Differential Sensitivity of Mycobacteria to Isoniazid Is Related to Differences in KatG-Mediated Enzymatic Activation of the Drug.


Journal

Antimicrobial agents and chemotherapy
ISSN: 1098-6596
Titre abrégé: Antimicrob Agents Chemother
Pays: United States
ID NLM: 0315061

Informations de publication

Date de publication:
27 01 2020
Historique:
received: 18 09 2019
accepted: 19 11 2019
pubmed: 27 11 2019
medline: 5 1 2021
entrez: 27 11 2019
Statut: epublish

Résumé

Isoniazid (INH) is a cornerstone of antitubercular therapy.

Identifiants

pubmed: 31767723
pii: AAC.01899-19
doi: 10.1128/AAC.01899-19
pmc: PMC6985715
pii:
doi:

Substances chimiques

Antitubercular Agents 0
Bacterial Proteins 0
Heme-Binding Proteins 0
Catalase EC 1.11.1.6
katG protein, Mycobacterium tuberculosis EC 1.11.1.6
Isoniazid V83O1VOZ8L

Types de publication

Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Commentaires et corrections

Type : CommentIn

Informations de copyright

Copyright © 2020 American Society for Microbiology.

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Auteurs

Tali H Reingewertz (TH)

Koret School of Veterinary Medicine, The Robert H. Smith Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem, Rehovot, Israel.

Tom Meyer (T)

Koret School of Veterinary Medicine, The Robert H. Smith Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem, Rehovot, Israel.

Fiona McIntosh (F)

McGill University Health Center, Montreal, Quebec, Canada.

Jaryd Sullivan (J)

McGill University Health Center, Montreal, Quebec, Canada.

Michal Meir (M)

Koret School of Veterinary Medicine, The Robert H. Smith Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem, Rehovot, Israel.
The Ruth Rappaport Children's Hospital, Rambam Health Care Campus, Haifa, Israel.

Yung-Fu Chang (YF)

Cornell Veterinary College, Cornell University, Ithaca, New York, USA.

Marcel A Behr (MA)

McGill University Health Center, Montreal, Quebec, Canada.

Daniel Barkan (D)

Koret School of Veterinary Medicine, The Robert H. Smith Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem, Rehovot, Israel daniel.barkan@mail.huji.ac.il.

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Classifications MeSH