanding of human cognition and behaviour.
Identifiants
pubmed: 31765057
doi: 10.1002/hbm.24870
pmc: PMC7267982
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1226-1236Informations de copyright
© 2019 The Authors. Human Brain Mapping published by Wiley Periodicals, Inc.
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